SEMA3C

This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease. [provided by RefSeq, May 2017]

Description

Semaphorin 3C

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus, Plasma membrane, Cytosol

Predicted location

Secreted in other tissues

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

7 (80742538 - 80922359)

Ensembl ID

ENSG00000075223  (ver. 103.38)

Orthologs

Mouse Sema3c: ENSMUSG00000028780

UniProt

Q99985

neXtProt

NX_Q99985

Human splice variants
Mouse splice variants

Protein structure