KCNE5

This gene encodes a member of a family of single pass transmembrane domain proteins that function as ancillary subunits to voltage-gated potassium channels. Members of this family affect diverse processes in potassium channel regulation, including ion selectivity, voltage dependence, and anterograde recycling from the plasma membrane. Variants of this gene are associated with idiopathic ventricular fibrillation and Brugada syndrome. [provided by RefSeq, Nov 2016]

Description

Potassium voltage-gated channel subfamily E regulatory subunit 5

Tissue specificity

Tissue enhanced (brain, skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Membrane

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted membrane proteins
Transporters

Chromosome

X (109623700 - 109625172)

Ensembl ID

ENSG00000176076  (ver. 103.38)

Orthologs

Mouse Kcne1l: ENSMUSG00000090122

UniProt

Q9UJ90

neXtProt

NX_Q9UJ90

Human splice variants
Mouse splice variants

Protein structure