TMEM158

Constitutive activation of the Ras pathway triggers an irreversible proliferation arrest reminiscent of replicative senescence. Transcription of this gene is upregulated in response to activation of the Ras pathway, but not under other conditions that induce senescence. The encoded protein is similar to a rat cell surface receptor proposed to function in a neuronal survival pathway. An allelic polymorphism in this gene results in both functional and non-functional (frameshifted) alleles; the reference genome represents the functional allele. [provided by RefSeq, Jul 2015]

Description

Transmembrane protein 158

Tissue specificity

Tissue enhanced (brain, endometrium)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

3 (45224466 - 45226287)

Ensembl ID

ENSG00000249992  (ver. 103.38)

Orthologs

Mouse Tmem158: ENSMUSG00000054871

UniProt

Q8WZ71

neXtProt

NX_Q8WZ71

Human splice variants
Mouse splice variants

Protein structure