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antibody from Invitrogen Antibodies
Targeting: TFRC
CD71, p90, TFR1
Western blot
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- Antibody Data
- Antigen structure
- References [639]
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- Validations
- Western blot [3]
- Immunocytochemistry [1]
- Other assay [7]
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- Product number
- 13-6800 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Transferrin Receptor Monoclonal Antibody (H68.4)
- Antibody type
- Monoclonal
- Antigen
- Recombinant full-length protein
- Description
- H68.4 is specific to residues 3-28 of the human transferrin receptor (TfR) tail.
- Reactivity
- Human, Mouse, Rat, Chicken/Avian, Hamster
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- H68.4
- Vial size
- 100 µg
- Concentration
- 0.5 mg/mL
- Storage
- -20°C
Submitted references Discovery of Small Molecule KCC2 Potentiators Which Attenuate In Vitro Seizure-Like Activity in Cultured Neurons.
Endocytosis in the axon initial segment maintains neuronal polarity.
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167.
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration.
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond.
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.
Correlation Analyses of Clinical Manifestations and Variant Effects in KCNB1-Related Neurodevelopmental Disorder.
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.
Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth.
Evaluation of TFR-1 Expression in Feline Mammary Cancer and In Vitro Antitumor Efficacy Study of Doxorubicin-Loaded H-Ferritin Nanocages.
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides.
The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.
Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity.
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Localization and Kinetics of the Transferrin-Dependent Iron Transport Machinery in the Mouse Placenta.
RBD11, a bioengineered Rab11-binding module for visualizing and analyzing endogenous Rab11.
β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway.
Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood-Brain Barrier in vivo and in vitro.
Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice.
Heme Oxygenase-1 Supports Mitochondrial Energy Production and Electron Transport Chain Activity in Cultured Lung Epithelial Cells.
PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
CD44 regulates epigenetic plasticity by mediating iron endocytosis.
Therapeutic effect of a histone demethylase inhibitor in Parkinson's disease.
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder.
Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD(+) /NADH ratios.
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy.
Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef.
Transferrin Receptor Is a Specific Ferroptosis Marker.
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription.
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism.
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human.
Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits.
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice.
Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells.
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis.
Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed.
Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1.
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism.
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome.
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Downregulation of TfR1 promotes progression of colorectal cancer via the JAK/STAT pathway.
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia.
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor.
The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking.
Serotonin 5-HT(2C) Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.
Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model.
Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.
Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion.
GRASP depletion-mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin.
Disturbed neurotransmitter homeostasis in ether lipid deficiency.
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.
miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma.
ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin.
TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke.
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
A causal role for TRESK loss of function in migraine mechanisms.
Quantitative proteomics reveals reduction of endocytic machinery components in gliomas.
Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA(A) receptors.
Sex-regulated gene dosage effect of PPARα on synaptic plasticity.
Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin-cubilin complex and transferrin receptor 1.
Extracellular small non-coding RNA contaminants in fetal bovine serum and serum-free media.
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
Epithelial Keratins Modulate cMet Expression and Signaling and Promote InlB-Mediated Listeria monocytogenes Infection of HeLa Cells.
Efficient ultrafiltration-based protocol to deplete extracellular vesicles from fetal bovine serum.
New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia.
Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism.
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.
Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity.
Caveolin-1 Promotes Early Neuronal Maturation via Caveolae-Independent Trafficking of N-Cadherin and L1.
Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission.
An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.
Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2.
Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface.
A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4(+) T cell-macrophage immunological synapses.
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.
Inflammation-induced iron transport and metabolism by brain microglia.
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Dietary Iron Fortification Normalizes Fetal Hematology, Hepcidin, and Iron Distribution in a Rat Model of Prenatal Alcohol Exposure.
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.
Tuning of delta-protocadherin adhesion through combinatorial diversity.
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.
Sensitization of TRPV1 receptors by TNF-α orchestrates the development of vincristine-induced pain.
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.
Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.
Pulmonary Iron Homeostasis in Hepcidin Knockout Mice.
Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN).
High-Content Imaging Reveals Expansion of the Endosomal Compartment during Coxiella burnetii Parasitophorous Vacuole Maturation.
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells.
Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
Effects of epigallocatechin‑3‑gallate on iron metabolism in spinal cord motor neurons.
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains.
The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor.
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.
Novel ecto-tagged integrins reveal their trafficking in live cells.
The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria.
Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth.
Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114).
Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles.
The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis.
F-actin reorganization by V-ATPase inhibition in prostate cancer.
Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA(B) Receptor Protein Complex.
Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism.
EBV MicroRNA BART16 Suppresses Type I IFN Signaling.
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia.
Sphingomyelins and ceramides with VLCPUFAs are excluded from low-density raft-like domains in differentiating spermatogenic cells.
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum.
Na(+)/H(+) Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation.
Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis.
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Iron addiction: a novel therapeutic target in ovarian cancer.
Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.
Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy.
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.
Essential and selective role of SNX12 in transport of endocytic and retrograde cargo.
SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
The role of microsporidian polar tube protein 4 (PTP4) in host cell infection.
mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery.
Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
A kainate receptor subunit promotes the recycling of the neuron-specific K(+)-Cl(-) co-transporter KCC2 in hippocampal neurons.
A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.
The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer.
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.
Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi's sarcoma-associated herpesvirus.
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.
Iron, microbiota and colorectal cancer.
Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens.
Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6.
Atg9A trafficking through the recycling endosomes is required for autophagosome formation.
Aberrant Splicing Promotes Proteasomal Degradation of L-type Ca(V)1.2 Calcium Channels by Competitive Binding for Ca(V)β Subunits in Cardiac Hypertrophy.
The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling.
Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABA(A) receptors.
Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.
Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats.
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.
Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation.
Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity.
The potential of deferasirox as a novel therapeutic modality in gastric cancer.
Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice.
Prenatal Alcohol Exposure Alters Fetal Iron Distribution and Elevates Hepatic Hepcidin in a Rat Model of Fetal Alcohol Spectrum Disorders.
Transferrin receptor facilitates TGF-β and BMP signaling activation to control craniofacial morphogenesis.
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice.
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
Proteomic analysis of native cerebellar iFGF14 complexes.
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
A phosphoinositide conversion mechanism for exit from endosomes.
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.
OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.
Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration.
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.
Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane.
Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease.
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.
Lrp4 in astrocytes modulates glutamatergic transmission.
Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.
The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain.
African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes.
Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy.
Ultrastructural relationship of the phagophore with surrounding organelles.
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.
Role for Rab10 in Methamphetamine-Induced Behavior.
Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.
High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Novel Role of TRPML2 in the Regulation of the Innate Immune Response.
Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.
Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation.
Synaptic activity regulates AMPA receptor trafficking through different recycling pathways.
Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation.
LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation.
Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.
Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells.
Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization.
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor.
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
A novel model for brain iron uptake: introducing the concept of regulation.
Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells.
Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.
A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.
Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease.
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.
Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.
α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function.
Microtubule-dependent modulation of adhesion complex composition.
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
The level of HER2 expression is a predictor of antibody-HER2 trafficking behavior in cancer cells.
Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes.
Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.
De novo KCNB1 mutations in epileptic encephalopathy.
CUB domain containing protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells.
Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats.
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.
Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice.
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.
Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear.
Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2.
DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles.
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers.
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
The lipid raft-bound alkaline phosphatase activity increases and the level of transcripts remains unaffected in liver of merosin-deficient LAMA2dy mouse.
Regulation of Rac1 translocation and activation by membrane domains and their boundaries.
Proteomics-Based Identification of Differentially Abundant Proteins from Human Keratinocytes Exposed to Arsenic Trioxide.
A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression.
Phagolysosomal Trafficking Assay.
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.
Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress.
A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display.
Arf4 is required for Mammalian development but dispensable for ciliary assembly.
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.
Impaired renal function and development in Belgrade rats.
Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice.
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
Stable cell surface expression of GPI-anchored proteins, but not intracellular transport, depends on their fatty acid structure.
Iron increases APP translation and amyloid-beta production in the retina.
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.
aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.
Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.
Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses.
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.
Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.
Prion protein accumulation in lipid rafts of mouse aging brain.
Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo.
Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.
Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer.
Prolonged high fat diet reduces dopamine reuptake without altering DAT gene expression.
Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane.
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection.
A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice.
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3.
Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.
A novel actin cytoskeleton-dependent noncaveolar microdomain composed of homo-oligomeric caveolin-2 for activation of insulin signaling.
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.
Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton.
Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes.
A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.
A role for cargo in Arf-dependent adaptor recruitment.
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome.
Apical sorting of lysoGPI-anchored proteins occurs independent of association with detergent-resistant membranes but dependent on their N-glycosylation.
Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps.
Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex.
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism.
Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.
Nerve growth factor-induced endocytosis of TWIK-related acid-sensitive K⁺ 1 channels in adrenal medullary cells and PC12 cells.
The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action.
The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments.
Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources.
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.
Brain angiotensin regulates iron homeostasis in dopaminergic neurons and microglial cells.
Immunocytochemical and biochemical detection of the urokinase-type plasminogen activator receptor (uPAR) in the rat tooth germ and in lipid rafts of PMA-stimulated dental epithelial cells.
Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis.
Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes.
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis.
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.
The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney.
Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes.
Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.
X-ray fluorescence imaging: a new tool for studying manganese neurotoxicity.
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.
Arenavirus infection induces discrete cytosolic structures for RNA replication.
α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors.
Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins.
Nitric oxide induces segregation of decay accelerating factor (DAF or CD55) from the membrane lipid-rafts and its internalization in human endometrial cells.
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
Interaction of influenza A virus matrix protein with RACK1 is required for virus release.
Activation of P2X7R and downstream effects in bleomycin treated lung epithelial cells.
Differential expression of potassium channels in placentas from normal and pathological pregnancies: targeting of the K(ir) 2.1 channel to lipid rafts.
Immunophenotyping invasive breast cancer: paving the road for molecular imaging.
Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams.
Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
Cullin-3 regulates late endosome maturation.
GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
Anti-melanogenic property of geoditin A in murine B16 melanoma cells.
Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.
ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.
Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.
Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues.
Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.
Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells.
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
Relationship between localization on cellular membranes and cytotoxicity of Vibrio vulnificus hemolysin.
MICAL-like1 mediates epidermal growth factor receptor endocytosis.
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2.
Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase.
Mutations in TRPV4 cause an inherited arthropathy of hands and feet.
A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.
Expression and distribution of nucleoside transporter proteins in the human syncytiotrophoblast.
The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB.
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response.
Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.
Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.
Transferrin receptor expression in canine lymphoma.
Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency.
Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target.
COMMD1-mediated ubiquitination regulates CFTR trafficking.
Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Lipid rafts and cytoskeletal proteins in placental microvilli membranes from preeclamptic and IUGR pregnancies.
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.
Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts.
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas.
Transient expression of iron transport proteins in the capillary of the developing rat brain.
Acetaldehyde/alcohol dehydrogenase-2 (EhADH2) and clathrin are involved in internalization of human transferrin by Entamoeba histolytica.
Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release.
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.
Automated analysis of neuronal morphology, synapse number and synaptic recruitment.
Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin.
The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins.
Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin.
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.
Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.
Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions.
Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
T1alpha/podoplanin shows raft-associated distribution in mouse lung alveolar epithelial E10 cells.
Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).
CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens.
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles.
Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal.
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.
Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.
Ebola virus uses clathrin-mediated endocytosis as an entry pathway.
Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.
Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein.
Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity.
Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources.
Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity.
ZF21 protein regulates cell adhesion and motility.
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages.
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells.
Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts.
Cloning and tissue expression of the equine transferrin receptor.
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.
Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.
Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes.
Ethanol alters endosomal recycling of human dopamine transporters.
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain.
Compartmentalization of epidermal growth factor receptor in liver plasma membrane.
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes.
SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.
Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.
Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice.
Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells.
Exosomal sorting of the cytoplasmic domain of bovine leukemia virus TM Env protein.
Raft aggregation with specific receptor recruitment is required for microglial phagocytosis of Abeta42.
Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors.
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
Differential effects of EGFR ligands on endocytic sorting of the receptor.
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
Isolation of rafts from mouse brain tissue by a detergent-free method.
Cell-surface biotinylation to study endocytosis and recycling of occludin.
Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells.
Human RME-8 is involved in membrane trafficking through early endosomes.
Human RME-8 is involved in membrane trafficking through early endosomes.
Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.
Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
Single vesicle analysis of endocytic fission on microtubules in vitro.
Cholesterol substitution increases the structural heterogeneity of caveolae.
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.
Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent.
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells.
New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1.
Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.
Receptor use by the Whitewater Arroyo virus glycoprotein.
TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway.
Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis?
Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma.
Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover.
Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.
The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy.
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic.
Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus.
Dynamics of somatostatin type 2A receptor cargoes in living hippocampal neurons.
Rab11-FIP2 regulates differentiable steps in transcytosis.
Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells.
The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin.
R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
Cytoskeletal involvement in the cellular trafficking of plasmid/PEI derivative complexes.
Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro.
Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells.
The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.
Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains.
Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts.
Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha.
Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway.
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.
Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes.
Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies.
Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway.
The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein.
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking.
Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells.
Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells.
Pael receptor is involved in dopamine metabolism in the nigrostriatal system.
Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex.
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes.
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.
Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells.
Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.
GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi.
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
The HIV lipidome: a raft with an unusual composition.
Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake.
Functional characterization of HIV-1 Nef mutants in the context of viral infection.
CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
Two mink parvoviruses use different cellular receptors for entry into CRFK cells.
Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner.
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.
Rat brain iron concentration is lower following perinatal copper deficiency.
Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells.
Microanatomy of axon/glial signaling during Wallerian degeneration.
Occult celiac disease prevents penetrance of hemochromatosis.
Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus.
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study.
Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects.
Enhanced expression of transferrin receptor confers UV-resistance in human and monkey cells.
Enhanced expression of transferrin receptor confers UV-resistance in human and monkey cells.
Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment.
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.
The DnaJ-domain protein RME-8 functions in endosomal trafficking.
Endocytosis resumes during late mitosis and is required for cytokinesis.
Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles.
Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network.
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression.
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.
Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity.
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
Adaptive changes of duodenal iron transport proteins in celiac disease.
The GDP-bound form of Arf6 is located at the plasma membrane.
Requirements for CEACAMs and cholesterol during murine coronavirus cell entry.
Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes.
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.
RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.
Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain.
Regulation of a COPII component by cytosolic O-glycosylation during mitosis.
Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains.
Recombinant Escherichia coli as a gene delivery vector into airway epithelial cells.
AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells.
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement.
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement.
Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes.
Charge-based separation of detergent-resistant membranes of mouse splenic B cells.
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.
The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.
The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton.
BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.
Multiple regions contribute to membrane targeting of Rab GTPases.
Cellular senescence induced loss of stem cell proportion in the skin in vitro.
Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.
Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis.
T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.
T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.
Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation.
Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.
Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain.
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Lipid raft-associated protein sorting in exosomes.
The role of c-Src in platelet-derived growth factor alpha receptor internalization.
Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions.
Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions.
Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.
Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.
Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.
A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.
A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.
Association of human transferrin receptor with GABARAP.
Association of human transferrin receptor with GABARAP.
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain.
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain.
Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling.
Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling.
Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.
Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling.
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling.
Afipia felis induces uptake by macrophages directly into a nonendocytic compartment.
Antigen loading of MHC class I molecules in the endocytic tract.
Antigen loading of MHC class I molecules in the endocytic tract.
Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains.
Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells.
Rab15 differentially regulates early endocytic trafficking.
E3-13.7 integral membrane proteins encoded by human adenoviruses alter epidermal growth factor receptor trafficking by interacting directly with receptors in early endosomes.
E3-13.7 integral membrane proteins encoded by human adenoviruses alter epidermal growth factor receptor trafficking by interacting directly with receptors in early endosomes.
Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.
Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.
Brefeldin A-dependent membrane tubule formation reconstituted in vitro is driven by a cell cycle-regulated microtubule motor.
Brefeldin A-dependent membrane tubule formation reconstituted in vitro is driven by a cell cycle-regulated microtubule motor.
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107.
The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components.
The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components.
Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae.
High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.
Development, characterization, and use of monoclonal antibodies made to antigens expressed on the surface of fetal nucleated red blood cells.
Membrane trafficking regulates the activity of the human dopamine transporter.
Membrane trafficking regulates the activity of the human dopamine transporter.
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle.
Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle.
Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.
Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.
Separation and partial characterization of three distinct intracellular GLUT4 compartments in rat adipocytes. Subcellular fractionation without homogenization.
Rab15 mediates an early endocytic event in Chinese hamster ovary cells.
Rab15 mediates an early endocytic event in Chinese hamster ovary cells.
KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation.
The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
Transferrin and transferrin receptor in human hypophysis and pituitary adenomas.
Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.
Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.
Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN.
Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN.
Prael Iii FJ, Kim K, Du Y, Spitznagel BD, Sulikowski GA, Delpire E, Weaver CD
Frontiers in cell and developmental biology 2022;10:912812
Frontiers in cell and developmental biology 2022;10:912812
Endocytosis in the axon initial segment maintains neuronal polarity.
Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, Südhof TC, Malenka R, Wernig M, Özkan E, Perrais D, Shen K
Nature 2022 Sep;609(7925):128-135
Nature 2022 Sep;609(7925):128-135
The epilepsy-associated protein PCDH19 undergoes NMDA receptor-dependent proteolytic cleavage and regulates the expression of immediate-early genes.
Gerosa L, Mazzoleni S, Rusconi F, Longaretti A, Lewerissa E, Pelucchi S, Murru L, Giannelli SG, Broccoli V, Marcello E, Kasri NN, Battaglioli E, Passafaro M, Bassani S
Cell reports 2022 May 24;39(8):110857
Cell reports 2022 May 24;39(8):110857
Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167.
Ghilarducci K, Cabana VC, Harake A, Cappadocia L, Lussier MP
International journal of molecular sciences 2022 Jul 16;23(14)
International journal of molecular sciences 2022 Jul 16;23(14)
EGF-SNX3-EGFR axis drives tumor progression and metastasis in triple-negative breast cancers.
Cicek E, Circir A, Oyken M, Akbulut Caliskan O, Dioken DN, Guntekin Ergun S, Cetin-Atalay R, Sapmaz A, Ovaa H, Sahin O, Erson-Bensan AE
Oncogene 2022 Jan;41(2):220-232
Oncogene 2022 Jan;41(2):220-232
Lung emphysema and impaired macrophage elastase clearance in mucolipin 3 deficient mice.
Spix B, Butz ES, Chen CC, Rosato AS, Tang R, Jeridi A, Kudrina V, Plesch E, Wartenberg P, Arlt E, Briukhovetska D, Ansari M, Günsel GG, Conlon TM, Wyatt A, Wetzel S, Teupser D, Holdt LM, Ectors F, Boekhoff I, Boehm U, García-Añoveros J, Saftig P, Giera M, Kobold S, Schiller HB, Zierler S, Gudermann T, Wahl-Schott C, Bracher F, Yildirim AÖ, Biel M, Grimm C
Nature communications 2022 Jan 14;13(1):318
Nature communications 2022 Jan 14;13(1):318
SNAP23 regulates KCC2 membrane insertion and activity following mZnR/GPR39 activation in hippocampalneurons.
Asraf H, Bogdanovic M, Gottesman N, Sekler I, Aizenman E, Hershfinkel M
iScience 2022 Feb 18;25(2):103751
iScience 2022 Feb 18;25(2):103751
ALFY localizes to early endosomes and cellular protrusions to facilitate directional cell migration.
Søreng K, Pankiv S, Bergsmark C, Haugsten EM, Dahl AK, de la Ballina LR, Yamamoto A, Lystad AH, Simonsen A
Journal of cell science 2022 Feb 15;135(4)
Journal of cell science 2022 Feb 15;135(4)
Immunomagnetic microscopy of tumor tissues using quantum sensors in diamond.
Chen S, Li W, Zheng X, Yu P, Wang P, Sun Z, Xu Y, Jiao D, Ye X, Cai M, Shen M, Wang M, Zhang Q, Kong F, Wang Y, He J, Wei H, Shi F, Du J
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 1;119(5)
Proceedings of the National Academy of Sciences of the United States of America 2022 Feb 1;119(5)
Transposon-activated POU5F1B promotes colorectal cancer growth and metastasis.
Simó-Riudalbas L, Offner S, Planet E, Duc J, Abrami L, Dind S, Coudray A, Coto-Llerena M, Ercan C, Piscuoglio S, Andersen CL, Bramsen JB, Trono D
Nature communications 2022 Aug 20;13(1):4913
Nature communications 2022 Aug 20;13(1):4913
Canonical Wnt signaling induces focal adhesion and Integrin beta-1 endocytosis.
Tejeda-Muñoz N, Morselli M, Moriyama Y, Sheladiya P, Pellegrini M, De Robertis EM
iScience 2022 Apr 15;25(4):104123
iScience 2022 Apr 15;25(4):104123
Correlation Analyses of Clinical Manifestations and Variant Effects in KCNB1-Related Neurodevelopmental Disorder.
Xiong J, Liu Z, Chen S, Kessi M, Chen B, Duan H, Deng X, Yang L, Peng J, Yin F
Frontiers in pediatrics 2021;9:755344
Frontiers in pediatrics 2021;9:755344
Deferoxamine Counteracts Cisplatin Resistance in A549 Lung Adenocarcinoma Cells by Increasing Vulnerability to Glutamine Deprivation-Induced Cell Death.
Liu WJ, Pan PY, Sun Y, Wang JB, Zhou H, Xie X, Duan ZY, Dong HY, Chen WN, Zhang LD, Wang C
Frontiers in oncology 2021;11:794735
Frontiers in oncology 2021;11:794735
Assembly of γ-secretase occurs through stable dimers after exit from the endoplasmic reticulum.
Wouters R, Michiels C, Sannerud R, Kleizen B, Dillen K, Vermeire W, Ayala AE, Demedts D, Schekman R, Annaert W
The Journal of cell biology 2021 Sep 6;220(9)
The Journal of cell biology 2021 Sep 6;220(9)
The Lipogenic Regulator SREBP2 Induces Transferrin in Circulating Melanoma Cells and Suppresses Ferroptosis.
Hong X, Roh W, Sullivan RJ, Wong KHK, Wittner BS, Guo H, Dubash TD, Sade-Feldman M, Wesley B, Horwitz E, Boland GM, Marvin DL, Bonesteel T, Lu C, Aguet F, Burr R, Freeman SS, Parida L, Calhoun K, Jewett MK, Nieman LT, Hacohen N, Näär AM, Ting DT, Toner M, Stott SL, Getz G, Maheswaran S, Haber DA
Cancer discovery 2021 Mar;11(3):678-695
Cancer discovery 2021 Mar;11(3):678-695
Knocking out alpha-synuclein in melanoma cells dysregulates cellular iron metabolism and suppresses tumor growth.
Shekoohi S, Rajasekaran S, Patel D, Yang S, Liu W, Huang S, Yu X, Witt SN
Scientific reports 2021 Mar 4;11(1):5267
Scientific reports 2021 Mar 4;11(1):5267
Evaluation of TFR-1 Expression in Feline Mammary Cancer and In Vitro Antitumor Efficacy Study of Doxorubicin-Loaded H-Ferritin Nanocages.
Rensi N, Sammarco A, Moccia V, Calore A, Torrigiani F, Prosperi D, Rizzuto MA, Bellini M, De Maria R, Bonsembiante F, Ferro S, Zanetti R, Zappulli V, Cavicchioli L
Cancers 2021 Mar 12;13(6)
Cancers 2021 Mar 12;13(6)
CD97 stabilises the immunological synapse between dendritic cells and T cells and is targeted for degradation by the Salmonella effector SteD.
Cerny O, Godlee C, Tocci R, Cross NE, Shi H, Williamson JC, Alix E, Lehner PJ, Holden DW
PLoS pathogens 2021 Jul;17(7):e1009771
PLoS pathogens 2021 Jul;17(7):e1009771
Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides.
Huang H, Tay SH, Ng W, Ng SY, Soong TW
Pain 2021 Jul 1;162(7):2097-2109
Pain 2021 Jul 1;162(7):2097-2109
The UFM1 Pathway Impacts HCMV US2-Mediated Degradation of HLA Class I.
Schuren ABC, Boer IGJ, Bouma EM, Van de Weijer ML, Costa AI, Hubel P, Pichlmair A, Lebbink RJ, Wiertz EJHJ
Molecules (Basel, Switzerland) 2021 Jan 8;26(2)
Molecules (Basel, Switzerland) 2021 Jan 8;26(2)
Plasma Membrane Calcium ATPase-Neuroplastin Complexes Are Selectively Stabilized in GM1-Containing Lipid Rafts.
Ilic K, Lin X, Malci A, Stojanović M, Puljko B, Rožman M, Vukelić Ž, Heffer M, Montag D, Schnaar RL, Kalanj-Bognar S, Herrera-Molina R, Mlinac-Jerkovic K
International journal of molecular sciences 2021 Dec 18;22(24)
International journal of molecular sciences 2021 Dec 18;22(24)
Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity.
Zhang Z, Funcke JB, Zi Z, Zhao S, Straub LG, Zhu Y, Zhu Q, Crewe C, An YA, Chen S, Li N, Wang MY, Ghaben AL, Lee C, Gautron L, Engelking LJ, Raj P, Deng Y, Gordillo R, Kusminski CM, Scherer PE
Cell metabolism 2021 Aug 3;33(8):1624-1639.e9
Cell metabolism 2021 Aug 3;33(8):1624-1639.e9
SARS-CoV-2 infects human pancreatic β cells and elicits β cell impairment.
Wu CT, Lidsky PV, Xiao Y, Lee IT, Cheng R, Nakayama T, Jiang S, Demeter J, Bevacqua RJ, Chang CA, Whitener RL, Stalder AK, Zhu B, Chen H, Goltsev Y, Tzankov A, Nayak JV, Nolan GP, Matter MS, Andino R, Jackson PK
Cell metabolism 2021 Aug 3;33(8):1565-1576.e5
Cell metabolism 2021 Aug 3;33(8):1565-1576.e5
Localization and Kinetics of the Transferrin-Dependent Iron Transport Machinery in the Mouse Placenta.
Cao C, Fleming MD
Current developments in nutrition 2021 Apr;5(4):nzab025
Current developments in nutrition 2021 Apr;5(4):nzab025
RBD11, a bioengineered Rab11-binding module for visualizing and analyzing endogenous Rab11.
Osaki F, Matsui T, Hiragi S, Homma Y, Fukuda M
Journal of cell science 2021 Apr 1;134(7)
Journal of cell science 2021 Apr 1;134(7)
β-Phenethyl Isothiocyanate Induces Cell Death in Human Osteosarcoma through Altering Iron Metabolism, Disturbing the Redox Balance, and Activating the MAPK Signaling Pathway.
Lv H, Zhen C, Liu J, Shang P
Oxidative medicine and cellular longevity 2020;2020:5021983
Oxidative medicine and cellular longevity 2020;2020:5021983
Kidney Ischemia/Reperfusion Injury Induces Changes in the Drug Transporter Expression at the Blood-Brain Barrier in vivo and in vitro.
Burek M, Burmester S, Salvador E, Möller-Ehrlich K, Schneider R, Roewer N, Nagai M, Förster CY
Frontiers in physiology 2020;11:569881
Frontiers in physiology 2020;11:569881
Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice.
Castellanos DM, Sun J, Yang J, Ou W, Zambon AC, Pardridge WM, Sumbria RK
Pharmaceutics 2020 Sep 8;12(9)
Pharmaceutics 2020 Sep 8;12(9)
Heme Oxygenase-1 Supports Mitochondrial Energy Production and Electron Transport Chain Activity in Cultured Lung Epithelial Cells.
Carr JF, Garcia D, Scaffa A, Peterson AL, Ghio AJ, Dennery PA
International journal of molecular sciences 2020 Sep 22;21(18)
International journal of molecular sciences 2020 Sep 22;21(18)
PAG1 directs SRC-family kinase intracellular localization to mediate receptor tyrosine kinase-induced differentiation.
