CD3D

The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]

Description

CD3d molecule

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Endoplasmic reticulum

Predicted location

Intracellular, Membrane

Protein family

CD markers
Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11 (118339075 - 118342705)

Ensembl ID

ENSG00000167286  (ver. 103.38)

Orthologs

Mouse Cd3d: ENSMUSG00000032094

UniProt

P04234

neXtProt

NX_P04234

Human splice variants
Mouse splice variants

Protein structure