DDR1

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]

Description

Discoidin domain receptor tyrosine kinase 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cell Junctions

Predicted location

Intracellular, Membrane

Protein family

CD markers
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (30876421 - 30900156)

Ensembl ID

ENSG00000204580  (ver. 103.38)

Orthologs

Mouse Ddr1: ENSMUSG00000003534

UniProt

Q08345

neXtProt

NX_Q08345

Human splice variants
Mouse splice variants

Protein structure