GABRG3

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]

Description

Gamma-aminobutyric acid type A receptor subunit gamma3

Tissue specificity

Tissue enhanced (brain, retina, testis)

Predicted location

Intracellular, Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

15 (26971181 - 27541984)

Ensembl ID

ENSG00000182256  (ver. 103.38)

Orthologs

Mouse Gabrg3: ENSMUSG00000055026

UniProt

Q99928

neXtProt

NX_Q99928

Human splice variants
Mouse splice variants

Protein structure