BS9238

antibody from Bioworld Technology, Inc
Targeting: DDR1 CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6
Provider product page for BS9238

Antibody data

Product number
BS9238 - Provider product page
Provider
Bioworld Technology, Inc
Product name
DDR1 (R798) polyclonal antibody
Antibody type
Polyclonal
Antigen
Synthetic peptide, corresponding to amino acids 770-820 of Human DDR1.
Description
The majority of the large number of receptor tyrosine kinases that have been identified can be categorized into distinct families based on the structure of their extracellular domains. Only a limited number of ligands for the receptors have been described, and while the majority of the ligands identified are soluble factors, an increasing number of receptors have been shown to bind to cell-surface molecules. Discoidin domain receptor 1 (DDR1), previously identified as Cak, for cell adhesion kinase (and also designated MCK-10, EDDR1, NEP, Ptk-3, RTK6, trk E or NTRK4) and discoidin domain receptor 2 (DDR2) comprise a new family of receptor tyrosine kinases involved in cell-cell interactions. Both DDR1 and DDR2 have been shown to be activated by collagen. Evidence suggests that a docking site for the Shc phosphotyrosine binding domain is phosphorylated in response to activation of DDR1 by collagen, whereas collagen activation of DDR2 results in upregulation of matrix metalloproteinase-1 expression.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
DDR1 protein structure - BS9238 shown in red.