FLVCR2

This gene encodes a member of the major facilitator superfamily. The encoded transmembrane protein is a calcium transporter. Unlike the related protein feline leukemia virus subgroup C receptor 1, the protein encoded by this locus does not bind to feline leukemia virus subgroup C envelope protein. The encoded protein may play a role in development of brain vascular endothelial cells, as mutations at this locus have been associated with proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]

Description

FLVCR heme transporter 2

Tissue specificity

Low tissue specificity

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

14 (75578620 - 75663214)

Ensembl ID

ENSG00000119686  (ver. 103.38)

Orthologs

Mouse Flvcr2: ENSMUSG00000034258

UniProt

Q9UPI3

neXtProt

NX_Q9UPI3

Human splice variants
Mouse splice variants

Protein structure