BCDIN3D

This gene encodes an RNA methyltransferase which belongs to the rossmann fold methyltransferase family, and serves as a 5'-methylphosphate capping enzyme that is specific for cytoplasmic histidyl tRNA. The encoded protein contains an S-adenosylmethionine binding domain and uses the methyl group donor, S-adenosylmethionine. This gene is overexpressed in breast cancer cells, and is related to the tumorigenic phenotype and poor prognosis of breast cancer. The encoded protein is thought to promote the cellular invasion of breast cancer cells, by downregulating the expression of tumor suppressor miRNAs through the dimethylation of the 5-monophosphate of the corresponding precursor miRNAs. [provided by RefSeq, Apr 2017]

Description

BCDIN3 domain containing RNA methyltransferase

Tissue specificity

Tissue enhanced (skeletal muscle)

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

12 (49836043 - 49843106)

Ensembl ID

ENSG00000186666  (ver. 103.38)

Orthologs

Mouse Bcdin3d: ENSMUSG00000037525

UniProt

Q7Z5W3

neXtProt

NX_Q7Z5W3

Human splice variants
Mouse splice variants

Protein structure