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Protein structure
LRP5
LDL receptor related protein 5BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPS, OPTA1, VBCH2
This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Top validated antibodies |
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| Novus Biologicals |  H00004041-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
FC
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| Proteintech Group | 24899-1-AP |
3 references | Polyclonal |
WB
EL
ICC
IHC
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| Invitrogen Antibodies | 36-5400 |
6 references | Polyclonal |
WB
ICC
OA
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| antibodies-online | ABIN969535 |
2 references | Monoclonal |
WB
EL
FC
|
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| LSBio | LS-C482233 |
Polyclonal |
WB
IHC
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