MMP24

This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. Unlike most MMPs, which are secreted, this protease is a member of the membrane-type MMP (MT-MMP) subfamily, contains a transmembrane domain and is expressed at the cell surface. Substrates of this protease include the proteins cadherin 2 and matrix metallopeptidase 2 (also known as 72 kDa type IV collagenase). The gene has previously been referred to as MMP25 but has been renamed matrix metallopeptidase 24 (MMP24). [provided by RefSeq, Oct 2019]

Description

Matrix metallopeptidase 24

Tissue specificity

Tissue enriched (brain)

Subcell location

Nucleoli, Plasma membrane

Predicted location

Membrane, Secreted to extracellular matrix

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Predicted secreted proteins

Chromosome

20 (35226690 - 35276998)

Ensembl ID

ENSG00000125966  (ver. 103.38)

Orthologs

Mouse Mmp24: ENSMUSG00000027612

UniProt

Q9Y5R2

neXtProt

NX_Q9Y5R2

Human splice variants
Mouse splice variants

Protein structure