HOXA10

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor that may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment. Alternatively spliced transcript variants have been described. Read-through transcription also exists between this gene and the downstream homeobox A9 (HOXA9) gene. [provided by RefSeq, Mar 2011]

Description

Homeobox A10

Tissue specificity

Tissue enhanced (endometrium , skeletal muscle)

Subcell location

Nucleoplasm, Nuclear bodies

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

7 (27170592 - 27180261)

Ensembl ID

ENSG00000253293  (ver. 103.38)

Orthologs

Mouse Hoxa10: ENSMUSG00000000938

UniProt

P31260

neXtProt

NX_P31260

Human splice variants
Mouse splice variants

Protein structure