Foltz L, Palacios-Moreno J, Mayfield M, Kinch S, Dillon J, Syrenne J, Levy T, Grimes M
Molecular biology of the cell 2020 Sep 15;31(20):2269-2282
Molecular biology of the cell 2020 Sep 15;31(20):2269-2282
CD44 regulates epigenetic plasticity by mediating iron endocytosis.
Müller S, Sindikubwabo F, Cañeque T, Lafon A, Versini A, Lombard B, Loew D, Wu TD, Ginestier C, Charafe-Jauffret E, Durand A, Vallot C, Baulande S, Servant N, Rodriguez R
Nature chemistry 2020 Oct;12(10):929-938
Nature chemistry 2020 Oct;12(10):929-938
Therapeutic effect of a histone demethylase inhibitor in Parkinson's disease.
Mu MD, Qian ZM, Yang SX, Rong KL, Yung WH, Ke Y
Cell death & disease 2020 Oct 28;11(10):927
Cell death & disease 2020 Oct 28;11(10):927
RNA localization and co-translational interactions control RAB13 GTPase function and cell migration.
Moissoglu K, Stueland M, Gasparski AN, Wang T, Jenkins LM, Hastings ML, Mili S
The EMBO journal 2020 Nov 2;39(21):e104958
The EMBO journal 2020 Nov 2;39(21):e104958
Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder.
Kwan STC, Kezer CA, Helfrich KK, Saini N, Huebner SM, Flentke GR, Kling PJ, Smith SM
Alcohol (Fayetteville, N.Y.) 2020 May;84:57-66
Alcohol (Fayetteville, N.Y.) 2020 May;84:57-66
Novel multifunctional iron chelators of the aroyl nicotinoyl hydrazone class that markedly enhance cellular NAD(+) /NADH ratios.
Wu Z, Palanimuthu D, Braidy N, Salikin NH, Egan S, Huang MLH, Richardson DR
British journal of pharmacology 2020 May;177(9):1967-1987
British journal of pharmacology 2020 May;177(9):1967-1987
Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration.
Weinert S, Gimber N, Deuschel D, Stuhlmann T, Puchkov D, Farsi Z, Ludwig CF, Novarino G, López-Cayuqueo KI, Planells-Cases R, Jentsch TJ
The EMBO journal 2020 May 4;39(9):e103358
The EMBO journal 2020 May 4;39(9):e103358
Measuring ligand-cell surface receptor affinities with axial line-scanning fluorescence correlation spectroscopy.
Eckert AF, Gao P, Wesslowski J, Wang X, Rath J, Nienhaus K, Davidson G, Nienhaus GU
eLife 2020 May 22;9
eLife 2020 May 22;9
Two Functional Variants of AP-1 Complexes Composed of either γ2 or γ1 Subunits Are Independently Required for Major Histocompatibility Complex Class I Downregulation by HIV-1 Nef.
Tavares LA, de Carvalho JV, Costa CS, Silveira RM, de Carvalho AN, Donadi EA, daSilva LLP
Journal of virology 2020 Mar 17;94(7)
Journal of virology 2020 Mar 17;94(7)
Transferrin Receptor Is a Specific Ferroptosis Marker.
Feng H, Schorpp K, Jin J, Yozwiak CE, Hoffstrom BG, Decker AM, Rajbhandari P, Stokes ME, Bender HG, Csuka JM, Upadhyayula PS, Canoll P, Uchida K, Soni RK, Hadian K, Stockwell BR
Cell reports 2020 Mar 10;30(10):3411-3423.e7
Cell reports 2020 Mar 10;30(10):3411-3423.e7
SQSTM1/p62 and PPARGC1A/PGC-1alpha at the interface of autophagy and vascular senescence.
Salazar G, Cullen A, Huang J, Zhao Y, Serino A, Hilenski L, Patrushev N, Forouzandeh F, Hwang HS
Autophagy 2020 Jun;16(6):1092-1110
Autophagy 2020 Jun;16(6):1092-1110
Regulation of bile duct epithelial injury by hepatic CD71+ erythroid cells.
Yang L, Shivakumar P, Kinder J, Way SS, Donnelly B, Mourya R, Luo Z, Bezerra JA
JCI insight 2020 Jun 4;5(11)
JCI insight 2020 Jun 4;5(11)
A Cluster of Autism-Associated Variants on X-Linked NLGN4X Functionally Resemble NLGN4Y.
Nguyen TA, Wu K, Pandey S, Lehr AW, Li Y, Bemben MA, Badger JD 2nd, Lauzon JL, Wang T, Zaghloul KA, Thurm A, Jain M, Lu W, Roche KW
Neuron 2020 Jun 3;106(5):759-768.e7
Neuron 2020 Jun 3;106(5):759-768.e7
The NMDA receptor subunit GluN3A regulates synaptic activity-induced and myocyte enhancer factor 2C (MEF2C)-dependent transcription.
Chen LF, Lyons MR, Liu F, Green MV, Hedrick NG, Williams AB, Narayanan A, Yasuda R, West AE
The Journal of biological chemistry 2020 Jun 19;295(25):8613-8627
The Journal of biological chemistry 2020 Jun 19;295(25):8613-8627
The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules.
Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, Liu M, Pruneda JN, Swatek KN, Komander D, Sleap T, Holden DW
Cell host & microbe 2020 Jul 8;28(1):54-68.e7
Cell host & microbe 2020 Jul 8;28(1):54-68.e7
Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/γ-secretase at the cell surface.
Escamilla-Ayala AA, Sannerud R, Mondin M, Poersch K, Vermeire W, Paparelli L, Berlage C, Koenig M, Chavez-Gutierrez L, Ulbrich MH, Munck S, Mizuno H, Annaert W
eLife 2020 Jul 7;9
eLife 2020 Jul 7;9
Brain Hepcidin Suppresses Major Pathologies in Experimental Parkinsonism.
Liang T, Qian ZM, Mu MD, Yung WH, Ke Y
iScience 2020 Jul 24;23(7):101284
iScience 2020 Jul 24;23(7):101284
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human.
Zhang W, Liu QY, Haqqani AS, Leclerc S, Liu Z, Fauteux F, Baumann E, Delaney CE, Ly D, Star AT, Brunette E, Sodja C, Hewitt M, Sandhu JK, Stanimirovic DB
Fluids and barriers of the CNS 2020 Jul 22;17(1):47
Fluids and barriers of the CNS 2020 Jul 22;17(1):47
Mechanisms of site-specific dephosphorylation and kinase opposition imposed by PP2A regulatory subunits.
Kruse T, Gnosa SP, Nasa I, Garvanska DH, Hein JB, Nguyen H, Samsøe-Petersen J, Lopez-Mendez B, Hertz EPT, Schwarz J, Pena HS, Nikodemus D, Kveiborg M, Kettenbach AN, Nilsson J
The EMBO journal 2020 Jul 1;39(13):e103695
The EMBO journal 2020 Jul 1;39(13):e103695
Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal.
Jia J, Claude-Taupin A, Gu Y, Choi SW, Peters R, Bissa B, Mudd MH, Allers L, Pallikkuth S, Lidke KA, Salemi M, Phinney B, Mari M, Reggiori F, Deretic V
Developmental cell 2020 Jan 6;52(1):69-87.e8
Developmental cell 2020 Jan 6;52(1):69-87.e8
Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice.
Yasumura S, Naito Y, Okuno K, Sawada H, Asakura M, Masuyama T, Ishihara M
Hypertension (Dallas, Tex. : 1979) 2020 Feb;75(2):413-421
Hypertension (Dallas, Tex. : 1979) 2020 Feb;75(2):413-421
Recycling endosomes attach to the trans-side of Golgi stacks in Drosophila and mammalian cells.
Fujii S, Kurokawa K, Inaba R, Hiramatsu N, Tago T, Nakamura Y, Nakano A, Satoh T, Satoh AK
Journal of cell science 2020 Feb 26;133(4)
Journal of cell science 2020 Feb 26;133(4)
De Novo VPS4A Mutations Cause Multisystem Disease with Abnormal Neurodevelopment.
Rodger C, Flex E, Allison RJ, Sanchis-Juan A, Hasenahuer MA, Cecchetti S, French CE, Edgar JR, Carpentieri G, Ciolfi A, Pantaleoni F, Bruselles A, Genomics England Research Consortium, Onesimo R, Zampino G, Marcon F, Siniscalchi E, Lees M, Krishnakumar D, McCann E, Yosifova D, Jarvis J, Kruer MC, Marks W, Campbell J, Allen LE, Gustincich S, Raymond FL, Tartaglia M, Reid E
American journal of human genetics 2020 Dec 3;107(6):1129-1148
American journal of human genetics 2020 Dec 3;107(6):1129-1148
Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis.
Verma N, Vinik Y, Saroha A, Nair NU, Ruppin E, Mills G, Karn T, Dubey V, Khera L, Raj H, Maina F, Lev S
Science advances 2020 Aug;6(34)
Science advances 2020 Aug;6(34)
Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed.
Renassia C, Louis S, Cuvellier S, Boussetta N, Deschemin JC, Borderie D, Bailly K, Poupon J, Dang PM, El-Benna J, Manceau S, Lefrère F, Vaulont S, Peyssonnaux C
Blood advances 2020 Aug 25;4(16):3853-3863
Blood advances 2020 Aug 25;4(16):3853-3863
Mammalian copper homeostasis requires retromer-dependent recycling of the high-affinity copper transporter 1.
Curnock R, Cullen PJ
Journal of cell science 2020 Aug 25;133(16)
Journal of cell science 2020 Aug 25;133(16)
Up-regulation of voltage-gated sodium channels by peptides mimicking S4-S5 linkers reveals a variation of the ligand-receptor mechanism.
Malak OA, Abderemane-Ali F, Wei Y, Coyan FC, Pontus G, Shaya D, Marionneau C, Loussouarn G
Scientific reports 2020 Apr 3;10(1):5852
Scientific reports 2020 Apr 3;10(1):5852
Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.
Curtaz CJ, Schmitt C, Herbert SL, Feldheim J, Schlegel N, Gosselet F, Hagemann C, Roewer N, Meybohm P, Wöckel A, Burek M
Fluids and barriers of the CNS 2020 Apr 22;17(1):31
Fluids and barriers of the CNS 2020 Apr 22;17(1):31
Dietary lipids fuel GPX4-restricted enteritis resembling Crohn's disease.
Mayr L, Grabherr F, Schwärzler J, Reitmeier I, Sommer F, Gehmacher T, Niederreiter L, He GW, Ruder B, Kunz KTR, Tymoszuk P, Hilbe R, Haschka D, Feistritzer C, Gerner RR, Enrich B, Przysiecki N, Seifert M, Keller MA, Oberhuber G, Sprung S, Ran Q, Koch R, Effenberger M, Tancevski I, Zoller H, Moschen AR, Weiss G, Becker C, Rosenstiel P, Kaser A, Tilg H, Adolph TE
Nature communications 2020 Apr 14;11(1):1775
Nature communications 2020 Apr 14;11(1):1775
Delineating the role of FANCA in glucose-stimulated insulin secretion in β cells through its protein interactome.
Lagundžin D, Hu WF, Law HCH, Krieger KL, Qiao F, Clement EJ, Drincic AT, Nedić O, Naldrett MJ, Alvarez S, Woods NT
PloS one 2019;14(8):e0220568
PloS one 2019;14(8):e0220568
Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells.
Chadchankar J, Korboukh V, Conway LC, Wobst HJ, Walker CA, Doig P, Jacobsen SJ, Brandon NJ, Moss SJ, Wang Q
PloS one 2019;14(11):e0225145
PloS one 2019;14(11):e0225145
Downregulation of TfR1 promotes progression of colorectal cancer via the JAK/STAT pathway.
Cui C, Cheng X, Yan L, Ding H, Guan X, Zhang W, Tian X, Hao C
Cancer management and research 2019;11:6323-6341
Cancer management and research 2019;11:6323-6341
Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis.
Maio N, Kim KS, Holmes-Hampton G, Singh A, Rouault TA
Haematologica 2019 Sep;104(9):1756-1767
Haematologica 2019 Sep;104(9):1756-1767
Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD
The Journal of biological chemistry 2019 Sep 6;294(36):13292-13303
The Journal of biological chemistry 2019 Sep 6;294(36):13292-13303
Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia.
Okuno K, Naito Y, Yasumura S, Sawada H, Asakura M, Masuyama T, Ishihara M
Scientific reports 2019 Sep 20;9(1):13658
Scientific reports 2019 Sep 20;9(1):13658
Iron overload inhibits late stage autophagic flux leading to insulin resistance.
Jahng JWS, Alsaadi RM, Palanivel R, Song E, Hipolito VEB, Sung HK, Botelho RJ, Russell RC, Sweeney G
EMBO reports 2019 Oct 4;20(10):e47911
EMBO reports 2019 Oct 4;20(10):e47911
SH3YL1 cooperates with ESCRT-I in the sorting and degradation of the EGF receptor.
Hasegawa J, Jebri I, Yamamoto H, Tsujita K, Tokuda E, Shibata H, Maki M, Itoh T
Journal of cell science 2019 Oct 3;132(19)
Journal of cell science 2019 Oct 3;132(19)
The LMTK1-TBC1D9B-Rab11A Cascade Regulates Dendritic Spine Formation via Endosome Trafficking.
Nishino H, Saito T, Wei R, Takano T, Tsutsumi K, Taniguchi M, Ando K, Tomomura M, Fukuda M, Hisanaga SI
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Nov 27;39(48):9491-9502
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Nov 27;39(48):9491-9502
Serotonin 5-HT(2C) Receptor Cys23Ser Single Nucleotide Polymorphism Associates with Receptor Function and Localization In Vitro.
Land MA, Chapman HL, Davis-Reyes BD, Felsing DE, Allen JA, Moeller FG, Elferink LA, Cunningham KA, Anastasio NC
Scientific reports 2019 Nov 13;9(1):16737
Scientific reports 2019 Nov 13;9(1):16737
Efficacy of ruthenium coordination complex-based Rutherrin in a preclinical rat glioblastoma model.
Munegowda MA, Fisher C, Molehuis D, Foltz W, Roufaiel M, Bassan J, Nitz M, Mandel A, Lilge L
Neuro-oncology advances 2019 May-Dec;1(1):vdz006
Neuro-oncology advances 2019 May-Dec;1(1):vdz006
Systems Analysis of the 22q11.2 Microdeletion Syndrome Converges on a Mitochondrial Interactome Necessary for Synapse Function and Behavior.
Gokhale A, Hartwig C, Freeman AAH, Bassell JL, Zlatic SA, Sapp Savas C, Vadlamudi T, Abudulai F, Pham TT, Crocker A, Werner E, Wen Z, Repetto GM, Gogos JA, Claypool SM, Forsyth JK, Bearden CE, Glausier J, Lewis DA, Seyfried NT, Kwong JQ, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 May 1;39(18):3561-3581
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 May 1;39(18):3561-3581
Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion.
Komura H, Kakio S, Sasahara T, Arai Y, Takino N, Sato M, Satomura K, Ohnishi T, Nabeshima YI, Muramatsu SI, Kii I, Hoshi M
iScience 2019 Mar 29;13:452-477
iScience 2019 Mar 29;13:452-477
GRASP depletion-mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin.
Ahat E, Xiang Y, Zhang X, Bekier ME 2nd, Wang Y
Molecular biology of the cell 2019 Mar 15;30(6):766-777
Molecular biology of the cell 2019 Mar 15;30(6):766-777
Disturbed neurotransmitter homeostasis in ether lipid deficiency.
Dorninger F, König T, Scholze P, Berger ML, Zeitler G, Wiesinger C, Gundacker A, Pollak DD, Huck S, Just WW, Forss-Petter S, Pifl C, Berger J
Human molecular genetics 2019 Jun 15;28(12):2046-2061
Human molecular genetics 2019 Jun 15;28(12):2046-2061
Drug-induced increase in lysobisphosphatidic acid reduces the cholesterol overload in Niemann-Pick type C cells and mice.
Moreau D, Vacca F, Vossio S, Scott C, Colaco A, Paz Montoya J, Ferguson C, Damme M, Moniatte M, Parton RG, Platt FM, Gruenberg J
EMBO reports 2019 Jul;20(7):e47055
EMBO reports 2019 Jul;20(7):e47055
An in vitro FcRn- dependent transcytosis assay as a screening tool for predictive assessment of nonspecific clearance of antibody therapeutics in humans.
Chung S, Nguyen V, Lin YL, Lafrance-Vanasse J, Scales SJ, Lin K, Deng R, Williams K, Sperinde G, Li JJ, Zheng K, Sukumaran S, Tesar D, Ernst JA, Fischer S, Lazar GA, Prabhu S, Song A
mAbs 2019 Jul;11(5):942-955
mAbs 2019 Jul;11(5):942-955
Neurolastin, a dynamin family GTPase, translocates to mitochondria upon neuronal stress and alters mitochondrial morphology in vivo.
Lomash RM, Petralia RS, Holtzclaw LA, Tsuda MC, Wang YX, Badger JD 2nd, Cameron HA, Youle RJ, Roche KW
The Journal of biological chemistry 2019 Jul 26;294(30):11498-11512
The Journal of biological chemistry 2019 Jul 26;294(30):11498-11512
Identification and therapeutic rescue of autophagosome and glutamate receptor defects in C9ORF72 and sporadic ALS neurons.
Shi Y, Hung ST, Rocha G, Lin S, Linares GR, Staats KA, Seah C, Wang Y, Chickering M, Lai J, Sugawara T, Sagare AP, Zlokovic BV, Ichida JK
JCI insight 2019 Jul 16;5(15)
JCI insight 2019 Jul 16;5(15)
Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload.
Schwartz AJ, Das NK, Ramakrishnan SK, Jain C, Jurkovic MT, Wu J, Nemeth E, Lakhal-Littleton S, Colacino JA, Shah YM
The Journal of clinical investigation 2019 Jan 2;129(1):336-348
The Journal of clinical investigation 2019 Jan 2;129(1):336-348
miR-148a regulates expression of the transferrin receptor 1 in hepatocellular carcinoma.
Babu KR, Muckenthaler MU
Scientific reports 2019 Feb 6;9(1):1518
Scientific reports 2019 Feb 6;9(1):1518
ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin.
Saaber F, Schütz D, Miess E, Abe P, Desikan S, Ashok Kumar P, Balk S, Huang K, Beaulieu JM, Schulz S, Stumm R
Cell reports 2019 Feb 5;26(6):1473-1488.e9
Cell reports 2019 Feb 5;26(6):1473-1488.e9
TRPM4-specific blocking antibody attenuates reperfusion injury in a rat model of stroke.
Chen B, Gao Y, Wei S, Low SW, Ng G, Yu D, Tu TM, Soong TW, Nilius B, Liao P
Pflugers Archiv : European journal of physiology 2019 Dec;471(11-12):1455-1466
Pflugers Archiv : European journal of physiology 2019 Dec;471(11-12):1455-1466
4'-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN.
Jeong SY, Hogarth P, Placzek A, Gregory AM, Fox R, Zhen D, Hamada J, van der Zwaag M, Lambrechts R, Jin H, Nilsen A, Cobb J, Pham T, Gray N, Ralle M, Duffy M, Schwanemann L, Rai P, Freed A, Wakeman K, Woltjer RL, Sibon OC, Hayflick SJ
EMBO molecular medicine 2019 Dec;11(12):e10489
EMBO molecular medicine 2019 Dec;11(12):e10489
Sideroflexin 4 affects Fe-S cluster biogenesis, iron metabolism, mitochondrial respiration and heme biosynthetic enzymes.
Paul BT, Tesfay L, Winkler CR, Torti FM, Torti SV
Scientific reports 2019 Dec 23;9(1):19634
Scientific reports 2019 Dec 23;9(1):19634
A causal role for TRESK loss of function in migraine mechanisms.
Pettingill P, Weir GA, Wei T, Wu Y, Flower G, Lalic T, Handel A, Duggal G, Chintawar S, Cheung J, Arunasalam K, Couper E, Haupt LM, Griffiths LR, Bassett A, Cowley SA, Cader MZ
Brain : a journal of neurology 2019 Dec 1;142(12):3852-3867
Brain : a journal of neurology 2019 Dec 1;142(12):3852-3867
Quantitative proteomics reveals reduction of endocytic machinery components in gliomas.
Buser DP, Ritz MF, Moes S, Tostado C, Frank S, Spiess M, Mariani L, Jenö P, Boulay JL, Hutter G
EBioMedicine 2019 Aug;46:32-41
EBioMedicine 2019 Aug;46:32-41
Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABA(A) receptors.
Parakala ML, Zhang Y, Modgil A, Chadchankar J, Vien TN, Ackley MA, Doherty JJ, Davies PA, Moss SJ
The Journal of biological chemistry 2019 Aug 9;294(32):12220-12230
The Journal of biological chemistry 2019 Aug 9;294(32):12220-12230
Sex-regulated gene dosage effect of PPARα on synaptic plasticity.
Pierrot N, Ris L, Stancu IC, Doshina A, Ribeiro F, Tyteca D, Baugé E, Lalloyer F, Malong L, Schakman O, Leroy K, Kienlen-Campard P, Gailly P, Brion JP, Dewachter I, Staels B, Octave JN
Life science alliance 2019 Apr;2(2)
Life science alliance 2019 Apr;2(2)
Proximal tubule transferrin uptake is modulated by cellular iron and mediated by apical membrane megalin-cubilin complex and transferrin receptor 1.
Smith CP, Lee WK, Haley M, Poulsen SB, Thévenod F, Fenton RA
The Journal of biological chemistry 2019 Apr 26;294(17):7025-7036
The Journal of biological chemistry 2019 Apr 26;294(17):7025-7036
Extracellular small non-coding RNA contaminants in fetal bovine serum and serum-free media.
Mannerström B, Paananen RO, Abu-Shahba AG, Moilanen J, Seppänen-Kaijansinkko R, Kaur S
Scientific reports 2019 Apr 2;9(1):5538
Scientific reports 2019 Apr 2;9(1):5538
Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis.
Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H, Moriya K, Koike K, Mimori K, Mori M, Katayama Y, Nakayama KI
The Journal of experimental medicine 2019 Apr 1;216(4):950-965
The Journal of experimental medicine 2019 Apr 1;216(4):950-965
Epithelial Keratins Modulate cMet Expression and Signaling and Promote InlB-Mediated Listeria monocytogenes Infection of HeLa Cells.
Cruz R, Pereira-Castro I, Almeida MT, Moreira A, Cabanes D, Sousa S
Frontiers in cellular and infection microbiology 2018;8:146
Frontiers in cellular and infection microbiology 2018;8:146
Efficient ultrafiltration-based protocol to deplete extracellular vesicles from fetal bovine serum.
Kornilov R, Puhka M, Mannerström B, Hiidenmaa H, Peltoniemi H, Siljander P, Seppänen-Kaijansinkko R, Kaur S
Journal of extracellular vesicles 2018;7(1):1422674
Journal of extracellular vesicles 2018;7(1):1422674
New cases of Glucose-6-Phosphate Dehydrogenase deficiency in Pulmonary Arterial Hypertension.
Kurdyukov S, Eccles CA, Desai AA, Gonzalez-Garay M, Yuan JX, Garcia JGN, Rafikova O, Rafikov R
PloS one 2018;13(8):e0203493
PloS one 2018;13(8):e0203493
SIMPLE binds specifically to PI4P through SIMPLE-like domain and participates in protein trafficking in the trans-Golgi network and/or recycling endosomes.
Moriwaki Y, Ohno Y, Ishii T, Takamura Y, Kita Y, Watabe K, Sango K, Tsuji S, Misawa H
PloS one 2018;13(6):e0199829
PloS one 2018;13(6):e0199829
Ceruloplasmin Plays a Neuroprotective Role in Cerebral Ischemia.
Ryan F, Zarruk JG, Lößlein L, David S
Frontiers in neuroscience 2018;12:988
Frontiers in neuroscience 2018;12:988
Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism.
Modi ME, Brooks JM, Guilmette ER, Beyna M, Graf R, Reim D, Schmeisser MJ, Boeckers TM, O'Donnell P, Buhl DL
Frontiers in molecular neuroscience 2018;11:107
Frontiers in molecular neuroscience 2018;11:107
Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.
Lane DJR, Bae DH, Siafakas AR, Suryo Rahmanto Y, Al-Akra L, Jansson PJ, Casero RA Jr, Richardson DR
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2793-2813
Biochimica et biophysica acta. Molecular basis of disease 2018 Sep;1864(9 Pt B):2793-2813
Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood-brain barrier in vitro is dependent on its binding affinity.
Haqqani AS, Thom G, Burrell M, Delaney CE, Brunette E, Baumann E, Sodja C, Jezierski A, Webster C, Stanimirovic DB
Journal of neurochemistry 2018 Sep;146(6):735-752
Journal of neurochemistry 2018 Sep;146(6):735-752
Caveolin-1 Promotes Early Neuronal Maturation via Caveolae-Independent Trafficking of N-Cadherin and L1.
Shikanai M, Nishimura YV, Sakurai M, Nabeshima YI, Yuzaki M, Kawauchi T
iScience 2018 Sep 28;7:53-67
iScience 2018 Sep 28;7:53-67
Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission.
Ashok A, Karmakar S, Chandel R, Ravikumar R, Dalal S, Kong Q, Singh N
Experimental eye research 2018 Oct;175:1-13
Experimental eye research 2018 Oct;175:1-13
An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor.
Blechingberg J, Poulsen ASA, Kjølby M, Monti G, Allen M, Ivarsen AK, Lincoln SJ, Thotakura G, Vægter CB, Ertekin-Taner N, Nykjær A, Andersen OM
Neurobiology of aging 2018 Nov;71:266.e11-266.e24
Neurobiology of aging 2018 Nov;71:266.e11-266.e24
PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
Schaffer TB, Smith JE, Cook EK, Phan T, Margolis SS
Cell reports 2018 Nov 27;25(9):2470-2483.e8
Cell reports 2018 Nov 27;25(9):2470-2483.e8
CD147 Promotes Entry of Pentamer-Expressing Human Cytomegalovirus into Epithelial and Endothelial Cells.
Vanarsdall AL, Pritchard SR, Wisner TW, Liu J, Jardetzky TS, Johnson DC
mBio 2018 May 8;9(3)
mBio 2018 May 8;9(3)
Sorting nexin 27 (SNX27) regulates the trafficking and activity of the glutamine transporter ASCT2.
Yang Z, Follett J, Kerr MC, Clairfeuille T, Chandra M, Collins BM, Teasdale RD
The Journal of biological chemistry 2018 May 4;293(18):6802-6811
The Journal of biological chemistry 2018 May 4;293(18):6802-6811
Sorting nexin 9 (SNX9) regulates levels of the transmembrane ADAM9 at the cell surface.
Mygind KJ, Störiko T, Freiberg ML, Samsøe-Petersen J, Schwarz J, Andersen OM, Kveiborg M
The Journal of biological chemistry 2018 May 25;293(21):8077-8088
The Journal of biological chemistry 2018 May 25;293(21):8077-8088
A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4(+) T cell-macrophage immunological synapses.
Kasprowicz R, Rand E, O'Toole PJ, Signoret N
Scientific reports 2018 May 22;8(1):8003
Scientific reports 2018 May 22;8(1):8003
Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles.
Lam FC, Morton SW, Wyckoff J, Vu Han TL, Hwang MK, Maffa A, Balkanska-Sinclair E, Yaffe MB, Floyd SR, Hammond PT
Nature communications 2018 May 18;9(1):1991
Nature communications 2018 May 18;9(1):1991
Inflammation-induced iron transport and metabolism by brain microglia.
McCarthy RC, Sosa JC, Gardeck AM, Baez AS, Lee CH, Wessling-Resnick M
The Journal of biological chemistry 2018 May 18;293(20):7853-7863
The Journal of biological chemistry 2018 May 18;293(20):7853-7863
Familial knockin mutation of LRRK2 causes lysosomal dysfunction and accumulation of endogenous insoluble α-synuclein in neurons.
