SPTBN4

Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. This gene is one member of a family of beta-spectrin genes. The encoded protein localizes to the nuclear matrix, PML nuclear bodies, and cytoplasmic vesicles. A highly similar gene in the mouse is required for localization of specific membrane proteins in polarized regions of neurons. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Spectrin beta, non-erythrocytic 4

Tissue specificity

Group enriched (brain, pituitary gland)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (40466241 - 40576464)

Ensembl ID

ENSG00000160460  (ver. 103.38)

Orthologs

Mouse Sptbn4: ENSMUSG00000011751

UniProt

Q9H254

neXtProt

NX_Q9H254

Human splice variants
Mouse splice variants

Protein structure