ABI3

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain, and are components of the Abi/WAVE complex which regulates actin polymerization. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Description

ABI family member 3

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

17 (49210411 - 49223225)

Ensembl ID

ENSG00000108798  (ver. 103.38)

Orthologs

Mouse Abi3: ENSMUSG00000018381

UniProt

Q9P2A4

neXtProt

NX_Q9P2A4

Human splice variants
Mouse splice variants

Protein structure