Schapansky J, Khasnavis S, DeAndrade MP, Nardozzi JD, Falkson SR, Boyd JD, Sanderson JB, Bartels T, Melrose HL, LaVoie MJ
Neurobiology of disease 2018 Mar;111:26-35
Neurobiology of disease 2018 Mar;111:26-35
Iron regulatory protein deficiency compromises mitochondrial function in murine embryonic fibroblasts.
Li H, Zhao H, Hao S, Shang L, Wu J, Song C, Meyron-Holtz EG, Qiao T, Li K
Scientific reports 2018 Mar 23;8(1):5118
Scientific reports 2018 Mar 23;8(1):5118
Dietary Iron Fortification Normalizes Fetal Hematology, Hepcidin, and Iron Distribution in a Rat Model of Prenatal Alcohol Exposure.
Huebner SM, Helfrich KK, Saini N, Blohowiak SE, Cheng AA, Kling PJ, Smith SM
Alcoholism, clinical and experimental research 2018 Jun;42(6):1022-1033
Alcoholism, clinical and experimental research 2018 Jun;42(6):1022-1033
FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
Künzel U, Grieve AG, Meng Y, Sieber B, Cowley SA, Freeman M
eLife 2018 Jun 13;7
eLife 2018 Jun 13;7
Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.
Mukadam AS, Breusegem SY, Seaman MNJ
Cellular and molecular life sciences : CMLS 2018 Jul;75(14):2613-2625
Cellular and molecular life sciences : CMLS 2018 Jul;75(14):2613-2625
A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits.
Almeida-Souza L, Frank RAW, García-Nafría J, Colussi A, Gunawardana N, Johnson CM, Yu M, Howard G, Andrews B, Vallis Y, McMahon HT
Cell 2018 Jul 12;174(2):325-337.e14
Cell 2018 Jul 12;174(2):325-337.e14
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.
Hirata T, Mishra SK, Nakamura S, Saito K, Motooka D, Takada Y, Kanzawa N, Murakami Y, Maeda Y, Fujita M, Yamaguchi Y, Kinoshita T
Nature communications 2018 Jan 26;9(1):405
Nature communications 2018 Jan 26;9(1):405
Tuning of delta-protocadherin adhesion through combinatorial diversity.
Bisogni AJ, Ghazanfar S, Williams EO, Marsh HM, Yang JY, Lin DM
eLife 2018 Dec 14;7
eLife 2018 Dec 14;7
SNX18 regulates ATG9A trafficking from recycling endosomes by recruiting Dynamin-2.
Søreng K, Munson MJ, Lamb CA, Bjørndal GT, Pankiv S, Carlsson SR, Tooze SA, Simonsen A
EMBO reports 2018 Apr;19(4)
EMBO reports 2018 Apr;19(4)
Sensitization of TRPV1 receptors by TNF-α orchestrates the development of vincristine-induced pain.
Wang Y, Feng C, He H, He J, Wang J, Li X, Wang S, Li W, Hou J, Liu T, Fang D, Xie SQ
Oncology letters 2018 Apr;15(4):5013-5019
Oncology letters 2018 Apr;15(4):5013-5019
IRS-1 acts as an endocytic regulator of IGF-I receptor to facilitate sustained IGF signaling.
Yoneyama Y, Lanzerstorfer P, Niwa H, Umehara T, Shibano T, Yokoyama S, Chida K, Weghuber J, Hakuno F, Takahashi SI
eLife 2018 Apr 11;7
eLife 2018 Apr 11;7
Matriptase-2 deficiency protects from obesity by modulating iron homeostasis.
Folgueras AR, Freitas-Rodríguez S, Ramsay AJ, Garabaya C, Rodríguez F, Velasco G, López-Otín C
Nature communications 2018 Apr 10;9(1):1350
Nature communications 2018 Apr 10;9(1):1350
Pulmonary Iron Homeostasis in Hepcidin Knockout Mice.
Deschemin JC, Mathieu JRR, Zumerle S, Peyssonnaux C, Vaulont S
Frontiers in physiology 2017;8:804
Frontiers in physiology 2017;8:804
Ferrous Iron Up-regulation in Fibroblasts of Patients with Beta Propeller Protein-Associated Neurodegeneration (BPAN).
Ingrassia R, Memo M, Garavaglia B
Frontiers in genetics 2017;8:18
Frontiers in genetics 2017;8:18
High-Content Imaging Reveals Expansion of the Endosomal Compartment during Coxiella burnetii Parasitophorous Vacuole Maturation.
Larson CL, Heinzen RA
Frontiers in cellular and infection microbiology 2017;7:48
Frontiers in cellular and infection microbiology 2017;7:48
iPSC-derived neuronal models of PANK2-associated neurodegeneration reveal mitochondrial dysfunction contributing to early disease.
Arber C, Angelova PR, Wiethoff S, Tsuchiya Y, Mazzacuva F, Preza E, Bhatia KP, Mills K, Gout I, Abramov AY, Hardy J, Duce JA, Houlden H, Wray S
PloS one 2017;12(9):e0184104
PloS one 2017;12(9):e0184104
TBC1D12 is a novel Rab11-binding protein that modulates neurite outgrowth of PC12 cells.
Oguchi ME, Noguchi K, Fukuda M
PloS one 2017;12(4):e0174883
PloS one 2017;12(4):e0174883
Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
Huang M, Cheng G, Tan H, Qin R, Zou Y, Wang Y, Zhang Y
Experimental neurology 2017 Sep;295:66-76
Experimental neurology 2017 Sep;295:66-76
Effects of epigallocatechin‑3‑gallate on iron metabolism in spinal cord motor neurons.
Che F, Wang G, Yu J, Wang X, Lu Y, Fu Q, Su Q, Jiang J, Du Y
Molecular medicine reports 2017 Sep;16(3):3010-3014
Molecular medicine reports 2017 Sep;16(3):3010-3014
Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains.
Rahbek-Clemmensen T, Lycas MD, Erlendsson S, Eriksen J, Apuschkin M, Vilhardt F, Jørgensen TN, Hansen FH, Gether U
Nature communications 2017 Sep 29;8(1):740
Nature communications 2017 Sep 29;8(1):740
The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor.
Roux BT, Bauer CC, McNeish AJ, Ward SG, Cottrell GS
Scientific reports 2017 Sep 28;7(1):12389
Scientific reports 2017 Sep 28;7(1):12389
The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.
Bermingham DP, Hardaway JA, Refai O, Marks CR, Snider SL, Sturgeon SM, Spencer WC, Colbran RJ, Miller DM 3rd, Blakely RD
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Sep 20;37(38):9288-9304
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Sep 20;37(38):9288-9304
Novel ecto-tagged integrins reveal their trafficking in live cells.
Huet-Calderwood C, Rivera-Molina F, Iwamoto DV, Kromann EB, Toomre D, Calderwood DA
Nature communications 2017 Sep 18;8(1):570
Nature communications 2017 Sep 18;8(1):570
The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning.
Gao J, Marosi M, Choi J, Achiro JM, Kim S, Li S, Otis K, Martin KC, Portera-Cailliau C, Tontonoz P
eLife 2017 Sep 11;6
eLife 2017 Sep 11;6
Salinomycin kills cancer stem cells by sequestering iron in lysosomes.
Mai TT, Hamaï A, Hienzsch A, Cañeque T, Müller S, Wicinski J, Cabaud O, Leroy C, David A, Acevedo V, Ryo A, Ginestier C, Birnbaum D, Charafe-Jauffret E, Codogno P, Mehrpour M, Rodriguez R
Nature chemistry 2017 Oct;9(10):1025-1033
Nature chemistry 2017 Oct;9(10):1025-1033
Renal iron accumulation occurs in lupus nephritis and iron chelation delays the onset of albuminuria.
Marks ES, Bonnemaison ML, Brusnahan SK, Zhang W, Fan W, Garrison JC, Boesen EI
Scientific reports 2017 Oct 9;7(1):12821
Scientific reports 2017 Oct 9;7(1):12821
Iron-responsive element-binding protein 2 plays an essential role in regulating prostate cancer cell growth.
Deng Z, Manz DH, Torti SV, Torti FM
Oncotarget 2017 Oct 10;8(47):82231-82243
Oncotarget 2017 Oct 10;8(47):82231-82243
Role of catalytic iron and oxidative stress in nitrofen-induced congenital diaphragmatic hernia and its amelioration by Saireito (TJ-114).
Hirako S, Tsuda H, Ito F, Okazaki Y, Hirayama T, Nagasawa H, Nakano T, Imai K, Kotani T, Kikkawa F, Toyokuni S
Journal of clinical biochemistry and nutrition 2017 Nov;61(3):176-182
Journal of clinical biochemistry and nutrition 2017 Nov;61(3):176-182
Influenza virus genome reaches the plasma membrane via a modified endoplasmic reticulum and Rab11-dependent vesicles.
de Castro Martin IF, Fournier G, Sachse M, Pizarro-Cerda J, Risco C, Naffakh N
Nature communications 2017 Nov 9;8(1):1396
Nature communications 2017 Nov 9;8(1):1396
The lipid raft-dwelling protein US9 can be manipulated to target APP compartmentalization, APP processing, and neurodegenerative disease pathogenesis.
Brandimarti R, Hill GS, Geiger JD, Meucci O
Scientific reports 2017 Nov 8;7(1):15103
Scientific reports 2017 Nov 8;7(1):15103
F-actin reorganization by V-ATPase inhibition in prostate cancer.
Licon-Munoz Y, Michel V, Fordyce CA, Parra KJ
Biology open 2017 Nov 15;6(11):1734-1744
Biology open 2017 Nov 15;6(11):1734-1744
Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA(B) Receptor Protein Complex.
Wright R, Newey SE, Ilie A, Wefelmeyer W, Raimondo JV, Ginham R, Mcllhinney RAJ, Akerman CJ
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 May 31;37(22):5447-5462
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 May 31;37(22):5447-5462
Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism.
Day PM, Thompson CD, Lowy DR, Schiller JT
Journal of virology 2017 May 15;91(10)
Journal of virology 2017 May 15;91(10)
EBV MicroRNA BART16 Suppresses Type I IFN Signaling.
Hooykaas MJG, van Gent M, Soppe JA, Kruse E, Boer IGJ, van Leenen D, Groot Koerkamp MJA, Holstege FCP, Ressing ME, Wiertz EJHJ, Lebbink RJ
Journal of immunology (Baltimore, Md. : 1950) 2017 May 15;198(10):4062-4073
Journal of immunology (Baltimore, Md. : 1950) 2017 May 15;198(10):4062-4073
Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia.
Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Günther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E
The Journal of cell biology 2017 May 1;216(5):1337-1355
The Journal of cell biology 2017 May 1;216(5):1337-1355
Sphingomyelins and ceramides with VLCPUFAs are excluded from low-density raft-like domains in differentiating spermatogenic cells.
Santiago Valtierra FX, Mateos MV, Aveldaño MI, Oresti GM
Journal of lipid research 2017 Mar;58(3):529-542
Journal of lipid research 2017 Mar;58(3):529-542
DCYTB is a predictor of outcome in breast cancer that functions via iron-independent mechanisms.
Lemler DJ, Lynch ML, Tesfay L, Deng Z, Paul BT, Wang X, Hegde P, Manz DH, Torti SV, Torti FM
Breast cancer research : BCR 2017 Mar 7;19(1):25
Breast cancer research : BCR 2017 Mar 7;19(1):25
Adenovirus Modulates Toll-Like Receptor 4 Signaling by Reprogramming ORP1L-VAP Protein Contacts for Cholesterol Transport from Endosomes to the Endoplasmic Reticulum.
Cianciola NL, Chung S, Manor D, Carlin CR
Journal of virology 2017 Mar 15;91(6)
Journal of virology 2017 Mar 15;91(6)
Na(+)/H(+) Exchanger 9 Regulates Iron Mobilization at the Blood-Brain Barrier in Response to Iron Starvation.
Beydoun R, Hamood MA, Gomez Zubieta DM, Kondapalli KC
The Journal of biological chemistry 2017 Mar 10;292(10):4293-4301
The Journal of biological chemistry 2017 Mar 10;292(10):4293-4301
Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.
Radzicki D, Pollema-Mays SL, Sanz-Clemente A, Martina M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 1;37(9):2292-2304
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Mar 1;37(9):2292-2304
BRAF mutations are associated with increased iron regulatory protein-2 expression in colorectal tumorigenesis.
Horniblow RD, Bedford M, Hollingworth R, Evans S, Sutton E, Lal N, Beggs A, Iqbal TH, Tselepis C
Cancer science 2017 Jun;108(6):1135-1143
Cancer science 2017 Jun;108(6):1135-1143
Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.
Dietrich P, Johnson IM, Alli S, Dragatsis I
PLoS genetics 2017 Jul;13(7):e1006846
PLoS genetics 2017 Jul;13(7):e1006846
Iron addiction: a novel therapeutic target in ovarian cancer.
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, Xian W, McKeon F, Lynch M, Crum CP, Hegde P, Brewer M, Wang X, Miller LD, Dyment N, Torti FM, Torti SV
Oncogene 2017 Jul 20;36(29):4089-4099
Oncogene 2017 Jul 20;36(29):4089-4099
Tumor-initiating cells of breast and prostate origin show alterations in the expression of genes related to iron metabolism.
Rychtarcikova Z, Lettlova S, Tomkova V, Korenkova V, Langerova L, Simonova E, Zjablovskaja P, Alberich-Jorda M, Neuzil J, Truksa J
Oncotarget 2017 Jan 24;8(4):6376-6398
Oncotarget 2017 Jan 24;8(4):6376-6398
Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes.
Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF
Science signaling 2017 Jan 24;10(463)
Science signaling 2017 Jan 24;10(463)
Matriptase-mediated cleavage of EpCAM destabilizes claudins and dysregulates intestinal epithelial homeostasis.
Wu CJ, Feng X, Lu M, Morimura S, Udey MC
The Journal of clinical investigation 2017 Feb 1;127(2):623-634
The Journal of clinical investigation 2017 Feb 1;127(2):623-634
Characterization of a KCNB1 variant associated with autism, intellectual disability, and epilepsy.
Calhoun JD, Vanoye CG, Kok F, George AL Jr, Kearney JA
Neurology. Genetics 2017 Dec;3(6):e198
Neurology. Genetics 2017 Dec;3(6):e198
Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells.
Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen JB, Alpini G, Glaser S, Alvaro D, Invernizzi P, Cairo G, Recalcati S
Scientific reports 2017 Dec 15;7(1):17667
Scientific reports 2017 Dec 15;7(1):17667
Identification and dynamics of the human ZDHHC16-ZDHHC6 palmitoylation cascade.
Abrami L, Dallavilla T, Sandoz PA, Demir M, Kunz B, Savoglidis G, Hatzimanikatis V, van der Goot FG
eLife 2017 Aug 15;6
eLife 2017 Aug 15;6
Essential and selective role of SNX12 in transport of endocytic and retrograde cargo.
Priya A, Sugatha J, Parveen S, Lacas-Gervais S, Raj P, Gilleron J, Datta S
Journal of cell science 2017 Aug 15;130(16):2707-2721
Journal of cell science 2017 Aug 15;130(16):2707-2721
SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
Xu J, Zhang L, Ye Y, Shan Y, Wan C, Wang J, Pei D, Shu X, Liu J
Structure (London, England : 1993) 2017 Aug 1;25(8):1251-1263.e5
Structure (London, England : 1993) 2017 Aug 1;25(8):1251-1263.e5
The role of microsporidian polar tube protein 4 (PTP4) in host cell infection.
Han B, Polonais V, Sugi T, Yakubu R, Takvorian PM, Cali A, Maier K, Long M, Levy M, Tanowitz HB, Pan G, Delbac F, Zhou Z, Weiss LM
PLoS pathogens 2017 Apr;13(4):e1006341
PLoS pathogens 2017 Apr;13(4):e1006341
mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery.
Dauner K, Eid W, Raghupathy R, Presley JF, Zha X
The Journal of biological chemistry 2017 Apr 7;292(14):5737-5747
The Journal of biological chemistry 2017 Apr 7;292(14):5737-5747
Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.
Grieve AG, Xu H, Künzel U, Bambrough P, Sieber B, Freeman M
eLife 2017 Apr 22;6
eLife 2017 Apr 22;6
FBXL5 Inactivation in Mouse Brain Induces Aberrant Proliferation of Neural Stem Progenitor Cells.
Yamauchi T, Nishiyama M, Moroishi T, Kawamura A, Nakayama KI
Molecular and cellular biology 2017 Apr 15;37(8)
Molecular and cellular biology 2017 Apr 15;37(8)
A kainate receptor subunit promotes the recycling of the neuron-specific K(+)-Cl(-) co-transporter KCC2 in hippocampal neurons.
Pressey JC, Mahadevan V, Khademullah CS, Dargaei Z, Chevrier J, Ye W, Huang M, Chauhan AK, Meas SJ, Uvarov P, Airaksinen MS, Woodin MA
The Journal of biological chemistry 2017 Apr 14;292(15):6190-6201
The Journal of biological chemistry 2017 Apr 14;292(15):6190-6201
A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.
Bruurs LJM, Zwakenberg S, van der Net MC, Zwartkruis FJ, Bos JL
Molecular and cellular biology 2017 Apr 1;37(7)
Molecular and cellular biology 2017 Apr 1;37(7)
The Role of BCA2 in the Endocytic Trafficking of EGFR and Significance as a Prognostic Biomarker in Cancer.
Wymant JM, Hiscox S, Westwell AD, Urbé S, Clague MJ, Jones AT
Journal of Cancer 2016;7(15):2388-2407
Journal of Cancer 2016;7(15):2388-2407
Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation.
Asperti M, Stuemler T, Poli M, Gryzik M, Lifshitz L, Meyron-Holtz EG, Vlodavsky I, Arosio P
PloS one 2016;11(10):e0164183
PloS one 2016;11(10):e0164183
Establishing and characterizing a new primary effusion lymphoma cell line harboring Kaposi's sarcoma-associated herpesvirus.
Osawa M, Mine S, Ota S, Kato K, Sekizuka T, Kuroda M, Kataoka M, Fukumoto H, Sato Y, Kanno T, Hasegawa H, Ueda K, Fukayama M, Maeda T, Kanoh S, Kawana A, Fujikura Y, Katano H
Infectious agents and cancer 2016;11:37
Infectious agents and cancer 2016;11:37
In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.
Gasperini L, Meneghetti E, Legname G, Benetti F
Frontiers in neuroscience 2016;10:437
Frontiers in neuroscience 2016;10:437
Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers.
Hersom M, Helms HC, Pretzer N, Goldeman C, Jensen AI, Severin G, Nielsen MS, Holm R, Brodin B
Molecular and cellular neurosciences 2016 Oct;76:59-67
Molecular and cellular neurosciences 2016 Oct;76:59-67
Iron, microbiota and colorectal cancer.
Ng O
Wiener medizinische Wochenschrift (1946) 2016 Oct;166(13-14):431-436
Wiener medizinische Wochenschrift (1946) 2016 Oct;166(13-14):431-436
Real-time 3D stabilization of a super-resolution microscope using an electrically tunable lens.
Tafteh R, Abraham L, Seo D, Lu HY, Gold MR, Chou KC
Optics express 2016 Oct 3;24(20):22959-22970
Optics express 2016 Oct 3;24(20):22959-22970
Ubiquitin-dependent folding of the Wnt signaling coreceptor LRP6.
Perrody E, Abrami L, Feldman M, Kunz B, Urbé S, van der Goot FG
eLife 2016 Oct 18;5
eLife 2016 Oct 18;5
Atg9A trafficking through the recycling endosomes is required for autophagosome formation.
Imai K, Hao F, Fujita N, Tsuji Y, Oe Y, Araki Y, Hamasaki M, Noda T, Yoshimori T
Journal of cell science 2016 Oct 15;129(20):3781-3791
Journal of cell science 2016 Oct 15;129(20):3781-3791
Aberrant Splicing Promotes Proteasomal Degradation of L-type Ca(V)1.2 Calcium Channels by Competitive Binding for Ca(V)β Subunits in Cardiac Hypertrophy.
Hu Z, Wang JW, Yu D, Soon JL, de Kleijn DP, Foo R, Liao P, Colecraft HM, Soong TW
Scientific reports 2016 Oct 12;6:35247
Scientific reports 2016 Oct 12;6:35247
The polarity protein Scribble positions DLC3 at adherens junctions to regulate Rho signaling.
Hendrick J, Franz-Wachtel M, Moeller Y, Schmid S, Macek B, Olayioye MA
Journal of cell science 2016 Oct 1;129(19):3583-3596
Journal of cell science 2016 Oct 1;129(19):3583-3596
Pentobarbital modifies the lipid raft-protein interaction: A first clue about the anesthesia mechanism on NMDA and GABA(A) receptors.
Sierra-Valdez FJ, Ruiz-Suárez JC, Delint-Ramirez I
Biochimica et biophysica acta 2016 Nov;1858(11):2603-2610
Biochimica et biophysica acta 2016 Nov;1858(11):2603-2610
Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure.
Corcelle-Termeau E, Vindeløv SD, Hämälistö S, Mograbi B, Keldsbo A, Bräsen JH, Favaro E, Adam D, Szyniarowski P, Hofman P, Krautwald S, Farkas T, Petersen NH, Rohde M, Linkermann A, Jäättelä M
Autophagy 2016 May 3;12(5):833-49
Autophagy 2016 May 3;12(5):833-49
Nucleus Accumbens AMPA Receptors Are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats.
Russell SE, Puttick DJ, Sawyer AM, Potter DN, Mague S, Carlezon WA Jr, Chartoff EH
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 May 25;36(21):5748-62
The Journal of neuroscience : the official journal of the Society for Neuroscience 2016 May 25;36(21):5748-62
Cytoplasmic cyclin D1 regulates cell invasion and metastasis through the phosphorylation of paxillin.
Fusté NP, Fernández-Hernández R, Cemeli T, Mirantes C, Pedraza N, Rafel M, Torres-Rosell J, Colomina N, Ferrezuelo F, Dolcet X, Garí E
Nature communications 2016 May 16;7:11581
Nature communications 2016 May 16;7:11581
Using Quantitative Seroproteomics to Identify Antibody Biomarkers in Pancreatic Cancer.
Jhaveri DT, Kim MS, Thompson ED, Huang L, Sharma R, Klein AP, Zheng L, Le DT, Laheru DA, Pandey A, Jaffee EM, Anders RA
Cancer immunology research 2016 Mar;4(3):225-33
Cancer immunology research 2016 Mar;4(3):225-33
Functional characterization of retromer in GLUT4 storage vesicle formation and adipocyte differentiation.
Yang Z, Hong LK, Follett J, Wabitsch M, Hamilton NA, Collins BM, Bugarcic A, Teasdale RD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Mar;30(3):1037-50
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016 Mar;30(3):1037-50
Differential Targeting of SLC30A10/ZnT10 Heterodimers to Endolysosomal Compartments Modulates EGF-Induced MEK/ERK1/2 Activity.
Zhao Y, Feresin RG, Falcon-Perez JM, Salazar G
Traffic (Copenhagen, Denmark) 2016 Mar;17(3):267-88
Traffic (Copenhagen, Denmark) 2016 Mar;17(3):267-88
The potential of deferasirox as a novel therapeutic modality in gastric cancer.
Choi JH, Kim JS, Won YW, Uhm J, Park BB, Lee YY
World journal of surgical oncology 2016 Mar 10;14:77
World journal of surgical oncology 2016 Mar 10;14:77
Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice.
Guo C, Hao LJ, Yang ZH, Chai R, Zhang S, Gu Y, Gao HL, Zhong ML, Wang T, Li JY, Wang ZY
Experimental neurology 2016 Jun;280:13-23
Experimental neurology 2016 Jun;280:13-23
Prenatal Alcohol Exposure Alters Fetal Iron Distribution and Elevates Hepatic Hepcidin in a Rat Model of Fetal Alcohol Spectrum Disorders.
Huebner SM, Blohowiak SE, Kling PJ, Smith SM
The Journal of nutrition 2016 Jun;146(6):1180-8
The Journal of nutrition 2016 Jun;146(6):1180-8
Transferrin receptor facilitates TGF-β and BMP signaling activation to control craniofacial morphogenesis.
Lei R, Zhang K, Liu K, Shao X, Ding Z, Wang F, Hong Y, Zhu M, Li H, Li H
Cell death & disease 2016 Jun 30;7(6):e2282
Cell death & disease 2016 Jun 30;7(6):e2282
SEPT8 modulates β-amyloidogenic processing of APP by affecting the sorting and accumulation of BACE1.
Kurkinen KM, Marttinen M, Turner L, Natunen T, Mäkinen P, Haapalinna F, Sarajärvi T, Gabbouj S, Kurki M, Paananen J, Koivisto AM, Rauramaa T, Leinonen V, Tanila H, Soininen H, Lucas FR, Haapasalo A, Hiltunen M
Journal of cell science 2016 Jun 1;129(11):2224-38
Journal of cell science 2016 Jun 1;129(11):2224-38
Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice.
Xue H, Chen D, Zhong YK, Zhou ZD, Fang SX, Li MY, Guo C
Annals of the New York Academy of Sciences 2016 Jul;1375(1):52-65
Annals of the New York Academy of Sciences 2016 Jul;1375(1):52-65
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain supports Frizzled 7 trafficking and signalling.
Egea-Jimenez AL, Gallardo R, Garcia-Pino A, Ivarsson Y, Wawrzyniak AM, Kashyap R, Loris R, Schymkowitz J, Rousseau F, Zimmermann P
Nature communications 2016 Jul 8;7:12101
Nature communications 2016 Jul 8;7:12101
Proteomic analysis of native cerebellar iFGF14 complexes.
Bosch MK, Nerbonne JM, Townsend RR, Miyazaki H, Nukina N, Ornitz DM, Marionneau C
Channels (Austin, Tex.) 2016 Jul 3;10(4):297-312
Channels (Austin, Tex.) 2016 Jul 3;10(4):297-312
CKAP4 is a Dickkopf1 receptor and is involved in tumor progression.
Kimura H, Fumoto K, Shojima K, Nojima S, Osugi Y, Tomihara H, Eguchi H, Shintani Y, Endo H, Inoue M, Doki Y, Okumura M, Morii E, Kikuchi A
The Journal of clinical investigation 2016 Jul 1;126(7):2689-705
The Journal of clinical investigation 2016 Jul 1;126(7):2689-705
Relationship between ubiquilin-1 and BACE1 in human Alzheimer's disease and APdE9 transgenic mouse brain and cell-based models.
Natunen T, Takalo M, Kemppainen S, Leskelä S, Marttinen M, Kurkinen KMA, Pursiheimo JP, Sarajärvi T, Viswanathan J, Gabbouj S, Solje E, Tahvanainen E, Pirttimäki T, Kurki M, Paananen J, Rauramaa T, Miettinen P, Mäkinen P, Leinonen V, Soininen H, Airenne K, Tanzi RE, Tanila H, Haapasalo A, Hiltunen M
Neurobiology of disease 2016 Jan;85:187-205
Neurobiology of disease 2016 Jan;85:187-205
A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency.
Jabara HH, Boyden SE, Chou J, Ramesh N, Massaad MJ, Benson H, Bainter W, Fraulino D, Rahimov F, Sieff C, Liu ZJ, Alshemmari SH, Al-Ramadi BK, Al-Dhekri H, Arnaout R, Abu-Shukair M, Vatsayan A, Silver E, Ahuja S, Davies EG, Sola-Visner M, Ohsumi TK, Andrews NC, Notarangelo LD, Fleming MD, Al-Herz W, Kunkel LM, Geha RS
Nature genetics 2016 Jan;48(1):74-8
Nature genetics 2016 Jan;48(1):74-8
A phosphoinositide conversion mechanism for exit from endosomes.
Ketel K, Krauss M, Nicot AS, Puchkov D, Wieffer M, Müller R, Subramanian D, Schultz C, Laporte J, Haucke V
Nature 2016 Jan 21;529(7586):408-12
Nature 2016 Jan 21;529(7586):408-12
Antigen Export Reduces Antigen Presentation and Limits T Cell Control of M. tuberculosis.
