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NEDD4L
NEDD4 like E3 ubiquitin protein ligaseKIAA0439, NEDD4-2, RSP5
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Top validated antibodies |
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| Proteintech Group |  13690-1-AP |
15 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| Boster Biological Technology | A01595-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Invitrogen Antibodies | H00023327-M04 |
Monoclonal |
WB
EL
IP
OA
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| Biorbyt | orb402251 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| NovoPro Bioscience Inc. | 113097 |
Polyclonal |
WB
EL
ICC
IHC
|
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