SALL3

This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]

Description

Spalt like transcription factor 3

Tissue specificity

Tissue enhanced (brain, prostate, vagina)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transcription factors

Chromosome

18 (78980275 - 79002677)

Ensembl ID

ENSG00000256463  (ver. 103.38)

Orthologs

Mouse Sall3: ENSMUSG00000024565

UniProt

Q9BXA9

neXtProt

NX_Q9BXA9

Human splice variants
Mouse splice variants

Protein structure