Srivastava S, Grace PS, Ernst JD
Cell host & microbe 2016 Jan 13;19(1):44-54
Cell host & microbe 2016 Jan 13;19(1):44-54
OCRL1 engages with the F-BAR protein pacsin 2 to promote biogenesis of membrane-trafficking intermediates.
Billcliff PG, Noakes CJ, Mehta ZB, Yan G, Mak L, Woscholski R, Lowe M
Molecular biology of the cell 2016 Jan 1;27(1):90-107
Molecular biology of the cell 2016 Jan 1;27(1):90-107
Deubiquitylase Inhibition Reveals Liver X Receptor-independent Transcriptional Regulation of the E3 Ubiquitin Ligase IDOL and Lipoprotein Uptake.
Nelson JK, Cook EC, Loregger A, Hoeksema MA, Scheij S, Kovacevic I, Hordijk PL, Ovaa H, Zelcer N
The Journal of biological chemistry 2016 Feb 26;291(9):4813-25
The Journal of biological chemistry 2016 Feb 26;291(9):4813-25
Endosomal Na+/H+ exchanger NHE5 influences MET recycling and cell migration.
Fan SH, Numata Y, Numata M
Molecular biology of the cell 2016 Feb 15;27(4):702-15
Molecular biology of the cell 2016 Feb 15;27(4):702-15
Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.
Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ
The Journal of cell biology 2016 Feb 1;212(3):349-64
The Journal of cell biology 2016 Feb 1;212(3):349-64
Hephaestin and ceruloplasmin facilitate iron metabolism in the mouse kidney.
Jiang B, Liu G, Zheng J, Chen M, Maimaitiming Z, Chen M, Liu S, Jiang R, Fuqua BK, Dunaief JL, Vulpe CD, Anderson GJ, Wang H, Chen H
Scientific reports 2016 Dec 19;6:39470
Scientific reports 2016 Dec 19;6:39470
The phospholipid flippase ATP9A is required for the recycling pathway from the endosomes to the plasma membrane.
Tanaka Y, Ono N, Shima T, Tanaka G, Katoh Y, Nakayama K, Takatsu H, Shin HW
Molecular biology of the cell 2016 Dec 1;27(24):3883-3893
Molecular biology of the cell 2016 Dec 1;27(24):3883-3893
Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease.
Baksi S, Tripathi AK, Singh N
Free radical biology & medicine 2016 Aug;97:292-306
Free radical biology & medicine 2016 Aug;97:292-306
Loss of NCB5OR in the cerebellum disturbs iron pathways, potentiates behavioral abnormalities, and exacerbates harmaline-induced tremor in mice.
Stroh MA, Winter MK, Swerdlow RH, McCarson KE, Zhu H
Metabolic brain disease 2016 Aug;31(4):951-64
Metabolic brain disease 2016 Aug;31(4):951-64
A dominant TRPV4 variant underlies osteochondrodysplasia in Scottish fold cats.
Gandolfi B, Alamri S, Darby WG, Adhikari B, Lattimer JC, Malik R, Wade CM, Lyons LA, Cheng J, Bateman JF, McIntyre P, Lamandé SR, Haase B
Osteoarthritis and cartilage 2016 Aug;24(8):1441-50
Osteoarthritis and cartilage 2016 Aug;24(8):1441-50
Lrp4 in astrocytes modulates glutamatergic transmission.
Sun XD, Li L, Liu F, Huang ZH, Bean JC, Jiao HF, Barik A, Kim SM, Wu H, Shen C, Tian Y, Lin TW, Bates R, Sathyamurthy A, Chen YJ, Yin DM, Xiong L, Lin HP, Hu JX, Li BM, Gao TM, Xiong WC, Mei L
Nature neuroscience 2016 Aug;19(8):1010-8
Nature neuroscience 2016 Aug;19(8):1010-8
Contrasting intra- and extracellular distribution of catalytic ferrous iron in ovalbumin-induced peritonitis.
Ito F, Nishiyama T, Shi L, Mori M, Hirayama T, Nagasawa H, Yasui H, Toyokuni S
Biochemical and biophysical research communications 2016 Aug 5;476(4):600-606
Biochemical and biophysical research communications 2016 Aug 5;476(4):600-606
The transcription factor calcium-response factor limits NMDA receptor-dependent transcription in the developing brain.
Lyons MR, Chen LF, Deng JV, Finn C, Pfenning AR, Sabhlok A, Wilson KM, West AE
Journal of neurochemistry 2016 Apr;137(2):164-76
Journal of neurochemistry 2016 Apr;137(2):164-76
African Swine Fever Virus Undergoes Outer Envelope Disruption, Capsid Disassembly and Inner Envelope Fusion before Core Release from Multivesicular Endosomes.
Hernáez B, Guerra M, Salas ML, Andrés G
PLoS pathogens 2016 Apr;12(4):e1005595
PLoS pathogens 2016 Apr;12(4):e1005595
Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy.
Shi Y, Tan SH, Ng S, Zhou J, Yang ND, Koo GB, McMahon KA, Parton RG, Hill MM, Del Pozo MA, Kim YS, Shen HM
Autophagy 2015;11(5):769-84
Autophagy 2015;11(5):769-84
Ultrastructural relationship of the phagophore with surrounding organelles.
Biazik J, Ylä-Anttila P, Vihinen H, Jokitalo E, Eskelinen EL
Autophagy 2015;11(3):439-51
Autophagy 2015;11(3):439-51
A Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of Optineurin.
Sirohi K, Kumari A, Radha V, Swarup G
PloS one 2015;10(9):e0138289
PloS one 2015;10(9):e0138289
Role for Rab10 in Methamphetamine-Induced Behavior.
Vanderwerf SM, Buck DC, Wilmarth PA, Sears LM, David LL, Morton DB, Neve KA
PloS one 2015;10(8):e0136167
PloS one 2015;10(8):e0136167
Pseudomonas aeruginosa Reduces VX-809 Stimulated F508del-CFTR Chloride Secretion by Airway Epithelial Cells.
Stanton BA, Coutermarsh B, Barnaby R, Hogan D
PloS one 2015;10(5):e0127742
PloS one 2015;10(5):e0127742
Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.
Chen J, Tibroni N, Sauter D, Galaski J, Miura T, Alter G, Mueller B, Haller C, Walker BD, Kirchhoff F, Brumme ZL, Ueno T, Fackler OT
PloS one 2015;10(3):e0120434
PloS one 2015;10(3):e0120434
High fat diet subverts hepatocellular iron uptake determining dysmetabolic iron overload.
Dongiovanni P, Lanti C, Gatti S, Rametta R, Recalcati S, Maggioni M, Fracanzani AL, Riso P, Cairo G, Fargion S, Valenti L
PloS one 2015;10(2):e0116855
PloS one 2015;10(2):e0116855
Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.
Gilad D, Shorer S, Ketzef M, Friedman A, Sekler I, Aizenman E, Hershfinkel M
Neurobiology of disease 2015 Sep;81:4-13
Neurobiology of disease 2015 Sep;81:4-13
ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.
Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL
The Journal of cell biology 2015 Sep 28;210(7):1055-63
The Journal of cell biology 2015 Sep 28;210(7):1055-63
Noncanonical role of transferrin receptor 1 is essential for intestinal homeostasis.
Chen AC, Donovan A, Ned-Sykes R, Andrews NC
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 15;112(37):11714-9
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 15;112(37):11714-9
Novel Role of TRPML2 in the Regulation of the Innate Immune Response.
Sun L, Hua Y, Vergarajauregui S, Diab HI, Puertollano R
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 15;195(10):4922-32
Journal of immunology (Baltimore, Md. : 1950) 2015 Nov 15;195(10):4922-32
Amyloid precursor protein enhances Nav1.6 sodium channel cell surface expression.
Liu C, Tan FC, Xiao ZC, Dawe GS
The Journal of biological chemistry 2015 May 8;290(19):12048-57
The Journal of biological chemistry 2015 May 8;290(19):12048-57
Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast Differentiation.
Dayer C, Stamenkovic I
The Journal of biological chemistry 2015 May 29;290(22):13763-78
The Journal of biological chemistry 2015 May 29;290(22):13763-78
Synaptic activity regulates AMPA receptor trafficking through different recycling pathways.
Zheng N, Jeyifous O, Munro C, Montgomery JM, Green WN
eLife 2015 May 13;4
eLife 2015 May 13;4
Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation.
Shi ZH, Shi FF, Wang YQ, Sheftel AD, Nie G, Zhao YS, You LH, Gou YJ, Duan XL, Zhao BL, Xu HM, Li CY, Chang YZ
Cellular and molecular life sciences : CMLS 2015 Mar;72(5):983-97
Cellular and molecular life sciences : CMLS 2015 Mar;72(5):983-97
LDL-R promoting activity of peptides derived from human PCSK9 catalytic domain (153-421): design, synthesis and biochemical evaluation.
Alghamdi RH, O'Reilly P, Lu C, Gomes J, Lagace TA, Basak A
European journal of medicinal chemistry 2015 Mar 6;92:890-907
European journal of medicinal chemistry 2015 Mar 6;92:890-907
Transport through recycling endosomes requires EHD1 recruitment by a phosphatidylserine translocase.
Lee S, Uchida Y, Wang J, Matsudaira T, Nakagawa T, Kishimoto T, Mukai K, Inaba T, Kobayashi T, Molday RS, Taguchi T, Arai H
The EMBO journal 2015 Mar 4;34(5):669-88
The EMBO journal 2015 Mar 4;34(5):669-88
Lysosomal degradation of CD44 mediates ceramide nanoliposome-induced anoikis and diminished extravasation in metastatic carcinoma cells.
Haakenson JK, Khokhlatchev AV, Choi YJ, Linton SS, Zhang P, Zaki PM, Fu C, Cooper TK, Manni A, Zhu J, Fox TE, Dong C, Kester M
The Journal of biological chemistry 2015 Mar 27;290(13):8632-43
The Journal of biological chemistry 2015 Mar 27;290(13):8632-43
Antibodies to GABAA receptor α1 and γ2 subunits: clinical and serologic characterization.
Pettingill P, Kramer HB, Coebergh JA, Pettingill R, Maxwell S, Nibber A, Malaspina A, Jacob A, Irani SR, Buckley C, Beeson D, Lang B, Waters P, Vincent A
Neurology 2015 Mar 24;84(12):1233-41
Neurology 2015 Mar 24;84(12):1233-41
CD81 promotes both the degradation of transferrin receptor 2 (TfR2) and the Tfr2-mediated maintenance of hepcidin expression.
Chen J, Enns CA
The Journal of biological chemistry 2015 Mar 20;290(12):7841-50
The Journal of biological chemistry 2015 Mar 20;290(12):7841-50
GluN2B-Containing NMDA Receptors Regulate AMPA Receptor Traffic through Anchoring of the Synaptic Proteasome.
Ferreira JS, Schmidt J, Rio P, Águas R, Rooyakkers A, Li KW, Smit AB, Craig AM, Carvalho AL
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jun 3;35(22):8462-79
The Journal of neuroscience : the official journal of the Society for Neuroscience 2015 Jun 3;35(22):8462-79
Essential role of flotillin-1 palmitoylation in the intracellular localization and signaling function of IGF-1 receptor.
Jang D, Kwon H, Jeong K, Lee J, Pak Y
Journal of cell science 2015 Jun 1;128(11):2179-90
Journal of cell science 2015 Jun 1;128(11):2179-90
Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells.
Ruas M, Davis LC, Chen CC, Morgan AJ, Chuang KT, Walseth TF, Grimm C, Garnham C, Powell T, Platt N, Platt FM, Biel M, Wahl-Schott C, Parrington J, Galione A
The EMBO journal 2015 Jul 2;34(13):1743-58
The EMBO journal 2015 Jul 2;34(13):1743-58
LXRs link metabolism to inflammation through Abca1-dependent regulation of membrane composition and TLR signaling.
Ito A, Hong C, Rong X, Zhu X, Tarling EJ, Hedde PN, Gratton E, Parks J, Tontonoz P
eLife 2015 Jul 14;4:e08009
eLife 2015 Jul 14;4:e08009
A novel model for brain iron uptake: introducing the concept of regulation.
Simpson IA, Ponnuru P, Klinger ME, Myers RL, Devraj K, Coe CL, Lubach GR, Carruthers A, Connor JR
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 Jan;35(1):48-57
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2015 Jan;35(1):48-57
Cell surface heparan sulfate proteoglycans control adhesion and invasion of breast carcinoma cells.
Lim HC, Multhaupt HA, Couchman JR
Molecular cancer 2015 Jan 27;14(1):15
Molecular cancer 2015 Jan 27;14(1):15
Hepatic oleate regulates adipose tissue lipogenesis and fatty acid oxidation.
Burhans MS, Flowers MT, Harrington KR, Bond LM, Guo CA, Anderson RM, Ntambi JM
Journal of lipid research 2015 Feb;56(2):304-18
Journal of lipid research 2015 Feb;56(2):304-18
A direct role for ATP1A1 in unconventional secretion of fibroblast growth factor 2.
Zacherl S, La Venuta G, Müller HM, Wegehingel S, Dimou E, Sehr P, Lewis JD, Erfle H, Pepperkok R, Nickel W
The Journal of biological chemistry 2015 Feb 6;290(6):3654-65
The Journal of biological chemistry 2015 Feb 6;290(6):3654-65
Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly.
Gammella E, Diaz V, Recalcati S, Buratti P, Samaja M, Dey S, Noguchi CT, Gassmann M, Cairo G
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Feb 15;308(4):R330-5
American journal of physiology. Regulatory, integrative and comparative physiology 2015 Feb 15;308(4):R330-5
Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.
Robertson J, Jacquemet G, Byron A, Jones MC, Warwood S, Selley JN, Knight D, Humphries JD, Humphries MJ
Nature communications 2015 Feb 13;6:6265
Nature communications 2015 Feb 13;6:6265
Beyond the redox imbalance: Oxidative stress contributes to an impaired GLUT3 modulation in Huntington's disease.
Covarrubias-Pinto A, Moll P, Solís-Maldonado M, Acuña AI, Riveros A, Miró MP, Papic E, Beltrán FA, Cepeda C, Concha II, Brauchi S, Castro MA
Free radical biology & medicine 2015 Dec;89:1085-96
Free radical biology & medicine 2015 Dec;89:1085-96
Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron.
Mori M, Ito F, Shi L, Wang Y, Ishida C, Hattori Y, Niwa M, Hirayama T, Nagasawa H, Iwase A, Kikkawa F, Toyokuni S
Redox biology 2015 Dec;6:578-586
Redox biology 2015 Dec;6:578-586
Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.
Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ
The Journal of cell biology 2015 Dec 21;211(6):1157-76
The Journal of cell biology 2015 Dec 21;211(6):1157-76
A Kinome-Wide Small Interfering RNA Screen Identifies Proviral and Antiviral Host Factors in Severe Acute Respiratory Syndrome Coronavirus Replication, Including Double-Stranded RNA-Activated Protein Kinase and Early Secretory Pathway Proteins.
de Wilde AH, Wannee KF, Scholte FE, Goeman JJ, Ten Dijke P, Snijder EJ, Kikkert M, van Hemert MJ
Journal of virology 2015 Aug;89(16):8318-33
Journal of virology 2015 Aug;89(16):8318-33
Auxiliary KCNE subunits modulate both homotetrameric Kv2.1 and heterotetrameric Kv2.1/Kv6.4 channels.
David JP, Stas JI, Schmitt N, Bocksteins E
Scientific reports 2015 Aug 5;5:12813
Scientific reports 2015 Aug 5;5:12813
MicroRNA-9 induces defective trafficking of Nav1.1 and Nav1.2 by targeting Navβ2 protein coding region in rat with chronic brain hypoperfusion.
Sun LH, Yan ML, Hu XL, Peng LW, Che H, Bao YN, Guo F, Liu T, Chen X, Zhang R, Ban T, Wang N, Liu HL, Hou X, Ai J
Molecular neurodegeneration 2015 Aug 11;10:36
Molecular neurodegeneration 2015 Aug 11;10:36
The mTORC1/4E-BP pathway coordinates hemoglobin production with L-leucine availability.
Chung J, Bauer DE, Ghamari A, Nizzi CP, Deck KM, Kingsley PD, Yien YY, Huston NC, Chen C, Schultz IJ, Dalton AJ, Wittig JG, Palis J, Orkin SH, Lodish HF, Eisenstein RS, Cantor AB, Paw BH
Science signaling 2015 Apr 14;8(372):ra34
Science signaling 2015 Apr 14;8(372):ra34
SDF-1 chemokine signalling modulates the apoptotic responses to iron deprivation of clathrin-depleted DT40 cells.
Pance A, Morrissey-Wettey FR, Craig H, Downing A, Talbot R, Jackson AP
PloS one 2014;9(8):e106278
PloS one 2014;9(8):e106278
α-Taxilin interacts with sorting nexin 4 and participates in the recycling pathway of transferrin receptor.
Sakane H, Horii Y, Nogami S, Kawano Y, Kaneko-Kawano T, Shirataki H
PloS one 2014;9(4):e93509
PloS one 2014;9(4):e93509
Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.
Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T
PloS one 2014;9(2):e89355
PloS one 2014;9(2):e89355
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function.
Müller J, Rana NA, Serth K, Kakuda S, Haltiwanger RS, Gossler A
PloS one 2014;9(2):e88571
PloS one 2014;9(2):e88571
Microtubule-dependent modulation of adhesion complex composition.
Ng DH, Humphries JD, Byron A, Millon-Frémillon A, Humphries MJ
PloS one 2014;9(12):e115213
PloS one 2014;9(12):e115213
Nef neutralizes the ability of exosomes from CD4+ T cells to act as decoys during HIV-1 infection.
de Carvalho JV, de Castro RO, da Silva EZ, Silveira PP, da Silva-Januário ME, Arruda E, Jamur MC, Oliver C, Aguiar RS, daSilva LL
PloS one 2014;9(11):e113691
PloS one 2014;9(11):e113691
The level of HER2 expression is a predictor of antibody-HER2 trafficking behavior in cancer cells.
Ram S, Kim D, Ober RJ, Ward ES
mAbs 2014;6(5):1211-9
mAbs 2014;6(5):1211-9
Methods of analysis of the membrane trafficking pathway from recycling endosomes to lysosomes.
Matsui T, Fukuda M
Methods in enzymology 2014;534:195-206
Methods in enzymology 2014;534:195-206
Sorting nexin 31 binds multiple β integrin cytoplasmic domains and regulates β1 integrin surface levels and stability.
Tseng HY, Thorausch N, Ziegler T, Meves A, Fässler R, Böttcher RT
Journal of molecular biology 2014 Sep 9;426(18):3180-3194
Journal of molecular biology 2014 Sep 9;426(18):3180-3194
De novo KCNB1 mutations in epileptic encephalopathy.
Torkamani A, Bersell K, Jorge BS, Bjork RL Jr, Friedman JR, Bloss CS, Cohen J, Gupta S, Naidu S, Vanoye CG, George AL Jr, Kearney JA
Annals of neurology 2014 Oct;76(4):529-540
Annals of neurology 2014 Oct;76(4):529-540
CUB domain containing protein 1 (CDCP1) modulates adhesion and motility in colon cancer cells.
Orchard-Webb DJ, Lee TC, Cook GP, Blair GE
BMC cancer 2014 Oct 9;14:754
BMC cancer 2014 Oct 9;14:754
Duodenal absorption and tissue utilization of dietary heme and nonheme iron differ in rats.
Cao C, Thomas CE, Insogna KL, O'Brien KO
The Journal of nutrition 2014 Nov;144(11):1710-7
The Journal of nutrition 2014 Nov;144(11):1710-7
TBC1D9B functions as a GTPase-activating protein for Rab11a in polarized MDCK cells.
Gallo LI, Liao Y, Ruiz WG, Clayton DR, Li M, Liu YJ, Jiang Y, Fukuda M, Apodaca G, Yin XM
Molecular biology of the cell 2014 Nov 15;25(23):3779-97
Molecular biology of the cell 2014 Nov 15;25(23):3779-97
Identification of molecular heterogeneity in SNX27-retromer-mediated endosome-to-plasma-membrane recycling.
McGough IJ, Steinberg F, Gallon M, Yatsu A, Ohbayashi N, Heesom KJ, Fukuda M, Cullen PJ
Journal of cell science 2014 Nov 15;127(Pt 22):4940-53
Journal of cell science 2014 Nov 15;127(Pt 22):4940-53
Genetic interaction implicates iRhom2 in the regulation of EGF receptor signalling in mice.
Siggs OM, Grieve A, Xu H, Bambrough P, Christova Y, Freeman M
Biology open 2014 Nov 13;3(12):1151-7
Biology open 2014 Nov 13;3(12):1151-7
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia.
Perdomini M, Belbellaa B, Monassier L, Reutenauer L, Messaddeq N, Cartier N, Crystal RG, Aubourg P, Puccio H
Nature medicine 2014 May;20(5):542-7
Nature medicine 2014 May;20(5):542-7
Localization and proteomic characterization of cholesterol-rich membrane microdomains in the inner ear.
Thomas PV, Cheng AL, Colby CC, Liu L, Patel CK, Josephs L, Duncan RK
Journal of proteomics 2014 May 30;103:178-93
Journal of proteomics 2014 May 30;103:178-93
Differential roles of ubiquitination in the degradation mechanism of cell surface-resident bile salt export pump and multidrug resistance-associated protein 2.
Aida K, Hayashi H, Inamura K, Mizuno T, Sugiyama Y
Molecular pharmacology 2014 Mar;85(3):482-91
Molecular pharmacology 2014 Mar;85(3):482-91
DropArray™, a wall-less 96-well plate for uptake and immunofluorescence microscopy, confirms CD22 recycles.
Ingle GS, Scales SJ
Traffic (Copenhagen, Denmark) 2014 Mar;15(3):255-72
Traffic (Copenhagen, Denmark) 2014 Mar;15(3):255-72
Galectin-3 drives glycosphingolipid-dependent biogenesis of clathrin-independent carriers.
Lakshminarayan R, Wunder C, Becken U, Howes MT, Benzing C, Arumugam S, Sales S, Ariotti N, Chambon V, Lamaze C, Loew D, Shevchenko A, Gaus K, Parton RG, Johannes L
Nature cell biology 2014 Jun;16(6):595-606
Nature cell biology 2014 Jun;16(6):595-606
HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.
Moroishi T, Yamauchi T, Nishiyama M, Nakayama KI
The Journal of biological chemistry 2014 Jun 6;289(23):16430-41
The Journal of biological chemistry 2014 Jun 6;289(23):16430-41
The lipid raft-bound alkaline phosphatase activity increases and the level of transcripts remains unaffected in liver of merosin-deficient LAMA2dy mouse.
Montenegro MF, Moral-Naranjo MT, Campoy FJ, Muñoz-Delgado E, Vidal CJ
Chemico-biological interactions 2014 Jun 5;216:1-8
Chemico-biological interactions 2014 Jun 5;216:1-8
Regulation of Rac1 translocation and activation by membrane domains and their boundaries.
Moissoglu K, Kiessling V, Wan C, Hoffman BD, Norambuena A, Tamm LK, Schwartz MA
Journal of cell science 2014 Jun 1;127(Pt 11):2565-76
Journal of cell science 2014 Jun 1;127(Pt 11):2565-76
Proteomics-Based Identification of Differentially Abundant Proteins from Human Keratinocytes Exposed to Arsenic Trioxide.
Udensi UK, Tackett AJ, Byrum S, Avaritt NL, Sengupta D, Moreland LW, Tchounwou PB, Isokpehi RD
Journal of proteomics & bioinformatics 2014 Jul;7(7):166-178
Journal of proteomics & bioinformatics 2014 Jul;7(7):166-178
A novel posttranscriptional mechanism for dietary cholesterol-mediated suppression of liver LDL receptor expression.
Singh AB, Kan CF, Shende V, Dong B, Liu J
Journal of lipid research 2014 Jul;55(7):1397-407
Journal of lipid research 2014 Jul;55(7):1397-407
Phagolysosomal Trafficking Assay.
Mehra A
Bio-protocol 2014 Jul 5;4(13)
Bio-protocol 2014 Jul 5;4(13)
The epigenetic drug 5-azacytidine interferes with cholesterol and lipid metabolism.
Poirier S, Samami S, Mamarbachi M, Demers A, Chang TY, Vance DE, Hatch GM, Mayer G
The Journal of biological chemistry 2014 Jul 4;289(27):18736-51
The Journal of biological chemistry 2014 Jul 4;289(27):18736-51
Retromer binding to FAM21 and the WASH complex is perturbed by the Parkinson disease-linked VPS35(D620N) mutation.
McGough IJ, Steinberg F, Jia D, Barbuti PA, McMillan KJ, Heesom KJ, Whone AL, Caldwell MA, Billadeau DD, Rosen MK, Cullen PJ
Current biology : CB 2014 Jul 21;24(14):1670-1676
Current biology : CB 2014 Jul 21;24(14):1670-1676
Altered expression of iron regulatory proteins with aging is associated with transient hepatic iron accumulation after environmental heat stress.
Bloomer SA, Han O, Kregel KC, Brown KE
Blood cells, molecules & diseases 2014 Jan;52(1):19-26
Blood cells, molecules & diseases 2014 Jan;52(1):19-26
A functional interplay between the small GTPase Rab11a and mitochondria-shaping proteins regulates mitochondrial positioning and polarization of the actin cytoskeleton downstream of Src family kinases.
Landry MC, Champagne C, Boulanger MC, Jetté A, Fuchs M, Dziengelewski C, Lavoie JN
The Journal of biological chemistry 2014 Jan 24;289(4):2230-49
The Journal of biological chemistry 2014 Jan 24;289(4):2230-49
Masked selection: a straightforward and flexible approach for the selection of binders against specific epitopes and differentially expressed proteins by phage display.
Even-Desrumeaux K, Nevoltris D, Lavaut MN, Alim K, Borg JP, Audebert S, Kerfelec B, Baty D, Chames P
Molecular & cellular proteomics : MCP 2014 Feb;13(2):653-65
Molecular & cellular proteomics : MCP 2014 Feb;13(2):653-65
Arf4 is required for Mammalian development but dispensable for ciliary assembly.
Follit JA, San Agustin JT, Jonassen JA, Huang T, Rivera-Perez JA, Tremblay KD, Pazour GJ
PLoS genetics 2014 Feb;10(2):e1004170
PLoS genetics 2014 Feb;10(2):e1004170
Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.
van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME
PLoS pathogens 2014 Feb;10(2):e1003960
PLoS pathogens 2014 Feb;10(2):e1003960
Transferrin receptor (TfR) trafficking determines brain uptake of TfR antibody affinity variants.
Bien-Ly N, Yu YJ, Bumbaca D, Elstrott J, Boswell CA, Zhang Y, Luk W, Lu Y, Dennis MS, Weimer RM, Chung I, Watts RJ
The Journal of experimental medicine 2014 Feb 10;211(2):233-44
The Journal of experimental medicine 2014 Feb 10;211(2):233-44
Impaired renal function and development in Belgrade rats.
Veuthey T, Hoffmann D, Vaidya VS, Wessling-Resnick M
American journal of physiology. Renal physiology 2014 Feb 1;306(3):F333-43
American journal of physiology. Renal physiology 2014 Feb 1;306(3):F333-43
Disruption of dopamine D1 receptor phosphorylation at serine 421 attenuates cocaine-induced behaviors in mice.
Zhang Y, Wang N, Su P, Lu J, Wang Y
Neuroscience bulletin 2014 Dec;30(6):1025-1035
Neuroscience bulletin 2014 Dec;30(6):1025-1035
Negative feedback at kinetochores underlies a responsive spindle checkpoint signal.
Nijenhuis W, Vallardi G, Teixeira A, Kops GJ, Saurin AT
Nature cell biology 2014 Dec;16(12):1257-64
Nature cell biology 2014 Dec;16(12):1257-64
Stable cell surface expression of GPI-anchored proteins, but not intracellular transport, depends on their fatty acid structure.
Jaensch N, Corrêa IR Jr, Watanabe R
Traffic (Copenhagen, Denmark) 2014 Dec;15(12):1305-29
Traffic (Copenhagen, Denmark) 2014 Dec;15(12):1305-29
Iron increases APP translation and amyloid-beta production in the retina.
