A00511

antibody from Boster Biological Technology

Targeting: CDK5 PSSALRE

Immunoprecipitation (Data presented on provider website)

Immunohistochemistry (Data presented on provider website)

Antibody Data

Product number

A00511

Provider

Boster Biological Technology

Product name

Anti-Cyclin-dependent-like kinase 5 Cdk5 Antibody

Antibody type

Polyclonal

Description

Polyclonal antibody for CDK5 detection. Host: Rabbit.Size: 100μL. Tested applications: IP. Reactive species: Human. CDK5 information: Molecular Weight: 33304 MW; Subcellular Localization: Isoform 1: Cytoplasm. Cell membrane; Peripheral membrane protein. Perikaryon. Cell projection, lamellipodium . Cell projection, growth cone . Cell junction, synapse, postsynaptic cell membrane, postsynaptic density . In axonal growth cone with extension to the peripheral lamellipodia (By similarity). Under neurotoxic stress and neuronal injury conditions, CDK5R (p35) is cleaved by calpain to generate CDK5R1 (p25) in response to increased intracellular calcium. The elevated level of p25, when in complex with CDK5, leads to its subcellular misallocation as well as its hyperactivation. Colocalizes with CTNND2 in the cell body of neuronal cells, and with CTNNB1 in the cell-cell contacts and plasma membrane of undifferentiated and differentiated neuroblastoma cells. Reversibly attached to the plasma membrane in an inactive form when complexed to dephosphorylated p35 or CDK5R2 (p39), p35 phosphorylation releases this attachment and activates CDK5; Tissue Specificity: Isoform 1 is ubiquitously expressed. Accumulates in cortical neurons (at protein level). Isoform 2 has only been detected in testis, skeletal muscle, colon, bone marrow and ovary.

Reactivity

Human

Host

Rabbit

Vial size

100μL

Concentration

85 mg/mL by Refractometry