FBXO45

Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]). [supplied by OMIM, Jan 2011]

Description

F-box protein 45

Tissue specificity

Low tissue specificity

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (196568611 - 196589059)

Ensembl ID

ENSG00000174013  (ver. 103.38)

Orthologs

Mouse Fbxo45: ENSMUSG00000035764

UniProt

P0C2W1

neXtProt

NX_P0C2W1

Human splice variants
Mouse splice variants

Protein structure