Guo LY, Alekseev O, Li Y, Song Y, Dunaief JL
Experimental eye research 2014 Dec;129:31-7
Experimental eye research 2014 Dec;129:31-7
Cell surface marker profiling of human tracheal basal cells reveals distinct subpopulations, identifies MST1/MSP as a mitogenic signal, and identifies new biomarkers for lung squamous cell carcinomas.
Van de Laar E, Clifford M, Hasenoeder S, Kim BR, Wang D, Lee S, Paterson J, Vu NM, Waddell TK, Keshavjee S, Tsao MS, Ailles L, Moghal N
Respiratory research 2014 Dec 31;15(1):160
Respiratory research 2014 Dec 31;15(1):160
aPKCλ maintains the integrity of the glomerular slit diaphragm through trafficking of nephrin to the cell surface.
Satoh D, Hirose T, Harita Y, Daimon C, Harada T, Kurihara H, Yamashita A, Ohno S
Journal of biochemistry 2014 Aug;156(2):115-28
Journal of biochemistry 2014 Aug;156(2):115-28
Cowpox virus protein CPXV012 eludes CTLs by blocking ATP binding to TAP.
Luteijn RD, Hoelen H, Kruse E, van Leeuwen WF, Grootens J, Horst D, Koorengevel M, Drijfhout JW, Kremmer E, Früh K, Neefjes JJ, Killian A, Lebbink RJ, Ressing ME, Wiertz EJ
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 15;193(4):1578-89
Journal of immunology (Baltimore, Md. : 1950) 2014 Aug 15;193(4):1578-89
Protein kinase D1-dependent phosphorylation of dopamine D1 receptor regulates cocaine-induced behavioral responses.
Wang N, Su P, Zhang Y, Lu J, Xing B, Kang K, Li W, Wang Y
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014 Apr;39(5):1290-301
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2014 Apr;39(5):1290-301
The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo.
Schneppenheim J, Hüttl S, Mentrup T, Lüllmann-Rauch R, Rothaug M, Engelke M, Dittmann K, Dressel R, Araki M, Araki K, Wienands J, Fluhrer R, Saftig P, Schröder B
Molecular and cellular biology 2014 Apr;34(8):1398-411
Molecular and cellular biology 2014 Apr;34(8):1398-411
Glutathione-conjugated sulfanylalkanols are substrates for ABCC11 and γ-glutamyl transferase 1: a potential new pathway for the formation of odorant precursors in the apocrine sweat gland.
Baumann T, Bergmann S, Schmidt-Rose T, Max H, Martin A, Enthaler B, Terstegen L, Schweiger D, Kalbacher H, Wenck H, Jedlitschky G, Jovanovic Z
Experimental dermatology 2014 Apr;23(4):247-52
Experimental dermatology 2014 Apr;23(4):247-52
Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis.
DeBosch BJ, Chen Z, Saben JL, Finck BN, Moley KH
The Journal of biological chemistry 2014 Apr 18;289(16):10989-10998
The Journal of biological chemistry 2014 Apr 18;289(16):10989-10998
Prion protein accumulation in lipid rafts of mouse aging brain.
Agostini F, Dotti CG, Pérez-Cañamás A, Ledesma MD, Benetti F, Legname G
PloS one 2013;8(9):e74244
PloS one 2013;8(9):e74244
Ferristatin II promotes degradation of transferrin receptor-1 in vitro and in vivo.
Byrne SL, Buckett PD, Kim J, Luo F, Sanford J, Chen J, Enns C, Wessling-Resnick M
PloS one 2013;8(7):e70199
PloS one 2013;8(7):e70199
Hierarchical organization of multi-site phosphorylation at the CXCR4 C terminus.
Mueller W, Schütz D, Nagel F, Schulz S, Stumm R
PloS one 2013;8(5):e64975
PloS one 2013;8(5):e64975
Expression of the RNA helicase DDX3 and the hypoxia response in breast cancer.
Bol GM, Raman V, van der Groep P, Vermeulen JF, Patel AH, van der Wall E, van Diest PJ
PloS one 2013;8(5):e63548
PloS one 2013;8(5):e63548
Prolonged high fat diet reduces dopamine reuptake without altering DAT gene expression.
Cone JJ, Chartoff EH, Potter DN, Ebner SR, Roitman MF
PloS one 2013;8(3):e58251
PloS one 2013;8(3):e58251
Integrin-mediated signaling induced by simian virus 40 leads to transient uncoupling of cortical actin and the plasma membrane.
Stergiou L, Bauer M, Mair W, Bausch-Fluck D, Drayman N, Wollscheid B, Oppenheim A, Pelkmans L
PloS one 2013;8(2):e55799
PloS one 2013;8(2):e55799
Integrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infection.
Kota KP, Eaton B, Lane D, Ulrich M, Ulrich R, Peyser BD, Robinson CG, Jaissle JG, Pegoraro G, Bavari S, Panchal RG
PloS one 2013;8(1):e55167
PloS one 2013;8(1):e55167
A failure in energy metabolism and antioxidant uptake precede symptoms of Huntington's disease in mice.
Acuña AI, Esparza M, Kramm C, Beltrán FA, Parra AV, Cepeda C, Toro CA, Vidal RL, Hetz C, Concha II, Brauchi S, Levine MS, Castro MA
Nature communications 2013;4:2917
Nature communications 2013;4:2917
Pertuzumab counteracts the inhibitory effect of ErbB2 on degradation of ErbB3.
Sak MM, Szymanska M, Bertelsen V, Hasmann M, Madshus IH, Stang E
Carcinogenesis 2013 Sep;34(9):2031-8
Carcinogenesis 2013 Sep;34(9):2031-8
Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.
Huang ML, Sivagurunathan S, Ting S, Jansson PJ, Austin CJ, Kelly M, Semsarian C, Zhang D, Richardson DR
The American journal of pathology 2013 Sep;183(3):745-57
The American journal of pathology 2013 Sep;183(3):745-57
A novel actin cytoskeleton-dependent noncaveolar microdomain composed of homo-oligomeric caveolin-2 for activation of insulin signaling.
Kwon H, Lee J, Jeong K, Jang D, Pak Y
Biochimica et biophysica acta 2013 Oct;1833(10):2176-89
Biochimica et biophysica acta 2013 Oct;1833(10):2176-89
Inflammasome-mediated secretion of IL-1β in human monocytes through TLR2 activation; modulation by dietary fatty acids.
Snodgrass RG, Huang S, Choi IW, Rutledge JC, Hwang DH
Journal of immunology (Baltimore, Md. : 1950) 2013 Oct 15;191(8):4337-47
Journal of immunology (Baltimore, Md. : 1950) 2013 Oct 15;191(8):4337-47
Dopamine transporter endocytic trafficking in striatal dopaminergic neurons: differential dependence on dynamin and the actin cytoskeleton.
Gabriel LR, Wu S, Kearney P, Bellvé KD, Standley C, Fogarty KE, Melikian HE
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Nov 6;33(45):17836-46
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Nov 6;33(45):17836-46
Bile salt-stimulated phospholipid efflux mediated by ABCB4 localized in nonraft membranes.
Morita SY, Tsuda T, Horikami M, Teraoka R, Kitagawa S, Terada T
Journal of lipid research 2013 May;54(5):1221-30
Journal of lipid research 2013 May;54(5):1221-30
A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport.
Steinberg F, Gallon M, Winfield M, Thomas EC, Bell AJ, Heesom KJ, Tavaré JM, Cullen PJ
Nature cell biology 2013 May;15(5):461-71
Nature cell biology 2013 May;15(5):461-71
A role for cargo in Arf-dependent adaptor recruitment.
Caster AH, Sztul E, Kahn RA
The Journal of biological chemistry 2013 May 24;288(21):14788-804
The Journal of biological chemistry 2013 May 24;288(21):14788-804
Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression.
Xu W, Tse YC, Dobie FA, Baudry M, Craig AM, Wong TP, Wang YT
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 27;33(13):5867-5877
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 27;33(13):5867-5877
Postsynaptic density scaffold SAP102 regulates cortical synapse development through EphB and PAK signaling pathway.
Murata Y, Constantine-Paton M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 13;33(11):5040-52
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Mar 13;33(11):5040-52
In vivo cross-linking reveals principally oligomeric forms of α-synuclein and β-synuclein in neurons and non-neural cells.
Dettmer U, Newman AJ, Luth ES, Bartels T, Selkoe D
The Journal of biological chemistry 2013 Mar 1;288(9):6371-85
The Journal of biological chemistry 2013 Mar 1;288(9):6371-85
Exome sequencing and systems biology converge to identify novel mutations in the L-type calcium channel, CACNA1C, linked to autosomal dominant long QT syndrome.
Boczek NJ, Best JM, Tester DJ, Giudicessi JR, Middha S, Evans JM, Kamp TJ, Ackerman MJ
Circulation. Cardiovascular genetics 2013 Jun;6(3):279-89
Circulation. Cardiovascular genetics 2013 Jun;6(3):279-89
Apical sorting of lysoGPI-anchored proteins occurs independent of association with detergent-resistant membranes but dependent on their N-glycosylation.
Castillon GA, Michon L, Watanabe R
Molecular biology of the cell 2013 Jun;24(12):2021-33
Molecular biology of the cell 2013 Jun;24(12):2021-33
Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2-, AP-1-, and Rab22-dependent steps.
Holloway ZG, Velayos-Baeza A, Howell GJ, Levecque C, Ponnambalam S, Sztul E, Monaco AP
Molecular biology of the cell 2013 Jun;24(11):1735-48, S1-8
Molecular biology of the cell 2013 Jun;24(11):1735-48, S1-8
Expression of transferrin receptor 1, proliferating cell nuclear antigen, p27(Kip1) and calbindin in the fetal and neonatal feline cerebellar cortex.
Poncelet L, Springinsfeld M, Ando K, Héraud C, Kabova A, Brion JP
Veterinary journal (London, England : 1997) 2013 Jun;196(3):388-93
Veterinary journal (London, England : 1997) 2013 Jun;196(3):388-93
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism.
Lane DJ, Chikhani S, Richardson V, Richardson DR
Biochimica et biophysica acta 2013 Jun;1833(6):1527-41
Biochimica et biophysica acta 2013 Jun;1833(6):1527-41
Ubiquilin-1 modulates γ-secretase-mediated ε-site cleavage in neuronal cells.
Viswanathan J, Haapasalo A, Kurkinen KM, Natunen T, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Hiltunen M
Biochemistry 2013 Jun 4;52(22):3899-912
Biochemistry 2013 Jun 4;52(22):3899-912
Nerve growth factor-induced endocytosis of TWIK-related acid-sensitive K⁺ 1 channels in adrenal medullary cells and PC12 cells.
Matsuoka H, Harada K, Nakamura J, Inoue M
Pflugers Archiv : European journal of physiology 2013 Jul;465(7):1051-64
Pflugers Archiv : European journal of physiology 2013 Jul;465(7):1051-64
The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action.
Lui GY, Obeidy P, Ford SJ, Tselepis C, Sharp DM, Jansson PJ, Kalinowski DS, Kovacevic Z, Lovejoy DB, Richardson DR
Molecular pharmacology 2013 Jan;83(1):179-90
Molecular pharmacology 2013 Jan;83(1):179-90
The HSP90 inhibitor geldanamycin perturbs endosomal structure and drives recycling ErbB2 and transferrin to modified MVBs/lysosomal compartments.
Cortese K, Howes MT, Lundmark R, Tagliatti E, Bagnato P, Petrelli A, Bono M, McMahon HT, Parton RG, Tacchetti C
Molecular biology of the cell 2013 Jan;24(2):129-44
Molecular biology of the cell 2013 Jan;24(2):129-44
Antibody affinity maturation using yeast display with detergent-solubilized membrane proteins as antigen sources.
Tillotson BJ, de Larrinoa IF, Skinner CA, Klavas DM, Shusta EV
Protein engineering, design & selection : PEDS 2013 Feb;26(2):101-12
Protein engineering, design & selection : PEDS 2013 Feb;26(2):101-12
Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.
Martineau M, Shi T, Puyal J, Knolhoff AM, Dulong J, Gasnier B, Klingauf J, Sweedler JV, Jahn R, Mothet JP
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Feb 20;33(8):3413-23
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Feb 20;33(8):3413-23
Brain angiotensin regulates iron homeostasis in dopaminergic neurons and microglial cells.
Garrido-Gil P, Rodriguez-Pallares J, Dominguez-Meijide A, Guerra MJ, Labandeira-Garcia JL
Experimental neurology 2013 Dec;250:384-96
Experimental neurology 2013 Dec;250:384-96
Immunocytochemical and biochemical detection of the urokinase-type plasminogen activator receptor (uPAR) in the rat tooth germ and in lipid rafts of PMA-stimulated dental epithelial cells.
von Germar A, Barth K, Schwab W
Histochemistry and cell biology 2013 Dec;140(6):649-58
Histochemistry and cell biology 2013 Dec;140(6):649-58
Coxiella burnetii effector protein subverts clathrin-mediated vesicular trafficking for pathogen vacuole biogenesis.
Larson CL, Beare PA, Howe D, Heinzen RA
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):E4770-9
Proceedings of the National Academy of Sciences of the United States of America 2013 Dec 3;110(49):E4770-9
Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes.
Tornieri K, Zlatic SA, Mullin AP, Werner E, Harrison R, L'hernault SW, Faundez V
Human molecular genetics 2013 Dec 20;22(25):5215-28
Human molecular genetics 2013 Dec 20;22(25):5215-28
Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.
Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I
Nature medicine 2013 Aug;19(8):1030-8
Nature medicine 2013 Aug;19(8):1030-8
Fer protein-tyrosine kinase promotes lung adenocarcinoma cell invasion and tumor metastasis.
Ahn J, Truesdell P, Meens J, Kadish C, Yang X, Boag AH, Craig AW
Molecular cancer research : MCR 2013 Aug;11(8):952-63
Molecular cancer research : MCR 2013 Aug;11(8):952-63
Activity-induced convergence of APP and BACE-1 in acidic microdomains via an endocytosis-dependent pathway.
Das U, Scott DA, Ganguly A, Koo EH, Tang Y, Roy S
Neuron 2013 Aug 7;79(3):447-60
Neuron 2013 Aug 7;79(3):447-60
M98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cells.
Sirohi K, Chalasani ML, Sudhakar C, Kumari A, Radha V, Swarup G
Autophagy 2013 Apr;9(4):510-27
Autophagy 2013 Apr;9(4):510-27
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.
Scotti E, Calamai M, Goulbourne CN, Zhang L, Hong C, Lin RR, Choi J, Pilch PF, Fong LG, Zou P, Ting AY, Pavone FS, Young SG, Tontonoz P
Molecular and cellular biology 2013 Apr;33(8):1503-14
Molecular and cellular biology 2013 Apr;33(8):1503-14
The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites.
Duman JG, Tzeng CP, Tu YK, Munjal T, Schwechter B, Ho TS, Tolias KF
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 17;33(16):6964-78
The Journal of neuroscience : the official journal of the Society for Neuroscience 2013 Apr 17;33(16):6964-78
Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptase.
Larsen BR, Steffensen SD, Nielsen NV, Friis S, Godiksen S, Bornholdt J, Soendergaard C, Nonboe AW, Andersen MN, Poulsen SS, Szabo R, Bugge TH, Lin CY, Skovbjerg H, Jensen JK, Vogel LK
Experimental cell research 2013 Apr 1;319(6):918-29
Experimental cell research 2013 Apr 1;319(6):918-29
CXC chemokine receptor 7 (CXCR7) regulates CXCR4 protein expression and capillary tuft development in mouse kidney.
Haege S, Einer C, Thiele S, Mueller W, Nietzsche S, Lupp A, Mackay F, Schulz S, Stumm R
PloS one 2012;7(8):e42814
PloS one 2012;7(8):e42814
Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes.
Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, Vallentin A, Vial H, Vidal M, Szakacs G
PloS one 2012;7(5):e37378
PloS one 2012;7(5):e37378
Angiotensin II requires zinc and downregulation of the zinc transporters ZnT3 and ZnT10 to induce senescence of vascular smooth muscle cells.
Patrushev N, Seidel-Rogol B, Salazar G
PloS one 2012;7(3):e33211
PloS one 2012;7(3):e33211
X-ray fluorescence imaging: a new tool for studying manganese neurotoxicity.
Robison G, Zakharova T, Fu S, Jiang W, Fulper R, Barrea R, Marcus MA, Zheng W, Pushkar Y
PloS one 2012;7(11):e48899
PloS one 2012;7(11):e48899
Tetraspanin15 regulates cellular trafficking and activity of the ectodomain sheddase ADAM10.
Prox J, Willenbrock M, Weber S, Lehmann T, Schmidt-Arras D, Schwanbeck R, Saftig P, Schwake M
Cellular and molecular life sciences : CMLS 2012 Sep;69(17):2919-32
Cellular and molecular life sciences : CMLS 2012 Sep;69(17):2919-32
LIV-1 ZIP ectodomain shedding in prion-infected mice resembles cellular response to transition metal starvation.
Ehsani S, Salehzadeh A, Huo H, Reginold W, Pocanschi CL, Ren H, Wang H, So K, Sato C, Mehrabian M, Strome R, Trimble WS, Hazrati LN, Rogaeva E, Westaway D, Carlson GA, Schmitt-Ulms G
Journal of molecular biology 2012 Sep 28;422(4):556-574
Journal of molecular biology 2012 Sep 28;422(4):556-574
Arenavirus infection induces discrete cytosolic structures for RNA replication.
Baird NL, York J, Nunberg JH
Journal of virology 2012 Oct;86(20):11301-10
Journal of virology 2012 Oct;86(20):11301-10
α-Hemoglobin-stabilizing protein is a sensitive and specific marker of erythroid precursors.
Raess PW, Paessler ME, Bagg A, Weiss MJ, Choi JK
The American journal of surgical pathology 2012 Oct;36(10):1538-47
The American journal of surgical pathology 2012 Oct;36(10):1538-47
Micromanaging Iron Homeostasis: hypoxia-inducible micro-RNA-210 suppresses iron homeostasis-related proteins.
Yoshioka Y, Kosaka N, Ochiya T, Kato T
The Journal of biological chemistry 2012 Oct 5;287(41):34110-9
The Journal of biological chemistry 2012 Oct 5;287(41):34110-9
Nitric oxide induces segregation of decay accelerating factor (DAF or CD55) from the membrane lipid-rafts and its internalization in human endometrial cells.
Banadakoppa M, Goluszko P, Liebenthal D, Yallampalli C
Cell biology international 2012 Oct 1;36(10):901-7
Cell biology international 2012 Oct 1;36(10):901-7
Dynamic and transient interactions of Atg9 with autophagosomes, but not membrane integration, are required for autophagy.
Orsi A, Razi M, Dooley HC, Robinson D, Weston AE, Collinson LM, Tooze SA
Molecular biology of the cell 2012 May;23(10):1860-73
Molecular biology of the cell 2012 May;23(10):1860-73
Interaction of influenza A virus matrix protein with RACK1 is required for virus release.
Demirov D, Gabriel G, Schneider C, Hohenberg H, Ludwig S
Cellular microbiology 2012 May;14(5):774-89
Cellular microbiology 2012 May;14(5):774-89
Activation of P2X7R and downstream effects in bleomycin treated lung epithelial cells.
Bläsche R, Ebeling G, Perike S, Weinhold K, Kasper M, Barth K
The international journal of biochemistry & cell biology 2012 Mar;44(3):514-24
The international journal of biochemistry & cell biology 2012 Mar;44(3):514-24
Differential expression of potassium channels in placentas from normal and pathological pregnancies: targeting of the K(ir) 2.1 channel to lipid rafts.
Riquelme G, de Gregorio N, Vallejos C, Berrios M, Morales B
The Journal of membrane biology 2012 Mar;245(3):141-50
The Journal of membrane biology 2012 Mar;245(3):141-50
Immunophenotyping invasive breast cancer: paving the road for molecular imaging.
Vermeulen JF, van Brussel AS, van der Groep P, Morsink FH, Bult P, van der Wall E, van Diest PJ
BMC cancer 2012 Jun 13;12:240
BMC cancer 2012 Jun 13;12:240
Suppressed hepcidin expression correlates with hypotransferrinemia in copper-deficient rat pups but not dams.
Broderius M, Mostad E, Prohaska JR
Genes & nutrition 2012 Jul;7(3):405-14
Genes & nutrition 2012 Jul;7(3):405-14
Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis.
Blanc L, Ciciotte SL, Gwynn B, Hildick-Smith GJ, Pierce EL, Soltis KA, Cooney JD, Paw BH, Peters LL
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 24;109(30):12099-104
Proceedings of the National Academy of Sciences of the United States of America 2012 Jul 24;109(30):12099-104
Transmembrane domain determinants of CD4 Downregulation by HIV-1 Vpu.
Magadán JG, Bonifacino JS
Journal of virology 2012 Jan;86(2):757-72
Journal of virology 2012 Jan;86(2):757-72
Bp44mT: an orally active iron chelator of the thiosemicarbazone class with potent anti-tumour efficacy.
Yu Y, Suryo Rahmanto Y, Richardson DR
British journal of pharmacology 2012 Jan;165(1):148-66
British journal of pharmacology 2012 Jan;165(1):148-66
Cullin-3 regulates late endosome maturation.
Huotari J, Meyer-Schaller N, Hubner M, Stauffer S, Katheder N, Horvath P, Mancini R, Helenius A, Peter M
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 17;109(3):823-8
Proceedings of the National Academy of Sciences of the United States of America 2012 Jan 17;109(3):823-8
GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
Chen Z, Kolokoltsov AA, Wang J, Adhikary S, Lorinczi M, Elferink LA, Davey RA
Journal of virology 2012 Feb;86(3):1421-32
Journal of virology 2012 Feb;86(3):1421-32
Anti-melanogenic property of geoditin A in murine B16 melanoma cells.
Cheung FWK, Guo J, Ling YH, Che CT, Liu WK
Marine drugs 2012 Feb;10(2):465-476
Marine drugs 2012 Feb;10(2):465-476
Human CD72 splicing isoform responsible for resistance to systemic lupus erythematosus regulates serum immunoglobulin level and is localized in endoplasmic reticulum.
Hitomi Y, Adachi T, Tsuchiya N, Honda Z, Tokunaga K, Tsubata T
BMC immunology 2012 Dec 26;13:72
BMC immunology 2012 Dec 26;13:72
The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization.
de Kreuk BJ, Anthony EC, Geerts D, Hordijk PL
The Journal of biological chemistry 2012 Dec 21;287(52):43438-53
The Journal of biological chemistry 2012 Dec 21;287(52):43438-53
RIN1 orchestrates the activation of RAB5 GTPases and ABL tyrosine kinases to determine the fate of EGFR.
Balaji K, Mooser C, Janson CM, Bliss JM, Hojjat H, Colicelli J
Journal of cell science 2012 Dec 1;125(Pt 23):5887-96
Journal of cell science 2012 Dec 1;125(Pt 23):5887-96
ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.
Weeks A, Okolowsky N, Golbourn B, Ivanchuk S, Smith C, Rutka JT
The American journal of pathology 2012 Aug;181(2):662-74
The American journal of pathology 2012 Aug;181(2):662-74
Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.
Gleichman AJ, Spruce LA, Dalmau J, Seeholzer SH, Lynch DR
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Aug 8;32(32):11082-94
The Journal of neuroscience : the official journal of the Society for Neuroscience 2012 Aug 8;32(32):11082-94
Rapid uptake and degradation of CXCL12 depend on CXCR7 carboxyl-terminal serine/threonine residues.
Hoffmann F, Müller W, Schütz D, Penfold ME, Wong YH, Schulz S, Stumm R
The Journal of biological chemistry 2012 Aug 17;287(34):28362-77
The Journal of biological chemistry 2012 Aug 17;287(34):28362-77
Activation of myeloid cell-specific adhesion class G protein-coupled receptor EMR2 via ligation-induced translocation and interaction of receptor subunits in lipid raft microdomains.
Huang YS, Chiang NY, Hu CH, Hsiao CC, Cheng KF, Tsai WP, Yona S, Stacey M, Gordon S, Chang GW, Lin HH
Molecular and cellular biology 2012 Apr;32(8):1408-20
Molecular and cellular biology 2012 Apr;32(8):1408-20
Stellettin A induces endoplasmic reticulum stress in murine B16 melanoma cells.
Liu WK, Ling YH, Cheung FW, Che CT
Journal of natural products 2012 Apr 27;75(4):586-90
Journal of natural products 2012 Apr 27;75(4):586-90
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor Nef.
Breuer S, Schievink SI, Schulte A, Blankenfeldt W, Fackler OT, Geyer M
PloS one 2011;6(5):e20033
PloS one 2011;6(5):e20033
A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins.
Milkereit R, Rotin D
PloS one 2011;6(11):e27478
PloS one 2011;6(11):e27478
Relationship between localization on cellular membranes and cytotoxicity of Vibrio vulnificus hemolysin.
Sugiyama H, Kashimoto T, Ueno S, Ehara H, Kodama T, Iida T, Susa N
PloS one 2011;6(10):e26018
PloS one 2011;6(10):e26018
MICAL-like1 mediates epidermal growth factor receptor endocytosis.
Abou-Zeid N, Pandjaitan R, Sengmanivong L, David V, Le Pavec G, Salamero J, Zahraoui A
Molecular biology of the cell 2011 Sep;22(18):3431-41
Molecular biology of the cell 2011 Sep;22(18):3431-41
Functional ESCRT machinery is required for constitutive recycling of claudin-1 and maintenance of polarity in vertebrate epithelial cells.
Dukes JD, Fish L, Richardson JD, Blaikley E, Burns S, Caunt CJ, Chalmers AD, Whitley P
Molecular biology of the cell 2011 Sep;22(17):3192-205
Molecular biology of the cell 2011 Sep;22(17):3192-205
Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.
Chorin E, Vinograd O, Fleidervish I, Gilad D, Herrmann S, Sekler I, Aizenman E, Hershfinkel M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 7;31(36):12916-26
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Sep 7;31(36):12916-26
The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo.
Moroishi T, Nishiyama M, Takeda Y, Iwai K, Nakayama KI
Cell metabolism 2011 Sep 7;14(3):339-51
Cell metabolism 2011 Sep 7;14(3):339-51
Lipid raft endocytosis and exosomal transport facilitate extracellular trafficking of annexin A2.
Valapala M, Vishwanatha JK
The Journal of biological chemistry 2011 Sep 2;286(35):30911-30925
The Journal of biological chemistry 2011 Sep 2;286(35):30911-30925
Antagonistic regulation of cystic fibrosis transmembrane conductance regulator cell surface expression by protein kinases WNK4 and spleen tyrosine kinase.
Mendes AI, Matos P, Moniz S, Luz S, Amaral MD, Farinha CM, Jordan P
Molecular and cellular biology 2011 Oct;31(19):4076-86
Molecular and cellular biology 2011 Oct;31(19):4076-86
Mutations in TRPV4 cause an inherited arthropathy of hands and feet.
Lamandé SR, Yuan Y, Gresshoff IL, Rowley L, Belluoccio D, Kaluarachchi K, Little CB, Botzenhart E, Zerres K, Amor DJ, Cole WG, Savarirayan R, McIntyre P, Bateman JF
Nature genetics 2011 Oct 2;43(11):1142-6
Nature genetics 2011 Oct 2;43(11):1142-6
A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.
Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P, Humphries MJ
Developmental cell 2011 Oct 18;21(4):681-93
Developmental cell 2011 Oct 18;21(4):681-93
Expression and distribution of nucleoside transporter proteins in the human syncytiotrophoblast.
Errasti-Murugarren E, Díaz P, Godoy V, Riquelme G, Pastor-Anglada M
Molecular pharmacology 2011 Nov;80(5):809-17
Molecular pharmacology 2011 Nov;80(5):809-17
The human herpesvirus-7 (HHV-7) U21 immunoevasin subverts NK-mediated cytoxicity through modulation of MICA and MICB.
