TM4SF20

The protein encoded by this gene is a member of the four-transmembrane L6 superfamily. Members of this family function in various cellular processes including cell proliferation, motility, and adhesion via their interactions with integrins. In human brain tissue, this gene is expressed at high levels in the parietal lobe, occipital lobe, hippocampus, pons, white matter, corpus callosum, and cerebellum. Knockout of the homologous gene in mouse results in a neurobehavioral phenotype with suggested enhanced motor coordination. A deletion mutation in the human gene is associated with specific language impairment-5. [provided by RefSeq, Jul 2016]

Description

Transmembrane 4 L six family member 20

Tissue specificity

Tissue enriched (intestine)

Subcell location

Plasma membrane, Focal adhesion sites

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Chromosome

2 (227362038 - 227381995)

Ensembl ID

ENSG00000168955  (ver. 103.38)

Orthologs

Mouse Tm4sf20: ENSMUSG00000026149

UniProt

Q53R12

neXtProt

NX_Q53R12

Human splice variants
Mouse splice variants

Protein structure