BMI1

This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. [provided by RefSeq, Sep 2015]

Description

BMI1 proto-oncogene, polycomb ring finger

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nucleoli, Nuclear bodies, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

10 (22321099 - 22331484)

Ensembl ID

ENSG00000168283  (ver. 103.38)

Orthologs

-

UniProt

P35226

neXtProt

NX_P35226

Human splice variants

Protein structure