Schneider CL, Hudson AW
PLoS pathogens 2011 Nov;7(11):e1002362
PLoS pathogens 2011 Nov;7(11):e1002362
ATP9B, a P4-ATPase (a putative aminophospholipid translocase), localizes to the trans-Golgi network in a CDC50 protein-independent manner.
Takatsu H, Baba K, Shima T, Umino H, Kato U, Umeda M, Nakayama K, Shin HW
The Journal of biological chemistry 2011 Nov 4;286(44):38159-38167
The Journal of biological chemistry 2011 Nov 4;286(44):38159-38167
Comparison of changes in gene expression of transferrin receptor-1 and other iron-regulatory proteins in rat liver and brain during acute-phase response.
Malik IA, Naz N, Sheikh N, Khan S, Moriconi F, Blaschke M, Ramadori G
Cell and tissue research 2011 May;344(2):299-312
Cell and tissue research 2011 May;344(2):299-312
Small GTPase Rab11b regulates degradation of surface membrane L-type Cav1.2 channels.
Best JM, Foell JD, Buss CR, Delisle BP, Balijepalli RC, January CT, Kamp TJ
American journal of physiology. Cell physiology 2011 May;300(5):C1023-33
American journal of physiology. Cell physiology 2011 May;300(5):C1023-33
Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.
Zlatic SA, Tornieri K, L'Hernault SW, Faundez V
Molecular biology of the cell 2011 May 15;22(10):1699-715
Molecular biology of the cell 2011 May 15;22(10):1699-715
Transferrin receptor expression in canine lymphoma.
Priest H, McDonough S, Erb H, Daddona J, Stokol T
Veterinary pathology 2011 Mar;48(2):466-74
Veterinary pathology 2011 Mar;48(2):466-74
Glycosylphosphatidylinositol-linked ceruloplasmin is expressed in multiple rodent organs and is lower following dietary copper deficiency.
Mostad EJ, Prohaska JR
Experimental biology and medicine (Maywood, N.J.) 2011 Mar;236(3):298-308
Experimental biology and medicine (Maywood, N.J.) 2011 Mar;236(3):298-308
Aberrant expression of TfR1/CD71 in thyroid carcinomas identifies a novel potential diagnostic marker and therapeutic target.
Magro G, Cataldo I, Amico P, Torrisi A, Vecchio GM, Parenti R, Asioli S, Recupero D, D'Agata V, Mucignat MT, Perris R
Thyroid : official journal of the American Thyroid Association 2011 Mar;21(3):267-77
Thyroid : official journal of the American Thyroid Association 2011 Mar;21(3):267-77
COMMD1-mediated ubiquitination regulates CFTR trafficking.
Drévillon L, Tanguy G, Hinzpeter A, Arous N, de Becdelièvre A, Aissat A, Tarze A, Goossens M, Fanen P
PloS one 2011 Mar 31;6(3):e18334
PloS one 2011 Mar 31;6(3):e18334
Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells.
Dutt S, Narla A, Lin K, Mullally A, Abayasekara N, Megerdichian C, Wilson FH, Currie T, Khanna-Gupta A, Berliner N, Kutok JL, Ebert BL
Blood 2011 Mar 3;117(9):2567-76
Blood 2011 Mar 3;117(9):2567-76
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking.
Sarajärvi T, Tuusa JT, Haapasalo A, Lackman JJ, Sormunen R, Helisalmi S, Roehr JT, Parrado AR, Mäkinen P, Bertram L, Soininen H, Tanzi RE, Petäjä-Repo UE, Hiltunen M
Molecular and cellular biology 2011 Jun;31(11):2326-40
Molecular and cellular biology 2011 Jun;31(11):2326-40
Lipid rafts and cytoskeletal proteins in placental microvilli membranes from preeclamptic and IUGR pregnancies.
Riquelme G, Vallejos C, de Gregorio N, Morales B, Godoy V, Berrios M, Bastías N, Rodríguez C
The Journal of membrane biology 2011 Jun;241(3):127-40
The Journal of membrane biology 2011 Jun;241(3):127-40
SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.
Temkin P, Lauffer B, Jäger S, Cimermancic P, Krogan NJ, von Zastrow M
Nature cell biology 2011 Jun;13(6):715-21
Nature cell biology 2011 Jun;13(6):715-21
Bleomycin treatment of A549 human lung cancer cells results in association of MGr1-Ag and caveolin-1 in lipid rafts.
Linge A, Meleady P, Henry M, Clynes M, Kasper M, Barth K
The international journal of biochemistry & cell biology 2011 Jan;43(1):98-105
The international journal of biochemistry & cell biology 2011 Jan;43(1):98-105
Transferrin receptor gene and protein expression and localization in human IUGR and normal term placentas.
Mandò C, Tabano S, Colapietro P, Pileri P, Colleoni F, Avagliano L, Doi P, Bulfamante G, Miozzo M, Cetin I
Placenta 2011 Jan;32(1):44-50
Placenta 2011 Jan;32(1):44-50
Transient expression of iron transport proteins in the capillary of the developing rat brain.
Yang WM, Jung KJ, Lee MO, Lee YS, Lee YH, Nakagawa S, Niwa M, Cho SS, Kim DW
Cellular and molecular neurobiology 2011 Jan;31(1):93-9
Cellular and molecular neurobiology 2011 Jan;31(1):93-9
Acetaldehyde/alcohol dehydrogenase-2 (EhADH2) and clathrin are involved in internalization of human transferrin by Entamoeba histolytica.
Reyes-López M, Bermúdez-Cruz RM, Avila EE, de la Garza M
Microbiology (Reading, England) 2011 Jan;157(Pt 1):209-219
Microbiology (Reading, England) 2011 Jan;157(Pt 1):209-219
Protein kinase CK2 associates to lipid rafts and its pharmacological inhibition enhances neurotransmitter release.
Gil C, Falqués A, Sarró E, Cubi R, Blasi J, Aguilera J, Itarte E
FEBS letters 2011 Jan 21;585(2):414-20
FEBS letters 2011 Jan 21;585(2):414-20
Recruitment and activation of a lipid kinase by hepatitis C virus NS5A is essential for integrity of the membranous replication compartment.
Reiss S, Rebhan I, Backes P, Romero-Brey I, Erfle H, Matula P, Kaderali L, Poenisch M, Blankenburg H, Hiet MS, Longerich T, Diehl S, Ramirez F, Balla T, Rohr K, Kaul A, Bühler S, Pepperkok R, Lengauer T, Albrecht M, Eils R, Schirmacher P, Lohmann V, Bartenschlager R
Cell host & microbe 2011 Jan 20;9(1):32-45
Cell host & microbe 2011 Jan 20;9(1):32-45
Automated analysis of neuronal morphology, synapse number and synaptic recruitment.
Schmitz SK, Hjorth JJ, Joemai RM, Wijntjes R, Eijgenraam S, de Bruijn P, Georgiou C, de Jong AP, van Ooyen A, Verhage M, Cornelisse LN, Toonen RF, Veldkamp WJ
Journal of neuroscience methods 2011 Feb 15;195(2):185-93
Journal of neuroscience methods 2011 Feb 15;195(2):185-93
Na+/H+ exchanger isoform 6 (NHE6/SLC9A6) is involved in clathrin-dependent endocytosis of transferrin.
Xinhan L, Matsushita M, Numaza M, Taguchi A, Mitsui K, Kanazawa H
American journal of physiology. Cell physiology 2011 Dec;301(6):C1431-44
American journal of physiology. Cell physiology 2011 Dec;301(6):C1431-44
The endocytic uptake pathways of targeted toxins are influenced by synergistically acting Gypsophila saponins.
Bachran D, Schneider S, Bachran C, Weng A, Melzig MF, Fuchs H
Molecular pharmaceutics 2011 Dec 5;8(6):2262-72
Molecular pharmaceutics 2011 Dec 5;8(6):2262-72
Iron accumulation and neurotoxicity in cortical cultures treated with holotransferrin.
Chen-Roetling J, Liu W, Regan RF
Free radical biology & medicine 2011 Dec 1;51(11):1966-74
Free radical biology & medicine 2011 Dec 1;51(11):1966-74
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.
Selvais C, D'Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, Dedieu S, Noël A, Nagase H, Henriet P, Courtoy PJ, Marbaix E, Emonard H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Aug;25(8):2770-81
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Aug;25(8):2770-81
Functional analysis of the RNF114 psoriasis susceptibility gene implicates innate immune responses to double-stranded RNA in disease pathogenesis.
Bijlmakers MJ, Kanneganti SK, Barker JN, Trembath RC, Capon F
Human molecular genetics 2011 Aug 15;20(16):3129-37
Human molecular genetics 2011 Aug 15;20(16):3129-37
Ca2+ induces clustering of membrane proteins in the plasma membrane via electrostatic interactions.
Zilly FE, Halemani ND, Walrafen D, Spitta L, Schreiber A, Jahn R, Lang T
The EMBO journal 2011 Apr 6;30(7):1209-20
The EMBO journal 2011 Apr 6;30(7):1209-20
Cellular iron depletion stimulates the JNK and p38 MAPK signaling transduction pathways, dissociation of ASK1-thioredoxin, and activation of ASK1.
Yu Y, Richardson DR
The Journal of biological chemistry 2011 Apr 29;286(17):15413-27
The Journal of biological chemistry 2011 Apr 29;286(17):15413-27
Disease-associated GPR56 mutations cause bilateral frontoparietal polymicrogyria via multiple mechanisms.
Chiang NY, Hsiao CC, Huang YS, Chen HY, Hsieh IJ, Chang GW, Lin HH
The Journal of biological chemistry 2011 Apr 22;286(16):14215-25
The Journal of biological chemistry 2011 Apr 22;286(16):14215-25
Transport of the major myelin proteolipid protein is directed by VAMP3 and VAMP7.
Feldmann A, Amphornrat J, Schönherr M, Winterstein C, Möbius W, Ruhwedel T, Danglot L, Nave KA, Galli T, Bruns D, Trotter J, Krämer-Albers EM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 13;31(15):5659-72
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 13;31(15):5659-72
T1alpha/podoplanin shows raft-associated distribution in mouse lung alveolar epithelial E10 cells.
Barth K, Bläsche R, Kasper M
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(1):103-12
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2010;25(1):103-12
Short- and medium-chain fatty acids enhance the cell surface expression and transport capacity of the bile salt export pump (BSEP/ABCB11).
Kato T, Hayashi H, Sugiyama Y
Biochimica et biophysica acta 2010 Sep;1801(9):1005-12
Biochimica et biophysica acta 2010 Sep;1801(9):1005-12
CD71 (transferrin receptor): an effective marker for erythroid precursors in bone marrow biopsy specimens.
Marsee DK, Pinkus GS, Yu H
American journal of clinical pathology 2010 Sep;134(3):429-35
American journal of clinical pathology 2010 Sep;134(3):429-35
A single seizure episode leads to rapid functional activation of KCC2 in the neonatal rat hippocampus.
Khirug S, Ahmad F, Puskarjov M, Afzalov R, Kaila K, Blaesse P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Sep 8;30(36):12028-35
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Sep 8;30(36):12028-35
Molecular characterization of a trafficking organelle: dissecting the axonal paths of calsyntenin-1 transport vesicles.
Steuble M, Gerrits B, Ludwig A, Mateos JM, Diep TM, Tagaya M, Stephan A, Schätzle P, Kunz B, Streit P, Sonderegger P
Proteomics 2010 Nov;10(21):3775-88
Proteomics 2010 Nov;10(21):3775-88
Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal.
Skorokhod OA, Caione L, Marrocco T, Migliardi G, Barrera V, Arese P, Piacibello W, Schwarzer E
Blood 2010 Nov 18;116(20):4328-37
Blood 2010 Nov 18;116(20):4328-37
Flotillin microdomains interact with the cortical cytoskeleton to control uropod formation and neutrophil recruitment.
Ludwig A, Otto GP, Riento K, Hams E, Fallon PG, Nichols BJ
The Journal of cell biology 2010 Nov 15;191(4):771-81
The Journal of cell biology 2010 Nov 15;191(4):771-81
Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin.
Evers BM, Farooqi MS, Shelton JM, Richardson JA, Goldstein JL, Brown MS, Liang G
The Journal of investigative dermatology 2010 May;130(5):1237-48
The Journal of investigative dermatology 2010 May;130(5):1237-48
Ebola virus uses clathrin-mediated endocytosis as an entry pathway.
Bhattacharyya S, Warfield KL, Ruthel G, Bavari S, Aman MJ, Hope TJ
Virology 2010 May 25;401(1):18-28
Virology 2010 May 25;401(1):18-28
Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.
Mizukami S, Ichimura R, Kemmochi S, Wang L, Taniai E, Mitsumori K, Shibutani M
Chemico-biological interactions 2010 May 14;185(3):189-201
Chemico-biological interactions 2010 May 14;185(3):189-201
Inhibition of Abeta aggregation and neurotoxicity by the 39-kDa receptor-associated protein.
Kerr ML, Gasperini R, Gibbs ME, Hou X, Shepherd CE, Strickland DK, Foa L, Lawen A, Small DH
Journal of neurochemistry 2010 Mar;112(5):1199-209
Journal of neurochemistry 2010 Mar;112(5):1199-209
Intracellular lipid droplets contain dynamic pools of sphingomyelin: ADRP binds phospholipids with high affinity.
McIntosh AL, Storey SM, Atshaves BP
Lipids 2010 Jun;45(6):465-77
Lipids 2010 Jun;45(6):465-77
Antibody library screens using detergent-solubilized mammalian cell lysates as antigen sources.
Cho YK, Shusta EV
Protein engineering, design & selection : PEDS 2010 Jul;23(7):567-77
Protein engineering, design & selection : PEDS 2010 Jul;23(7):567-77
Transcriptome dysregulation by anthrax lethal toxin plays a key role in induction of human endothelial cell cytotoxicity.
Rolando M, Stefani C, Flatau G, Auberger P, Mettouchi A, Mhlanga M, Rapp U, Galmiche A, Lemichez E
Cellular microbiology 2010 Jul;12(7):891-905
Cellular microbiology 2010 Jul;12(7):891-905
ZF21 protein regulates cell adhesion and motility.
Nagano M, Hoshino D, Sakamoto T, Kawasaki N, Koshikawa N, Seiki M
The Journal of biological chemistry 2010 Jul 2;285(27):21013-22
The Journal of biological chemistry 2010 Jul 2;285(27):21013-22
Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages.
Barrès C, Blanc L, Bette-Bobillo P, André S, Mamoun R, Gabius HJ, Vidal M
Blood 2010 Jan 21;115(3):696-705
Blood 2010 Jan 21;115(3):696-705
Hermansky-Pudlak protein complexes, AP-3 and BLOC-1, differentially regulate presynaptic composition in the striatum and hippocampus.
Newell-Litwa K, Chintala S, Jenkins S, Pare JF, McGaha L, Smith Y, Faundez V
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jan 20;30(3):820-31
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Jan 20;30(3):820-31
Geoditin A induces oxidative stress and apoptosis on human colon HT29 cells.
Cheung FW, Li C, Che CT, Liu BP, Wang L, Liu WK
Marine drugs 2010 Jan 19;8(1):80-90
Marine drugs 2010 Jan 19;8(1):80-90
Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts.
Nitta T, Kuznetsov Y, McPherson A, Fan H
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 19;107(3):1190-5
Proceedings of the National Academy of Sciences of the United States of America 2010 Jan 19;107(3):1190-5
Cloning and tissue expression of the equine transferrin receptor.
Webb TL, Burnett RC, Avery AC, Olver CS
Veterinary clinical pathology 2010 Dec;39(4):424-32
Veterinary clinical pathology 2010 Dec;39(4):424-32
Syntaxin 4 is required for acid sphingomyelinase activity and apoptotic function.
Perrotta C, Bizzozero L, Cazzato D, Morlacchi S, Assi E, Simbari F, Zhang Y, Gulbins E, Bassi MT, Rosa P, Clementi E
The Journal of biological chemistry 2010 Dec 17;285(51):40240-51
The Journal of biological chemistry 2010 Dec 17;285(51):40240-51
Functional cross-talk between Rab14 and Rab4 through a dual effector, RUFY1/Rabip4.
Yamamoto H, Koga H, Katoh Y, Takahashi S, Nakayama K, Shin HW
Molecular biology of the cell 2010 Aug 1;21(15):2746-55
Molecular biology of the cell 2010 Aug 1;21(15):2746-55
Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling.
Stolp B, Abraham L, Rudolph JM, Fackler OT
Journal of virology 2010 Apr;84(8):3935-48
Journal of virology 2010 Apr;84(8):3935-48
Induction of GST-P-positive proliferative lesions facilitating lipid peroxidation with possible involvement of transferrin receptor up-regulation and ceruloplasmin down-regulation from the early stage of liver tumor promotion in rats.
Mizukami S, Ichimura R, Kemmochi S, Taniai E, Shimamoto K, Ohishi T, Takahashi M, Mitsumori K, Shibutani M
Archives of toxicology 2010 Apr;84(4):319-31
Archives of toxicology 2010 Apr;84(4):319-31
A membrane-proximal region in the C-terminal tail of NHE7 is required for its distribution in the trans-Golgi network, distinct from NHE6 localization at endosomes.
Fukura N, Ohgaki R, Matsushita M, Nakamura N, Mitsui K, Kanazawa H
The Journal of membrane biology 2010 Apr;234(3):149-58
The Journal of membrane biology 2010 Apr;234(3):149-58
Ethanol alters endosomal recycling of human dopamine transporters.
Methner DN, Mayfield RD
The Journal of biological chemistry 2010 Apr 2;285(14):10310-7
The Journal of biological chemistry 2010 Apr 2;285(14):10310-7
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles.
Davis ME, Zuckerman JE, Choi CH, Seligson D, Tolcher A, Alabi CA, Yen Y, Heidel JD, Ribas A
Nature 2010 Apr 15;464(7291):1067-70
Nature 2010 Apr 15;464(7291):1067-70
Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6.
Humphries JD, Byron A, Bass MD, Craig SE, Pinney JW, Knight D, Humphries MJ
Science signaling 2009 Sep 8;2(87):ra51
Science signaling 2009 Sep 8;2(87):ra51
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity.
Ishikawa H, Ma Z, Barber GN
Nature 2009 Oct 8;461(7265):788-92
Nature 2009 Oct 8;461(7265):788-92
Hepatitis C virus NS4B carboxy terminal domain is a membrane binding domain.
Liefhebber JM, Brandt BW, Broer R, Spaan WJ, van Leeuwen HC
Virology journal 2009 May 25;6:62
Virology journal 2009 May 25;6:62
Compartmentalization of epidermal growth factor receptor in liver plasma membrane.
Wang Y, Posner BI, Balbis A
Journal of cellular biochemistry 2009 May 1;107(1):96-103
Journal of cellular biochemistry 2009 May 1;107(1):96-103
Comprehensive analysis of expression, subcellular localization, and cognate pairing of SNARE proteins in oligodendrocytes.
Feldmann A, Winterstein C, White R, Trotter J, Krämer-Albers EM
Journal of neuroscience research 2009 Jun;87(8):1760-72
Journal of neuroscience research 2009 Jun;87(8):1760-72
SLC30A3 (ZnT3) oligomerization by dityrosine bonds regulates its subcellular localization and metal transport capacity.
Salazar G, Falcon-Perez JM, Harrison R, Faundez V
PloS one 2009 Jun 12;4(6):e5896
PloS one 2009 Jun 12;4(6):e5896
Essential role of TGF-beta signaling in glucose-induced cell hypertrophy.
Wu L, Derynck R
Developmental cell 2009 Jul;17(1):35-48
Developmental cell 2009 Jul;17(1):35-48
Nrf2 activity is lost in the spinal cord and its astrocytes of aged mice.
Duan W, Zhang R, Guo Y, Jiang Y, Huang Y, Jiang H, Li C
In vitro cellular & developmental biology. Animal 2009 Jul-Aug;45(7):388-97
In vitro cellular & developmental biology. Animal 2009 Jul-Aug;45(7):388-97
Cellular microvesicle pathways can be targeted to transfer genetic information between non-immune cells.
Skinner AM, O'Neill SL, Kurre P
PloS one 2009 Jul 13;4(7):e6219
PloS one 2009 Jul 13;4(7):e6219
Exosomal sorting of the cytoplasmic domain of bovine leukemia virus TM Env protein.
De Gassart A, Trentin B, Martin M, Hocquellet A, Bette-Bobillo P, Mamoun R, Vidal M
Cell biology international 2009 Jan;33(1):36-48
Cell biology international 2009 Jan;33(1):36-48
Raft aggregation with specific receptor recruitment is required for microglial phagocytosis of Abeta42.
Persaud-Sawin DA, Banach L, Harry GJ
Glia 2009 Feb;57(3):320-35
Glia 2009 Feb;57(3):320-35
Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors.
Youn P, Kim S, Ahn JH, Kim Y, Park JD, Ryu DY
Toxicology letters 2009 Feb 10;184(3):151-8
Toxicology letters 2009 Feb 10;184(3):151-8
Down-regulation of seladin-1 increases BACE1 levels and activity through enhanced GGA3 depletion during apoptosis.
Sarajärvi T, Haapasalo A, Viswanathan J, Mäkinen P, Laitinen M, Soininen H, Hiltunen M
The Journal of biological chemistry 2009 Dec 4;284(49):34433-43
The Journal of biological chemistry 2009 Dec 4;284(49):34433-43
Differential effects of EGFR ligands on endocytic sorting of the receptor.
Roepstorff K, Grandal MV, Henriksen L, Knudsen SL, Lerdrup M, Grøvdal L, Willumsen BM, van Deurs B
Traffic (Copenhagen, Denmark) 2009 Aug;10(8):1115-27
Traffic (Copenhagen, Denmark) 2009 Aug;10(8):1115-27
Induction of persistent colitis by a human commensal, enterotoxigenic Bacteroides fragilis, in wild-type C57BL/6 mice.
Rhee KJ, Wu S, Wu X, Huso DL, Karim B, Franco AA, Rabizadeh S, Golub JE, Mathews LE, Shin J, Sartor RB, Golenbock D, Hamad AR, Gan CM, Housseau F, Sears CL
Infection and immunity 2009 Apr;77(4):1708-18
Infection and immunity 2009 Apr;77(4):1708-18
Isolation of rafts from mouse brain tissue by a detergent-free method.
Persaud-Sawin DA, Lightcap S, Harry GJ
Journal of lipid research 2009 Apr;50(4):759-67
Journal of lipid research 2009 Apr;50(4):759-67
Cell-surface biotinylation to study endocytosis and recycling of occludin.
Nishimura N, Sasaki T
Methods in molecular biology (Clifton, N.J.) 2008;440:89-96
Methods in molecular biology (Clifton, N.J.) 2008;440:89-96
Characterization of the molecular interaction between caveolin-1 and the P2X receptors 4 and 7 in E10 mouse lung alveolar epithelial cells.
Barth K, Weinhold K, Guenther A, Linge A, Gereke M, Kasper M
The international journal of biochemistry & cell biology 2008;40(10):2230-9
The international journal of biochemistry & cell biology 2008;40(10):2230-9
Human RME-8 is involved in membrane trafficking through early endosomes.
Fujibayashi A, Taguchi T, Misaki R, Ohtani M, Dohmae N, Takio K, Yamada M, Gu J, Yamakami M, Fukuda M, Waguri S, Uchiyama Y, Yoshimori T, Sekiguchi K
Cell structure and function 2008;33(1):35-50
Cell structure and function 2008;33(1):35-50
Human RME-8 is involved in membrane trafficking through early endosomes.
Fujibayashi A, Taguchi T, Misaki R, Ohtani M, Dohmae N, Takio K, Yamada M, Gu J, Yamakami M, Fukuda M, Waguri S, Uchiyama Y, Yoshimori T, Sekiguchi K
Cell structure and function 2008;33(1):35-50
Cell structure and function 2008;33(1):35-50
Human Nbp35 is essential for both cytosolic iron-sulfur protein assembly and iron homeostasis.
Stehling O, Netz DJ, Niggemeyer B, Rösser R, Eisenstein RS, Puccio H, Pierik AJ, Lill R
Molecular and cellular biology 2008 Sep;28(17):5517-28
Molecular and cellular biology 2008 Sep;28(17):5517-28
Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells.
Kamemura K, Ito A, Shimazu T, Matsuyama A, Maeda S, Yao TP, Horinouchi S, Khochbin S, Yoshida M
Biochemical and biophysical research communications 2008 Sep 12;374(1):84-9
Biochemical and biophysical research communications 2008 Sep 12;374(1):84-9
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.
Inoue H, Ha VL, Prekeris R, Randazzo PA
Molecular biology of the cell 2008 Oct;19(10):4224-37
Molecular biology of the cell 2008 Oct;19(10):4224-37
Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2.
Grimsey N, Han GS, O'Hara L, Rochford JJ, Carman GM, Siniossoglou S
The Journal of biological chemistry 2008 Oct 24;283(43):29166-74
The Journal of biological chemistry 2008 Oct 24;283(43):29166-74
The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane.
Lineberry N, Su L, Soares L, Fathman CG
The Journal of biological chemistry 2008 Oct 17;283(42):28497-505
The Journal of biological chemistry 2008 Oct 17;283(42):28497-505
Cellular distributions of molecules with altered expression specific to the tumor promotion process from the early stage in a rat two-stage hepatocarcinogenesis model.
Takahashi M, Shibutani M, Woo GH, Inoue K, Fujimoto H, Igarashi K, Kanno J, Hirose M, Nishikawa A
Carcinogenesis 2008 Nov;29(11):2218-26
Carcinogenesis 2008 Nov;29(11):2218-26
Exosome secretion, including the DNA damage-induced p53-dependent secretory pathway, is severely compromised in TSAP6/Steap3-null mice.
Lespagnol A, Duflaut D, Beekman C, Blanc L, Fiucci G, Marine JC, Vidal M, Amson R, Telerman A
Cell death and differentiation 2008 Nov;15(11):1723-33
Cell death and differentiation 2008 Nov;15(11):1723-33
Single vesicle analysis of endocytic fission on microtubules in vitro.
Murray JW, Sarkar S, Wolkoff AW
Traffic (Copenhagen, Denmark) 2008 May;9(5):833-847
Traffic (Copenhagen, Denmark) 2008 May;9(5):833-847
Cholesterol substitution increases the structural heterogeneity of caveolae.
Jansen M, Pietiaïnen VM, Pölönen H, Rasilainen L, Koivusalo M, Ruotsalainen U, Jokitalo E, Ikonen E
The Journal of biological chemistry 2008 May 23;283(21):14610-8
The Journal of biological chemistry 2008 May 23;283(21):14610-8
Human immunodeficiency virus type 1 Nef recruits the guanine exchange factor Vav1 via an unexpected interface into plasma membrane microdomains for association with p21-activated kinase 2 activity.
Rauch S, Pulkkinen K, Saksela K, Fackler OT
Journal of virology 2008 Mar;82(6):2918-29
Journal of virology 2008 Mar;82(6):2918-29
Amphetamine-induced decreases in dopamine transporter surface expression are protein kinase C-independent.
Boudanova E, Navaroli DM, Melikian HE
Neuropharmacology 2008 Mar;54(3):605-12
Neuropharmacology 2008 Mar;54(3):605-12
Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production.
Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimiopoulos S
Neurobiology of disease 2008 Jun;30(3):353-364
Neurobiology of disease 2008 Jun;30(3):353-364
Blood-testis barrier dynamics are regulated by testosterone and cytokines via their differential effects on the kinetics of protein endocytosis and recycling in Sertoli cells.
Yan HH, Mruk DD, Lee WM, Cheng CY
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Jun;22(6):1945-59
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2008 Jun;22(6):1945-59
New world clade B arenaviruses can use transferrin receptor 1 (TfR1)-dependent and -independent entry pathways, and glycoproteins from human pathogenic strains are associated with the use of TfR1.
Flanagan ML, Oldenburg J, Reignier T, Holt N, Hamilton GA, Martin VK, Cannon PM
Journal of virology 2008 Jan;82(2):938-48
Journal of virology 2008 Jan;82(2):938-48
Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.
