ARHGAP11A

This gene encodes a member of the Rho GTPase activating protein family. In response to DNA damage, the encoded protein interacts with the p53 tumor suppressor protein and stimulates its tetramerization, which results in cell-cycle arrest and apoptosis. A chromosomal deletion that includes this gene is one cause of Prader-Willi syndrome, and an intronic variant of this gene may be associated with sleep duration in children. This gene is highly expressed in colon cancers and in a human basal-like breast cancer cell line. This gene also produces a ARHGAP11A-SCG5 readthrough transcript and ARHGAP11A-SCG5 protein. [provided by RefSeq, Feb 2019]

Description

Rho GTPase activating protein 11A

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Nucleoli, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

15 (32615144 - 32639941)

Ensembl ID

ENSG00000198826  (ver. 103.38)

Orthologs

-

UniProt

Q6P4F7

neXtProt

NX_Q6P4F7

Human splice variants

Protein structure