OTOA

The protein encoded by this gene is specifically expressed in the inner ear, and is located at the interface between the apical surface of the inner ear sensory epithelia and their overlying acellular gels. It is prposed that this protein is involved in the attachment of the inner ear acellular gels to the apical surface of the underlying nonsensory cells. Mutations in this gene are associated with autosomal recessive deafness type 22 (DFNB22). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Description

Otoancorin

Tissue specificity

Group enriched (lymphoid tissue, testis)

Predicted location

Intracellular, Secreted in other tissues

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Kim et al 2014)

Chromosome

16 (21663968 - 21761935)

Ensembl ID

ENSG00000155719  (ver. 103.38)

Orthologs

Mouse Otoa: ENSMUSG00000034990

UniProt

Q7RTW8

neXtProt

NX_Q7RTW8

Human splice variants
Mouse splice variants

Protein structure