Singh R, Wangemann P
American journal of physiology. Renal physiology 2008 Jan;294(1):F139-48
American journal of physiology. Renal physiology 2008 Jan;294(1):F139-48
Receptor use by the Whitewater Arroyo virus glycoprotein.
Reignier T, Oldenburg J, Flanagan ML, Hamilton GA, Martin VK, Cannon PM
Virology 2008 Feb 20;371(2):439-46
Virology 2008 Feb 20;371(2):439-46
TRPV5 is internalized via clathrin-dependent endocytosis to enter a Ca2+-controlled recycling pathway.
van de Graaf SF, Rescher U, Hoenderop JG, Verkaart S, Bindels RJ, Gerke V
The Journal of biological chemistry 2008 Feb 15;283(7):4077-86
The Journal of biological chemistry 2008 Feb 15;283(7):4077-86
Altered expression of iron regulatory genes in cirrhotic human livers: clues to the cause of hemosiderosis?
Bergmann OM, Mathahs MM, Broadhurst KA, Weydert JA, Wilkinson N, Howe JR, Han O, Schmidt WN, Brown KE
Laboratory investigation; a journal of technical methods and pathology 2008 Dec;88(12):1349-57
Laboratory investigation; a journal of technical methods and pathology 2008 Dec;88(12):1349-57
Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
Witte V, Laffert B, Gintschel P, Krautkrämer E, Blume K, Fackler OT, Baur AS
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 15;181(12):8425-32
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 15;181(12):8425-32
Induction of HIV transcription by Nef involves Lck activation and protein kinase C theta raft recruitment leading to activation of ERK1/2 but not NF kappa B.
Witte V, Laffert B, Gintschel P, Krautkrämer E, Blume K, Fackler OT, Baur AS
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 15;181(12):8425-32
Journal of immunology (Baltimore, Md. : 1950) 2008 Dec 15;181(12):8425-32
An epigenetic genome-wide screen identifies SPINT2 as a novel tumor suppressor gene in pediatric medulloblastoma.
Kongkham PN, Northcott PA, Ra YS, Nakahara Y, Mainprize TG, Croul SE, Smith CA, Taylor MD, Rutka JT
Cancer research 2008 Dec 1;68(23):9945-53
Cancer research 2008 Dec 1;68(23):9945-53
Inhibition of Abl tyrosine kinase enhances nerve growth factor-mediated signaling in Bcr-Abl transformed cells via the alteration of signaling complex and the receptor turnover.
Koch A, Scherr M, Breyer B, Mancini A, Kardinal C, Battmer K, Eder M, Tamura T
Oncogene 2008 Aug 7;27(34):4678-89
Oncogene 2008 Aug 7;27(34):4678-89
Iron-independent phosphorylation of iron regulatory protein 2 regulates ferritin during the cell cycle.
Wallander ML, Zumbrennen KB, Rodansky ES, Romney SJ, Leibold EA
The Journal of biological chemistry 2008 Aug 29;283(35):23589-98
The Journal of biological chemistry 2008 Aug 29;283(35):23589-98
The RNA-binding protein CUGBP1 regulates stability of tumor necrosis factor mRNA in muscle cells: implications for myotonic dystrophy.
Zhang L, Lee JE, Wilusz J, Wilusz CJ
The Journal of biological chemistry 2008 Aug 15;283(33):22457-63
The Journal of biological chemistry 2008 Aug 15;283(33):22457-63
Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation.
Roberts LM, Black DS, Raman C, Woodford K, Zhou M, Haggerty JE, Yan AT, Cwirla SE, Grindstaff KK
Neuroscience 2008 Aug 13;155(2):423-38
Neuroscience 2008 Aug 13;155(2):423-38
Phosphatidylinositol-4-kinase type II alpha contains an AP-3-sorting motif and a kinase domain that are both required for endosome traffic.
Craige B, Salazar G, Faundez V
Molecular biology of the cell 2008 Apr;19(4):1415-26
Molecular biology of the cell 2008 Apr;19(4):1415-26
Tonic activation of CXC chemokine receptor 4 in immature granule cells supports neurogenesis in the adult dentate gyrus.
Kolodziej A, Schulz S, Guyon A, Wu DF, Pfeiffer M, Odemis V, Höllt V, Stumm R
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 23;28(17):4488-500
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 23;28(17):4488-500
Dynamics of somatostatin type 2A receptor cargoes in living hippocampal neurons.
Lelouvier B, Tamagno G, Kaindl AM, Roland A, Lelievre V, Le Verche V, Loudes C, Gressens P, Faivre-Baumann A, Lenkei Z, Dournaud P
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 23;28(17):4336-49
The Journal of neuroscience : the official journal of the Society for Neuroscience 2008 Apr 23;28(17):4336-49
Rab11-FIP2 regulates differentiable steps in transcytosis.
Ducharme NA, Williams JA, Oztan A, Apodaca G, Lapierre LA, Goldenring JR
American journal of physiology. Cell physiology 2007 Sep;293(3):C1059-72
American journal of physiology. Cell physiology 2007 Sep;293(3):C1059-72
Immunocytochemical and biochemical detection of EMMPRIN in the rat tooth germ: differentiation-dependent co-expression with MMPs and co-localization with caveolin-1 in membrane rafts of dental epithelial cells.
Schwab W, Harada H, Goetz W, Nowicki M, Witt M, Kasper M, Barth K
Histochemistry and cell biology 2007 Sep;128(3):195-203
Histochemistry and cell biology 2007 Sep;128(3):195-203
The ClC-3 chloride transport protein traffics through the plasma membrane via interaction of an N-terminal dileucine cluster with clathrin.
Zhao Z, Li X, Hao J, Winston JH, Weinman SA
The Journal of biological chemistry 2007 Sep 28;282(39):29022-29031
The Journal of biological chemistry 2007 Sep 28;282(39):29022-29031
R7-binding protein targets the G protein beta 5/R7-regulator of G protein signaling complex to lipid rafts in neuronal cells and brain.
Nini L, Waheed AA, Panicker LM, Czapiga M, Zhang JH, Simonds WF
BMC biochemistry 2007 Sep 19;8:18
BMC biochemistry 2007 Sep 19;8:18
Cytoskeletal involvement in the cellular trafficking of plasmid/PEI derivative complexes.
Grosse S, Aron Y, Thévenot G, Monsigny M, Fajac I
Journal of controlled release : official journal of the Controlled Release Society 2007 Sep 11;122(1):111-7
Journal of controlled release : official journal of the Controlled Release Society 2007 Sep 11;122(1):111-7
Localization of the human breast cancer resistance protein (BCRP/ABCG2) in lipid rafts/caveolae and modulation of its activity by cholesterol in vitro.
Storch CH, Ehehalt R, Haefeli WE, Weiss J
The Journal of pharmacology and experimental therapeutics 2007 Oct;323(1):257-64
The Journal of pharmacology and experimental therapeutics 2007 Oct;323(1):257-64
Exocyst requirement for endocytic traffic directed toward the apical and basolateral poles of polarized MDCK cells.
Oztan A, Silvis M, Weisz OA, Bradbury NA, Hsu SC, Goldenring JR, Yeaman C, Apodaca G
Molecular biology of the cell 2007 Oct;18(10):3978-92
Molecular biology of the cell 2007 Oct;18(10):3978-92
The transferrin receptor and the tetraspanin web molecules CD9, CD81, and CD9P-1 are differentially sorted into exosomes after TPA treatment of K562 cells.
Abache T, Le Naour F, Planchon S, Harper F, Boucheix C, Rubinstein E
Journal of cellular biochemistry 2007 Oct 15;102(3):650-64
Journal of cellular biochemistry 2007 Oct 15;102(3):650-64
Human ClC-6 is a late endosomal glycoprotein that associates with detergent-resistant lipid domains.
Ignoul S, Simaels J, Hermans D, Annaert W, Eggermont J
PloS one 2007 May 30;2(5):e474
PloS one 2007 May 30;2(5):e474
Shedding of the p75NTR neurotrophin receptor is modulated by lipid rafts.
Gil C, Cubí R, Aguilera J
FEBS letters 2007 May 1;581(9):1851-8
FEBS letters 2007 May 1;581(9):1851-8
Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha.
Parisiadou L, Efthimiopoulos S
Neurobiology of aging 2007 Mar;28(3):377-88
Neurobiology of aging 2007 Mar;28(3):377-88
Transferrin receptor 2: evidence for ligand-induced stabilization and redirection to a recycling pathway.
Johnson MB, Chen J, Murchison N, Green FA, Enns CA
Molecular biology of the cell 2007 Mar;18(3):743-54
Molecular biology of the cell 2007 Mar;18(3):743-54
The Cytoplasmic domain of transferrin receptor 2 dictates its stability and response to holo-transferrin in Hep3B cells.
Chen J, Enns CA
The Journal of biological chemistry 2007 Mar 2;282(9):6201-9
The Journal of biological chemistry 2007 Mar 2;282(9):6201-9
Compartmentalization of signaling-competent epidermal growth factor receptors in endosomes.
Balbis A, Parmar A, Wang Y, Baquiran G, Posner BI
Endocrinology 2007 Jun;148(6):2944-54
Endocrinology 2007 Jun;148(6):2944-54
Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies.
Goenaga AL, Zhou Y, Legay C, Bougherara H, Huang L, Liu B, Drummond DC, Kirpotin DB, Auclair C, Marks JD, Poul MA
Molecular immunology 2007 Jul;44(15):3777-88
Molecular immunology 2007 Jul;44(15):3777-88
Depletion of the nucleolar protein nucleostemin causes G1 cell cycle arrest via the p53 pathway.
Ma H, Pederson T
Molecular biology of the cell 2007 Jul;18(7):2630-5
Molecular biology of the cell 2007 Jul;18(7):2630-5
The small GTPases Rab5 and RalA regulate intracellular traffic of P-glycoprotein.
Fu D, van Dam EM, Brymora A, Duggin IG, Robinson PJ, Roufogalis BD
Biochimica et biophysica acta 2007 Jul;1773(7):1062-72
Biochimica et biophysica acta 2007 Jul;1773(7):1062-72
Tumor-derived fibronectin is involved in melanoma cell invasion and regulated by V600E B-Raf signaling pathway.
Gaggioli C, Robert G, Bertolotto C, Bailet O, Abbe P, Spadafora A, Bahadoran P, Ortonne JP, Baron V, Ballotti R, Tartare-Deckert S
The Journal of investigative dermatology 2007 Feb;127(2):400-10
The Journal of investigative dermatology 2007 Feb;127(2):400-10
Inefficient targeting to the endoplasmic reticulum by the signal recognition particle elicits selective defects in post-ER membrane trafficking.
Lakkaraju AK, Luyet PP, Parone P, Falguières T, Strub K
Experimental cell research 2007 Feb 15;313(4):834-47
Experimental cell research 2007 Feb 15;313(4):834-47
Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells.
Hida T, Ikeda H, Kametaka S, Akazawa C, Kohsaka S, Ebisu S, Uchiyama Y, Waguri S
Archives of histology and cytology 2007 Dec;70(5):303-12
Archives of histology and cytology 2007 Dec;70(5):303-12
Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells.
Hida T, Ikeda H, Kametaka S, Akazawa C, Kohsaka S, Ebisu S, Uchiyama Y, Waguri S
Archives of histology and cytology 2007 Dec;70(5):303-12
Archives of histology and cytology 2007 Dec;70(5):303-12
Pael receptor is involved in dopamine metabolism in the nigrostriatal system.
Imai Y, Inoue H, Kataoka A, Hua-Qin W, Masuda M, Ikeda T, Tsukita K, Soda M, Kodama T, Fuwa T, Honda Y, Kaneko S, Matsumoto S, Wakamatsu K, Ito S, Miura M, Aosaki T, Itohara S, Takahashi R
Neuroscience research 2007 Dec;59(4):413-25
Neuroscience research 2007 Dec;59(4):413-25
Two pools of Triton X-100-insoluble GABA(A) receptors are present in the brain, one associated to lipid rafts and another one to the post-synaptic GABAergic complex.
Li X, Serwanski DR, Miralles CP, Bahr BA, De Blas AL
Journal of neurochemistry 2007 Aug;102(4):1329-45
Journal of neurochemistry 2007 Aug;102(4):1329-45
BLOC-1 complex deficiency alters the targeting of adaptor protein complex-3 cargoes.
Salazar G, Craige B, Styers ML, Newell-Litwa KA, Doucette MM, Wainer BH, Falcon-Perez JM, Dell'Angelica EC, Peden AA, Werner E, Faundez V
Molecular biology of the cell 2006 Sep;17(9):4014-26
Molecular biology of the cell 2006 Sep;17(9):4014-26
Effects of cholesterol manipulation on the signaling of the human oxytocin receptor.
Reversi A, Rimoldi V, Brambillasca S, Chini B
American journal of physiology. Regulatory, integrative and comparative physiology 2006 Oct;291(4):R861-9
American journal of physiology. Regulatory, integrative and comparative physiology 2006 Oct;291(4):R861-9
Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.
Ng PP, Helguera G, Daniels TR, Lomas SZ, Rodriguez JA, Schiller G, Bonavida B, Morrison SL, Penichet ML
Blood 2006 Oct 15;108(8):2745-54
Blood 2006 Oct 15;108(8):2745-54
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.
Rutherford AC, Traer C, Wassmer T, Pattni K, Bujny MV, Carlton JG, Stenmark H, Cullen PJ
Journal of cell science 2006 Oct 1;119(Pt 19):3944-57
Journal of cell science 2006 Oct 1;119(Pt 19):3944-57
Iron chelators reduce chromosomal breaks in ataxia-telangiectasia cells.
Shackelford RE, Fu Y, Manuszak RP, Brooks TC, Sequeira AP, Wang S, Lowery-Nordberg M, Chen A
DNA repair 2006 Nov 8;5(11):1327-36
DNA repair 2006 Nov 8;5(11):1327-36
Human cytomegalovirus-encoded US2 and US11 target unassembled MHC class I heavy chains for degradation.
Barel MT, Hassink GC, van Voorden S, Wiertz EJ
Molecular immunology 2006 Mar;43(8):1258-66
Molecular immunology 2006 Mar;43(8):1258-66
Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis.
O'Donnell KA, Yu D, Zeller KI, Kim JW, Racke F, Thomas-Tikhonenko A, Dang CV
Molecular and cellular biology 2006 Mar;26(6):2373-86
Molecular and cellular biology 2006 Mar;26(6):2373-86
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation.
Matallanas D, Sanz-Moreno V, Arozarena I, Calvo F, Agudo-Ibáñez L, Santos E, Berciano MT, Crespo P
Molecular and cellular biology 2006 Jan;26(1):100-16
Molecular and cellular biology 2006 Jan;26(1):100-16
Subtle sequence variation among MHC class I locus products greatly influences sensitivity to HCMV US2- and US11-mediated degradation.
Barel MT, Pizzato N, Le Bouteiller P, Wiertz EJ, Lenfant F
International immunology 2006 Jan;18(1):173-82
International immunology 2006 Jan;18(1):173-82
GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi.
Snyder CM, Mardones GA, Ladinsky MS, Howell KE
Molecular biology of the cell 2006 Jan;17(1):511-24
Molecular biology of the cell 2006 Jan;17(1):511-24
Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Lerdrup M, Hommelgaard AM, Grandal M, van Deurs B
Journal of cell science 2006 Jan 1;119(Pt 1):85-95
Journal of cell science 2006 Jan 1;119(Pt 1):85-95
The HIV lipidome: a raft with an unusual composition.
Brügger B, Glass B, Haberkant P, Leibrecht I, Wieland FT, Kräusslich HG
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2641-6
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2641-6
Association of brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) with recycling endosomes during transferrin uptake.
Shen X, Xu KF, Fan Q, Pacheco-Rodriguez G, Moss J, Vaughan M
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2635-40
Proceedings of the National Academy of Sciences of the United States of America 2006 Feb 21;103(8):2635-40
Functional characterization of HIV-1 Nef mutants in the context of viral infection.
Fackler OT, Moris A, Tibroni N, Giese SI, Glass B, Schwartz O, Kräusslich HG
Virology 2006 Aug 1;351(2):322-39
Virology 2006 Aug 1;351(2):322-39
CD2AP, Rabip4, and Rabip4': analysis of interaction with Rab4a and regulation of endosomes morphology.
Monzo P, Mari M, Kaddai V, Gonzalez T, Le Marchand-Brustel Y, Cormont M
Methods in enzymology 2005;403:107-18
Methods in enzymology 2005;403:107-18
Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins.
Engelking LJ, Liang G, Hammer RE, Takaishi K, Kuriyama H, Evers BM, Li WP, Horton JD, Goldstein JL, Brown MS
The Journal of clinical investigation 2005 Sep;115(9):2489-98
The Journal of clinical investigation 2005 Sep;115(9):2489-98
BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production.
Fotinopoulou A, Tsachaki M, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, Ghiso J, Efthimiopoulos S
The Journal of biological chemistry 2005 Sep 2;280(35):30768-72
The Journal of biological chemistry 2005 Sep 2;280(35):30768-72
Two mink parvoviruses use different cellular receptors for entry into CRFK cells.
Park GS, Best SM, Bloom ME
Virology 2005 Sep 15;340(1):1-9
Virology 2005 Sep 15;340(1):1-9
Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner.
Fassa A, Mehta P, Efthimiopoulos S
Journal of neuroscience research 2005 Oct 15;82(2):214-24
Journal of neuroscience research 2005 Oct 15;82(2):214-24
Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes.
Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G
Molecular biology of the cell 2005 Nov;16(11):5356-72
Molecular biology of the cell 2005 Nov;16(11):5356-72
Rat brain iron concentration is lower following perinatal copper deficiency.
Prohaska JR, Gybina AA
Journal of neurochemistry 2005 May;93(3):698-705
Journal of neurochemistry 2005 May;93(3):698-705
Vglut1 and ZnT3 co-targeting mechanisms regulate vesicular zinc stores in PC12 cells.
Salazar G, Craige B, Love R, Kalman D, Faundez V
Journal of cell science 2005 May 1;118(Pt 9):1911-21
Journal of cell science 2005 May 1;118(Pt 9):1911-21
Microanatomy of axon/glial signaling during Wallerian degeneration.
Guertin AD, Zhang DP, Mak KS, Alberta JA, Kim HA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Mar 30;25(13):3478-87
The Journal of neuroscience : the official journal of the Society for Neuroscience 2005 Mar 30;25(13):3478-87
Occult celiac disease prevents penetrance of hemochromatosis.
Geier A, Gartung C, Theurl I, Weiss G, Lammert F, Dietrich CG, Weiskirchen R, Zoller H, Hermanns B, Matern S
World journal of gastroenterology 2005 Jun 7;11(21):3323-6
World journal of gastroenterology 2005 Jun 7;11(21):3323-6
Early events in integrin alphavbeta6-mediated cell entry of foot-and-mouth disease virus.
Berryman S, Clark S, Monaghan P, Jackson T
Journal of virology 2005 Jul;79(13):8519-34
Journal of virology 2005 Jul;79(13):8519-34
Epidermal growth factor receptors are localized to lipid rafts that contain a balance of inner and outer leaflet lipids: a shotgun lipidomics study.
Pike LJ, Han X, Gross RW
The Journal of biological chemistry 2005 Jul 22;280(29):26796-804
The Journal of biological chemistry 2005 Jul 22;280(29):26796-804
Depletion of TSG101 forms a mammalian "Class E" compartment: a multicisternal early endosome with multiple sorting defects.
Doyotte A, Russell MR, Hopkins CR, Woodman PG
Journal of cell science 2005 Jul 15;118(Pt 14):3003-17
Journal of cell science 2005 Jul 15;118(Pt 14):3003-17
Enhanced expression of transferrin receptor confers UV-resistance in human and monkey cells.
Chen Z, Nomura J, Suzuki T, Suzuki N
Journal of radiation research 2005 Dec;46(4):443-51
Journal of radiation research 2005 Dec;46(4):443-51
Enhanced expression of transferrin receptor confers UV-resistance in human and monkey cells.
Chen Z, Nomura J, Suzuki T, Suzuki N
Journal of radiation research 2005 Dec;46(4):443-51
Journal of radiation research 2005 Dec;46(4):443-51
Rab15 effector protein: a novel protein for receptor recycling from the endocytic recycling compartment.
Strick DJ, Elferink LA
Molecular biology of the cell 2005 Dec;16(12):5699-709
Molecular biology of the cell 2005 Dec;16(12):5699-709
A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation.
Zeng X, Tamai K, Doble B, Li S, Huang H, Habas R, Okamura H, Woodgett J, He X
Nature 2005 Dec 8;438(7069):873-7
Nature 2005 Dec 8;438(7069):873-7
The DnaJ-domain protein RME-8 functions in endosomal trafficking.
Girard M, Poupon V, Blondeau F, McPherson PS
The Journal of biological chemistry 2005 Dec 2;280(48):40135-43
The Journal of biological chemistry 2005 Dec 2;280(48):40135-43
Endocytosis resumes during late mitosis and is required for cytokinesis.
Schweitzer JK, Burke EE, Goodson HV, D'Souza-Schorey C
The Journal of biological chemistry 2005 Dec 16;280(50):41628-35
The Journal of biological chemistry 2005 Dec 16;280(50):41628-35
Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles.
Salazar G, Craige B, Wainer BH, Guo J, De Camilli P, Faundez V
Molecular biology of the cell 2005 Aug;16(8):3692-704
Molecular biology of the cell 2005 Aug;16(8):3692-704
Lowe syndrome protein OCRL1 interacts with clathrin and regulates protein trafficking between endosomes and the trans-Golgi network.
Choudhury R, Diao A, Zhang F, Eisenberg E, Saint-Pol A, Williams C, Konstantakopoulos A, Lucocq J, Johannes L, Rabouille C, Greene LE, Lowe M
Molecular biology of the cell 2005 Aug;16(8):3467-79
Molecular biology of the cell 2005 Aug;16(8):3467-79
Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells.
Alberghini A, Recalcati S, Tacchini L, Santambrogio P, Campanella A, Cairo G
The Journal of biological chemistry 2005 Aug 26;280(34):30120-8
The Journal of biological chemistry 2005 Aug 26;280(34):30120-8
Role for A kinase-anchoring proteins (AKAPS) in glutamate receptor trafficking and long term synaptic depression.
Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF
The Journal of biological chemistry 2005 Apr 29;280(17):16962-16968
The Journal of biological chemistry 2005 Apr 29;280(17):16962-16968
Over-expression of Rififylin, a new RING finger and FYVE-like domain-containing protein, inhibits recycling from the endocytic recycling compartment.
Coumailleau F, Das V, Alcover A, Raposo G, Vandormael-Pournin S, Le Bras S, Baldacci P, Dautry-Varsat A, Babinet C, Cohen-Tannoudji M
Molecular biology of the cell 2004 Oct;15(10):4444-56
Molecular biology of the cell 2004 Oct;15(10):4444-56
Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity.
Burgueño J, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F
Experimental cell research 2004 Oct 15;300(1):23-34
Experimental cell research 2004 Oct 15;300(1):23-34
Trafficking of cholera toxin-ganglioside GM1 complex into Golgi and induction of toxicity depend on actin cytoskeleton.
Badizadegan K, Wheeler HE, Fujinaga Y, Lencer WI
American journal of physiology. Cell physiology 2004 Nov;287(5):C1453-62
American journal of physiology. Cell physiology 2004 Nov;287(5):C1453-62
Adaptive changes of duodenal iron transport proteins in celiac disease.
Barisani D, Parafioriti A, Bardella MT, Zoller H, Conte D, Armiraglio E, Trovato C, Koch RO, Weiss G
Physiological genomics 2004 May 19;17(3):316-25
Physiological genomics 2004 May 19;17(3):316-25
The GDP-bound form of Arf6 is located at the plasma membrane.
Macia E, Luton F, Partisani M, Cherfils J, Chardin P, Franco M
Journal of cell science 2004 May 1;117(Pt 11):2389-98
Journal of cell science 2004 May 1;117(Pt 11):2389-98
Requirements for CEACAMs and cholesterol during murine coronavirus cell entry.
Thorp EB, Gallagher TM
Journal of virology 2004 Mar;78(6):2682-92
Journal of virology 2004 Mar;78(6):2682-92
Lactosylated polyethylenimine for gene transfer into airway epithelial cells: role of the sugar moiety in cell delivery and intracellular trafficking of the complexes.
Grosse S, Aron Y, Honoré I, Thévenot G, Danel C, Roche AC, Monsigny M, Fajac I
The journal of gene medicine 2004 Mar;6(3):345-56
The journal of gene medicine 2004 Mar;6(3):345-56
EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement.
Luton F, Klein S, Chauvin JP, Le Bivic A, Bourgoin S, Franco M, Chardin P
Molecular biology of the cell 2004 Mar;15(3):1134-45
Molecular biology of the cell 2004 Mar;15(3):1134-45
RanBPM is a phosphoprotein that associates with the plasma membrane and interacts with the integrin LFA-1.
Denti S, Sirri A, Cheli A, Rogge L, Innamorati G, Putignano S, Fabbri M, Pardi R, Bianchi E
The Journal of biological chemistry 2004 Mar 26;279(13):13027-34
The Journal of biological chemistry 2004 Mar 26;279(13):13027-34
Sorting of ligand-activated epidermal growth factor receptor to lysosomes requires its actin-binding domain.
Stoorvogel W, Kerstens S, Fritzsche I, den Hartigh JC, Oud R, van der Heyden MA, Voortman J, van Bergen en Henegouwen PM
The Journal of biological chemistry 2004 Mar 19;279(12):11562-9
The Journal of biological chemistry 2004 Mar 19;279(12):11562-9
Regulation of a COPII component by cytosolic O-glycosylation during mitosis.
Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP
FEBS letters 2004 Mar 12;561(1-3):44-50
FEBS letters 2004 Mar 12;561(1-3):44-50
Parvovirus infection of cells by using variants of the feline transferrin receptor altering clathrin-mediated endocytosis, membrane domain localization, and capsid-binding domains.
Hueffer K, Palermo LM, Parrish CR
Journal of virology 2004 Jun;78(11):5601-11
Journal of virology 2004 Jun;78(11):5601-11
Recombinant Escherichia coli as a gene delivery vector into airway epithelial cells.
Fajac I, Grosse S, Collombet JM, Thevenot G, Goussard S, Danel C, Grillot-Courvalin C
Journal of controlled release : official journal of the Controlled Release Society 2004 Jun 18;97(2):371-81
Journal of controlled release : official journal of the Controlled Release Society 2004 Jun 18;97(2):371-81
AP-3-dependent mechanisms control the targeting of a chloride channel (ClC-3) in neuronal and non-neuronal cells.
Salazar G, Love R, Styers ML, Werner E, Peden A, Rodriguez S, Gearing M, Wainer BH, Faundez V
The Journal of biological chemistry 2004 Jun 11;279(24):25430-9
The Journal of biological chemistry 2004 Jun 11;279(24):25430-9
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement.
Batista A, Millán J, Mittelbrunn M, Sánchez-Madrid F, Alonso MA
Journal of immunology (Baltimore, Md. : 1950) 2004 Jun 1;172(11):6709-14
Journal of immunology (Baltimore, Md. : 1950) 2004 Jun 1;172(11):6709-14
Recruitment of transferrin receptor to immunological synapse in response to TCR engagement.
Batista A, Millán J, Mittelbrunn M, Sánchez-Madrid F, Alonso MA
Journal of immunology (Baltimore, Md. : 1950) 2004 Jun 1;172(11):6709-14
Journal of immunology (Baltimore, Md. : 1950) 2004 Jun 1;172(11):6709-14
Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin.
Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF
Molecular biology of the cell 2004 Jul;15(7):3095-105
Molecular biology of the cell 2004 Jul;15(7):3095-105
Structural and functional impairment of endocytic pathways by retinitis pigmentosa mutant rhodopsin-arrestin complexes.
Chuang JZ, Vega C, Jun W, Sung CH
The Journal of clinical investigation 2004 Jul;114(1):131-40
The Journal of clinical investigation 2004 Jul;114(1):131-40
Charge-based separation of detergent-resistant membranes of mouse splenic B cells.
