ATP4A

The protein encoded by this gene belongs to a family of P-type cation-transporting ATPases. The gastric H+, K+-ATPase is a heterodimer consisting of a high molecular weight catalytic alpha subunit and a smaller but heavily glycosylated beta subunit. This enzyme is a proton pump that catalyzes the hydrolysis of ATP coupled with the exchange of H(+) and K(+) ions across the plasma membrane. It is also responsible for gastric acid secretion. This gene encodes a catalytic alpha subunit of the gastric H+, K+-ATPase. [provided by RefSeq, Jul 2008]

Description

ATPase H+/K+ transporting subunit alpha

Tissue specificity

Tissue enriched (stomach)

Predicted location

Membrane

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

19 (35550031 - 35563658)

Ensembl ID

ENSG00000105675  (ver. 103.38)

Orthologs

Mouse Atp4a: ENSMUSG00000005553

UniProt

P20648

neXtProt

NX_P20648

Human splice variants
Mouse splice variants

Protein structure