Katsumata O, Kimura T, Nagatsuka Y, Hirabayashi Y, Sugiya H, Furuyama S, Yanagishita M, Hara-Yokoyama M
Biochemical and biophysical research communications 2004 Jul 2;319(3):826-31
Biochemical and biophysical research communications 2004 Jul 2;319(3):826-31
Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.
Kikkert M, Doolman R, Dai M, Avner R, Hassink G, van Voorden S, Thanedar S, Roitelman J, Chau V, Wiertz E
The Journal of biological chemistry 2004 Jan 30;279(5):3525-34
The Journal of biological chemistry 2004 Jan 30;279(5):3525-34
The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation.
Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V
Molecular biology of the cell 2004 Feb;15(2):575-87
Molecular biology of the cell 2004 Feb;15(2):575-87
The endo-lysosomal sorting machinery interacts with the intermediate filament cytoskeleton.
Styers ML, Salazar G, Love R, Peden AA, Kowalczyk AP, Faundez V
Molecular biology of the cell 2004 Dec;15(12):5369-82
Molecular biology of the cell 2004 Dec;15(12):5369-82
BIG2, a guanine nucleotide exchange factor for ADP-ribosylation factors: its localization to recycling endosomes and implication in the endosome integrity.
Shin HW, Morinaga N, Noda M, Nakayama K
Molecular biology of the cell 2004 Dec;15(12):5283-94
Molecular biology of the cell 2004 Dec;15(12):5283-94
Multiple regions contribute to membrane targeting of Rab GTPases.
Ali BR, Wasmeier C, Lamoreux L, Strom M, Seabra MC
Journal of cell science 2004 Dec 15;117(Pt 26):6401-12
Journal of cell science 2004 Dec 15;117(Pt 26):6401-12
Cellular senescence induced loss of stem cell proportion in the skin in vitro.
Youn SW, Kim DS, Cho HJ, Jeon SE, Bae IH, Yoon HJ, Park KC
Journal of dermatological science 2004 Aug;35(2):113-23
Journal of dermatological science 2004 Aug;35(2):113-23
Macropinocytosis of polyplexes and recycling of plasmid via the clathrin-dependent pathway impair the transfection efficiency of human hepatocarcinoma cells.
Gonçalves C, Mennesson E, Fuchs R, Gorvel JP, Midoux P, Pichon C
Molecular therapy : the journal of the American Society of Gene Therapy 2004 Aug;10(2):373-85
Molecular therapy : the journal of the American Society of Gene Therapy 2004 Aug;10(2):373-85
Human immunodeficiency virus type 1 Nef activates p21-activated kinase via recruitment into lipid rafts.
Krautkrämer E, Giese SI, Gasteier JE, Muranyi W, Fackler OT
Journal of virology 2004 Apr;78(8):4085-97
Journal of virology 2004 Apr;78(8):4085-97
Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor.
Arighi CN, Hartnell LM, Aguilar RC, Haft CR, Bonifacino JS
The Journal of cell biology 2004 Apr;165(1):123-33
The Journal of cell biology 2004 Apr;165(1):123-33
Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis.
Engelking LJ, Kuriyama H, Hammer RE, Horton JD, Brown MS, Goldstein JL, Liang G
The Journal of clinical investigation 2004 Apr;113(8):1168-75
The Journal of clinical investigation 2004 Apr;113(8):1168-75
Cell surface organization of stress-inducible proteins ULBP and MICA that stimulate human NK cells and T cells via NKG2D.
Eleme K, Taner SB, Onfelt B, Collinson LM, McCann FE, Chalupny NJ, Cosman D, Hopkins C, Magee AI, Davis DM
The Journal of experimental medicine 2004 Apr 5;199(7):1005-10
The Journal of experimental medicine 2004 Apr 5;199(7):1005-10
Transferrin [corrected] receptor association and endosomal localization of soluble HFE are not sufficient for regulation of cellular iron homeostasis.
Laham N, Rotem-Yehudar R, Shechter C, Coligan JE, Ehrlich R
Journal of cellular biochemistry 2004 Apr 15;91(6):1130-45
Journal of cellular biochemistry 2004 Apr 15;91(6):1130-45
T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.
Sanjuán MA, Pradet-Balade B, Jones DR, Martínez-A C, Stone JC, Garcia-Sanz JA, Mérida I
Journal of immunology (Baltimore, Md. : 1950) 2003 Mar 15;170(6):2877-83
Journal of immunology (Baltimore, Md. : 1950) 2003 Mar 15;170(6):2877-83
T cell activation in vivo targets diacylglycerol kinase alpha to the membrane: a novel mechanism for Ras attenuation.
Sanjuán MA, Pradet-Balade B, Jones DR, Martínez-A C, Stone JC, Garcia-Sanz JA, Mérida I
Journal of immunology (Baltimore, Md. : 1950) 2003 Mar 15;170(6):2877-83
Journal of immunology (Baltimore, Md. : 1950) 2003 Mar 15;170(6):2877-83
Amino acid composition of alpha1/alpha2 domains and cytoplasmic tail of MHC class I molecules determine their susceptibility to human cytomegalovirus US11-mediated down-regulation.
Barel MT, Pizzato N, van Leeuwen D, Bouteiller PL, Wiertz EJ, Lenfant F
European journal of immunology 2003 Jun;33(6):1707-16
European journal of immunology 2003 Jun;33(6):1707-16
Potent iron chelators increase the mRNA levels of the universal cyclin-dependent kinase inhibitor p21(CIP1/WAF1), but paradoxically inhibit its translation: a potential mechanism of cell cycle dysregulation.
Le NT, Richardson DR
Carcinogenesis 2003 Jun;24(6):1045-58
Carcinogenesis 2003 Jun;24(6):1045-58
Mammalian ykt6 is a neuronal SNARE targeted to a specialized compartment by its profilin-like amino terminal domain.
Hasegawa H, Zinsser S, Rhee Y, Vik-Mo EO, Davanger S, Hay JC
Molecular biology of the cell 2003 Feb;14(2):698-720
Molecular biology of the cell 2003 Feb;14(2):698-720
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Barel MT, Ressing M, Pizzato N, van Leeuwen D, Le Bouteiller P, Lenfant F, Wiertz EJ
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6757-65
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6757-65
Human cytomegalovirus-encoded US2 differentially affects surface expression of MHC class I locus products and targets membrane-bound, but not soluble HLA-G1 for degradation.
Barel MT, Ressing M, Pizzato N, van Leeuwen D, Le Bouteiller P, Lenfant F, Wiertz EJ
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6757-65
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6757-65
Lipid raft-associated protein sorting in exosomes.
de Gassart A, Geminard C, Fevrier B, Raposo G, Vidal M
Blood 2003 Dec 15;102(13):4336-44
Blood 2003 Dec 15;102(13):4336-44
The role of c-Src in platelet-derived growth factor alpha receptor internalization.
Avrov K, Kazlauskas A
Experimental cell research 2003 Dec 10;291(2):426-34
Experimental cell research 2003 Dec 10;291(2):426-34
Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions.
Burgueño J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F
Journal of neurochemistry 2003 Aug;86(4):785-91
Journal of neurochemistry 2003 Aug;86(4):785-91
Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions.
Burgueño J, Enrich C, Canela EI, Mallol J, Lluis C, Franco R, Ciruela F
Journal of neurochemistry 2003 Aug;86(4):785-91
Journal of neurochemistry 2003 Aug;86(4):785-91
Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.
Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, Kagawa S, Sasaki T
Biochemical and biophysical research communications 2003 Aug 22;308(2):270-5
Biochemical and biophysical research communications 2003 Aug 22;308(2):270-5
Distinct roles of Rab3B and Rab13 in the polarized transport of apical, basolateral, and tight junctional membrane proteins to the plasma membrane.
Yamamoto Y, Nishimura N, Morimoto S, Kitamura H, Manabe S, Kanayama HO, Kagawa S, Sasaki T
Biochemical and biophysical research communications 2003 Aug 22;308(2):270-5
Biochemical and biophysical research communications 2003 Aug 22;308(2):270-5
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.
Hering H, Lin CC, Sheng M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Apr 15;23(8):3262-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Apr 15;23(8):3262-71
Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability.
Hering H, Lin CC, Sheng M
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Apr 15;23(8):3262-71
The Journal of neuroscience : the official journal of the Society for Neuroscience 2003 Apr 15;23(8):3262-71
Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis.
Strick DJ, Francescutti DM, Zhao Y, Elferink LA
The Journal of biological chemistry 2002 Sep 6;277(36):32722-9
The Journal of biological chemistry 2002 Sep 6;277(36):32722-9
A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.
Vettermann C, Jäck HM, Mielenz D
Analytical biochemistry 2002 Sep 15;308(2):381-7
Analytical biochemistry 2002 Sep 15;308(2):381-7
A colloidal silver staining--destaining method for precise assignment of immunoreactive spots in two-dimensional protein patterns.
Vettermann C, Jäck HM, Mielenz D
Analytical biochemistry 2002 Sep 15;308(2):381-7
Analytical biochemistry 2002 Sep 15;308(2):381-7
Association of human transferrin receptor with GABARAP.
Green F, O'Hare T, Blackwell A, Enns CA
FEBS letters 2002 May 8;518(1-3):101-6
FEBS letters 2002 May 8;518(1-3):101-6
Association of human transferrin receptor with GABARAP.
Green F, O'Hare T, Blackwell A, Enns CA
FEBS letters 2002 May 8;518(1-3):101-6
FEBS letters 2002 May 8;518(1-3):101-6
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
Hu Y, Chuang JZ, Xu K, McGraw TG, Sung CH
Journal of cell science 2002 Dec 15;115(Pt 24):4755-63
Journal of cell science 2002 Dec 15;115(Pt 24):4755-63
SARA, a FYVE domain protein, affects Rab5-mediated endocytosis.
Hu Y, Chuang JZ, Xu K, McGraw TG, Sung CH
Journal of cell science 2002 Dec 15;115(Pt 24):4755-63
Journal of cell science 2002 Dec 15;115(Pt 24):4755-63
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain.
Traiffort E, Moya KL, Faure H, Hässig R, Ruat M
The European journal of neuroscience 2001 Sep;14(5):839-50
The European journal of neuroscience 2001 Sep;14(5):839-50
High expression and anterograde axonal transport of aminoterminal sonic hedgehog in the adult hamster brain.
Traiffort E, Moya KL, Faure H, Hässig R, Ruat M
The European journal of neuroscience 2001 Sep;14(5):839-50
The European journal of neuroscience 2001 Sep;14(5):839-50
Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling.
Bennett EM, Lin SX, Towler MC, Maxfield FR, Brodsky FM
Molecular biology of the cell 2001 Sep;12(9):2790-9
Molecular biology of the cell 2001 Sep;12(9):2790-9
Clathrin hub expression affects early endosome distribution with minimal impact on receptor sorting and recycling.
Bennett EM, Lin SX, Towler MC, Maxfield FR, Brodsky FM
Molecular biology of the cell 2001 Sep;12(9):2790-9
Molecular biology of the cell 2001 Sep;12(9):2790-9
Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.
Fonseca AM, Porto G, Uchida K, Arosa FA
Blood 2001 May 15;97(10):3152-60
Blood 2001 May 15;97(10):3152-60
Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.
Fonseca AM, Porto G, Uchida K, Arosa FA
Blood 2001 May 15;97(10):3152-60
Blood 2001 May 15;97(10):3152-60
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling.
Fraile-Ramos A, Kledal TN, Pelchen-Matthews A, Bowers K, Schwartz TW, Marsh M
Molecular biology of the cell 2001 Jun;12(6):1737-49
Molecular biology of the cell 2001 Jun;12(6):1737-49
The human cytomegalovirus US28 protein is located in endocytic vesicles and undergoes constitutive endocytosis and recycling.
Fraile-Ramos A, Kledal TN, Pelchen-Matthews A, Bowers K, Schwartz TW, Marsh M
Molecular biology of the cell 2001 Jun;12(6):1737-49
Molecular biology of the cell 2001 Jun;12(6):1737-49
Afipia felis induces uptake by macrophages directly into a nonendocytic compartment.
Luhrmann A, Streker K, Schüttfort A, Daniels JJ, Haas A
Proceedings of the National Academy of Sciences of the United States of America 2001 Jun 19;98(13):7271-6
Proceedings of the National Academy of Sciences of the United States of America 2001 Jun 19;98(13):7271-6
Antigen loading of MHC class I molecules in the endocytic tract.
Kleijmeer MJ, Escola JM, UytdeHaag FG, Jakobson E, Griffith JM, Osterhaus AD, Stoorvogel W, Melief CJ, Rabouille C, Geuze HJ
Traffic (Copenhagen, Denmark) 2001 Feb;2(2):124-37
Traffic (Copenhagen, Denmark) 2001 Feb;2(2):124-37
Antigen loading of MHC class I molecules in the endocytic tract.
Kleijmeer MJ, Escola JM, UytdeHaag FG, Jakobson E, Griffith JM, Osterhaus AD, Stoorvogel W, Melief CJ, Rabouille C, Geuze HJ
Traffic (Copenhagen, Denmark) 2001 Feb;2(2):124-37
Traffic (Copenhagen, Denmark) 2001 Feb;2(2):124-37
Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains.
Abrami L, Fivaz M, Kobayashi T, Kinoshita T, Parton RG, van der Goot FG
The Journal of biological chemistry 2001 Aug 17;276(33):30729-36
The Journal of biological chemistry 2001 Aug 17;276(33):30729-36
Canine and feline parvoviruses can use human or feline transferrin receptors to bind, enter, and infect cells.
Parker JS, Murphy WJ, Wang D, O'Brien SJ, Parrish CR
Journal of virology 2001 Apr;75(8):3896-902
Journal of virology 2001 Apr;75(8):3896-902
Rab15 differentially regulates early endocytic trafficking.
Zuk PA, Elferink LA
The Journal of biological chemistry 2000 Sep 1;275(35):26754-64
The Journal of biological chemistry 2000 Sep 1;275(35):26754-64
E3-13.7 integral membrane proteins encoded by human adenoviruses alter epidermal growth factor receptor trafficking by interacting directly with receptors in early endosomes.
Crooks D, Kil SJ, McCaffery JM, Carlin C
Molecular biology of the cell 2000 Oct;11(10):3559-72
Molecular biology of the cell 2000 Oct;11(10):3559-72
E3-13.7 integral membrane proteins encoded by human adenoviruses alter epidermal growth factor receptor trafficking by interacting directly with receptors in early endosomes.
Crooks D, Kil SJ, McCaffery JM, Carlin C
Molecular biology of the cell 2000 Oct;11(10):3559-72
Molecular biology of the cell 2000 Oct;11(10):3559-72
Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.
Hewett J, Gonzalez-Agosti C, Slater D, Ziefer P, Li S, Bergeron D, Jacoby DJ, Ozelius LJ, Ramesh V, Breakefield XO
Human molecular genetics 2000 May 22;9(9):1403-13
Human molecular genetics 2000 May 22;9(9):1403-13
Mutant torsinA, responsible for early-onset torsion dystonia, forms membrane inclusions in cultured neural cells.
Hewett J, Gonzalez-Agosti C, Slater D, Ziefer P, Li S, Bergeron D, Jacoby DJ, Ozelius LJ, Ramesh V, Breakefield XO
Human molecular genetics 2000 May 22;9(9):1403-13
Human molecular genetics 2000 May 22;9(9):1403-13
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.
Sönnichsen B, De Renzis S, Nielsen E, Rietdorf J, Zerial M
The Journal of cell biology 2000 May 15;149(4):901-14
The Journal of cell biology 2000 May 15;149(4):901-14
Distinct membrane domains on endosomes in the recycling pathway visualized by multicolor imaging of Rab4, Rab5, and Rab11.
Sönnichsen B, De Renzis S, Nielsen E, Rietdorf J, Zerial M
The Journal of cell biology 2000 May 15;149(4):901-14
The Journal of cell biology 2000 May 15;149(4):901-14
Brefeldin A-dependent membrane tubule formation reconstituted in vitro is driven by a cell cycle-regulated microtubule motor.
Robertson AM, Allan VJ
Molecular biology of the cell 2000 Mar;11(3):941-55
Molecular biology of the cell 2000 Mar;11(3):941-55
Brefeldin A-dependent membrane tubule formation reconstituted in vitro is driven by a cell cycle-regulated microtubule motor.
Robertson AM, Allan VJ
Molecular biology of the cell 2000 Mar;11(3):941-55
Molecular biology of the cell 2000 Mar;11(3):941-55
Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107.
Hagihara N, Walbridge S, Olson AW, Oldfield EH, Youle RJ
Cancer research 2000 Jan 15;60(2):230-4
Cancer research 2000 Jan 15;60(2):230-4
The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components.
Gagescu R, Demaurex N, Parton RG, Hunziker W, Huber LA, Gruenberg J
Molecular biology of the cell 2000 Aug;11(8):2775-91
Molecular biology of the cell 2000 Aug;11(8):2775-91
The recycling endosome of Madin-Darby canine kidney cells is a mildly acidic compartment rich in raft components.
Gagescu R, Demaurex N, Parton RG, Hunziker W, Huber LA, Gruenberg J
Molecular biology of the cell 2000 Aug;11(8):2775-91
Molecular biology of the cell 2000 Aug;11(8):2775-91
Palmitoylation of caveolin-1 is required for cholesterol binding, chaperone complex formation, and rapid transport of cholesterol to caveolae.
Uittenbogaard A, Smart EJ
The Journal of biological chemistry 2000 Aug 18;275(33):25595-9
The Journal of biological chemistry 2000 Aug 18;275(33):25595-9
High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae.
Uittenbogaard A, Shaul PW, Yuhanna IS, Blair A, Smart EJ
The Journal of biological chemistry 2000 Apr 14;275(15):11278-83
The Journal of biological chemistry 2000 Apr 14;275(15):11278-83
Development, characterization, and use of monoclonal antibodies made to antigens expressed on the surface of fetal nucleated red blood cells.
Alvarez FV, Olander J, Crimmins D, Prieto B, Paz A, Alonso R, Porter S, Hess J, Crist RD, Landt Y, Ladenson JH
Clinical chemistry 1999 Sep;45(9):1614-20
Clinical chemistry 1999 Sep;45(9):1614-20
Membrane trafficking regulates the activity of the human dopamine transporter.
Melikian HE, Buckley KM
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Sep 15;19(18):7699-710
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Sep 15;19(18):7699-710
Membrane trafficking regulates the activity of the human dopamine transporter.
Melikian HE, Buckley KM
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Sep 15;19(18):7699-710
The Journal of neuroscience : the official journal of the Society for Neuroscience 1999 Sep 15;19(18):7699-710
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
Wang X, Kibschull M, Laue MM, Lichte B, Petrasch-Parwez E, Kilimann MW
The Journal of cell biology 1999 Oct 4;147(1):151-62
The Journal of cell biology 1999 Oct 4;147(1):151-62
Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
Wang X, Kibschull M, Laue MM, Lichte B, Petrasch-Parwez E, Kilimann MW
The Journal of cell biology 1999 Oct 4;147(1):151-62
The Journal of cell biology 1999 Oct 4;147(1):151-62
Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle.
Gaschet J, Hsu VW
The Journal of biological chemistry 1999 Jul 9;274(28):20040-5
The Journal of biological chemistry 1999 Jul 9;274(28):20040-5
Distribution of ARF6 between membrane and cytosol is regulated by its GTPase cycle.
Gaschet J, Hsu VW
The Journal of biological chemistry 1999 Jul 9;274(28):20040-5
The Journal of biological chemistry 1999 Jul 9;274(28):20040-5
Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.
Attieh ZK, Mukhopadhyay CK, Seshadri V, Tripoulas NA, Fox PL
The Journal of biological chemistry 1999 Jan 8;274(2):1116-23
The Journal of biological chemistry 1999 Jan 8;274(2):1116-23
Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism.
Attieh ZK, Mukhopadhyay CK, Seshadri V, Tripoulas NA, Fox PL
The Journal of biological chemistry 1999 Jan 8;274(2):1116-23
The Journal of biological chemistry 1999 Jan 8;274(2):1116-23
Separation and partial characterization of three distinct intracellular GLUT4 compartments in rat adipocytes. Subcellular fractionation without homogenization.
Lee W, Ryu J, Souto RP, Pilch PF, Jung CY
The Journal of biological chemistry 1999 Dec 31;274(53):37755-62
The Journal of biological chemistry 1999 Dec 31;274(53):37755-62
Rab15 mediates an early endocytic event in Chinese hamster ovary cells.
Zuk PA, Elferink LA
The Journal of biological chemistry 1999 Aug 6;274(32):22303-12
The Journal of biological chemistry 1999 Aug 6;274(32):22303-12
Rab15 mediates an early endocytic event in Chinese hamster ovary cells.
Zuk PA, Elferink LA
The Journal of biological chemistry 1999 Aug 6;274(32):22303-12
The Journal of biological chemistry 1999 Aug 6;274(32):22303-12
KIF2beta, a new kinesin superfamily protein in non-neuronal cells, is associated with lysosomes and may be implicated in their centrifugal translocation.
Santama N, Krijnse-Locker J, Griffiths G, Noda Y, Hirokawa N, Dotti CG
The EMBO journal 1998 Oct 15;17(20):5855-67
The EMBO journal 1998 Oct 15;17(20):5855-67
The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Jul 15;18(14):5311-21
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Jul 15;18(14):5311-21
The neural cell adhesion molecule L1 interacts with the AP-2 adaptor and is endocytosed via the clathrin-mediated pathway.
Kamiguchi H, Long KE, Pendergast M, Schaefer AW, Rapoport I, Kirchhausen T, Lemmon V
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Jul 15;18(14):5311-21
The Journal of neuroscience : the official journal of the Society for Neuroscience 1998 Jul 15;18(14):5311-21
Transferrin and transferrin receptor in human hypophysis and pituitary adenomas.
Tampanaru-Sarmesiu A, Stefaneanu L, Thapar K, Kontogeorgos G, Sumi T, Kovacs K
The American journal of pathology 1998 Feb;152(2):413-22
The American journal of pathology 1998 Feb;152(2):413-22
Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.
Gross CN, Irrinki A, Feder JN, Enns CA
The Journal of biological chemistry 1998 Aug 21;273(34):22068-74
The Journal of biological chemistry 1998 Aug 21;273(34):22068-74
Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation.
Gross CN, Irrinki A, Feder JN, Enns CA
The Journal of biological chemistry 1998 Aug 21;273(34):22068-74
The Journal of biological chemistry 1998 Aug 21;273(34):22068-74
Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN.
Le Borgne R, Hoflack B
The Journal of cell biology 1997 Apr 21;137(2):335-45
The Journal of cell biology 1997 Apr 21;137(2):335-45
Mannose 6-phosphate receptors regulate the formation of clathrin-coated vesicles in the TGN.
Le Borgne R, Hoflack B
The Journal of cell biology 1997 Apr 21;137(2):335-45
The Journal of cell biology 1997 Apr 21;137(2):335-45
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Supportive validation
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- Knockdown of Transferrin Receptor was achieved by transfecting HeLa cells with Transferrin Receptor specific validated siRNAs (Silencer® select Product # s725). Western blot analysis (Fig 1) was performed using whole cell extracts from the Transferrin Receptor knockdown cells (lane 3), non-specific scrambled siRNA transfected cells (lane 2) and untransfected cells (lane 1). The blots were probed with Anti-Transferrin Receptor Antibody, Mouse monoclonal (Product # 13-6800, 1 µg/mL) and Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.4 µg/mL, 1:4000 dilution). Densitometric analysis of this western blot is shown in histogram (Fig 2). Decrease in signal upon siRNA mediated knock down confirms that antibody is specific to Transferrin Receptor.
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- Western blot analysis was performed on whole cell extracts (30 µg lysate) of HeLa (Lane 1), HL-60 (Lane 2), HEL 92.1.7 (Lane 3), K-562 (Lane 4), PC-3 (Lane 5), LNCaP (Lane 6), DU 145 (Lane 7), MCF7 (Lane 8), MDA-MB-231 (Lane 9) and T-47D (Lane 10). The blot was probed with Anti-Transferrin Receptor Mouse Monoclonal Antibody (Product # 13-6800, 2 µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal Secondary Antibody, HRP conjugate (Product # A28177, 0.4 µg/mL, 1:2500 dilution). A 90 kDa band corresponding to Transferrin Receptor was observed across the cell lines tested. Known quantity of protein samples were electrophoresed using Novex®NuPAGE®4-12 % Bis-Tris gel (Product # NP0321BOX), XCell SureLock Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
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- Knockout of Transferrin Receptor was achieved by CRISPR-Cas9 genome editing using LentiArray™ Lentiviral sgRNA (Product # A32042, Assay ID CRISPR944258_LV) and LentiArray Cas9 Lentivirus (Product # A32064). Western blot analysis of Transferrin Receptor was performed by loading 30 µg of HeLa Wild Type (Lane 1), HeLa Cas9 (Lane 2) andHeLa Transferrin Receptor KO (Lane 3) whole cell extracts. The samples were electrophoresed using NuPAGE™ Novex™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBlot® 2 Dry Blotting System (Product # IB21001). The blot was probed with Anti-Transferrin Receptor Monoclonal Antibody (H68.4) (Product # 13-6800, 0.5 µg/mL dilution) and Goat anti-Mouse IgG (H+L) Superclonal™ Recombinant Secondary Antibody, HRP (Product # A28177, 1:5,000 dilution) using the iBright FL 1000 (Product # A32752). Chemiluminescent detection was performed using Novex® ECL Chemiluminescent Substrate Reagent Kit (Product # WP20005). Loss of signal upon CRISPR mediated knockout (KO) using the LentiArray™ CRISPR product line confirms that antibody is specific to Transferrin Receptor.
Supportive validation
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- Immunofluorescence analysis of Transferrin Receptor Monoclonal Antibody (H68.4) was performed using 70% confluent log phase MCF-7 cells. The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton X-100 for 10 minutes, and blocked with 1% BSA for 1 hour at room temperature. The cells were labeled with Transferrin Receptor (H68.4) Mouse Monoclonal Antibody (Product # 13-6800) at 1:250 dilution in 0.1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: red) was stained with Rhodamine Phalloidin (Product # R415, 1:300). Panel d represents the merged image showing cytoplasmic localization. Panel e shows the no primary antibody control. The images were captured at 60X magnification.
Supportive validation
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- Figure 3 Quantitation of expression levels of less tumor specific markers using immunofluorescence. Expression levels of less tumor-specific membrane markers (CD44v6, MUC1, Mammaglobin, and CAXII) as determined by immunofluorescence resulted in staining patterns in normal breast epithelium and positive tumors comparable to conventional immunohistochemistry (Transferrin Receptor was not detectable). Size bar equals 25 mum.
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- Figure 3 Cells infected with C. burnetii exhibit more internalized Tf . (A) HeLa cells infected with C. burnetii or left uninfected were incubated with Tf488 for the indicated times. CellProfiler was used to select only cells that emitted strong C. burnetii signal (Infected--large PV) from the total population of cells in infected cell cultures (Infected). The amount of intracellular Tf was measured by quantitative fluorescence microscopy. Plots depict percent Tf488 intensity calculated relative to uninfected cell cultures (Uninfected) at 0 min. A black asterisk indicates the mean Tf intensity of infected cell cultures is significantly greater than for uninfected cell cultures. A green asterisk indicates the mean Tf intensities of the subset of cells containing large PV is significantly greater than for infected or uninfected cell cultures. Statistical significance ( P < 0.01) was determined by two-way ANOVA using Tukey's test for multiple comparisons with the mean number of cells counted per sample equal to 1038 +- 411. (B) Similar slopes were detected in the linear first 5 min of the Tf endocytosis assay, indicating increased internalized Tf by infected cells is not due to an increase in the rate of uptake (3 days post-infection). The plot depicts mean Tf488 signal intensity (integrated intensity per cell) with the mean number of cells counted at each time point equal to 1553 +- 178. (C) Increased internalized Tf by infected cells (total population) is not a
