RASAL3

This gene belongs to the Ras GTPase-activating proteins (RasGAP) family and encodes a protein with pleckstrin homology (PH), C2, and Ras GTPase-activation protein (RasGAP) domains. This protein is localized near or at the plasma membrane when expressed exogenously. Reduced expression of this gene in some cell lines resulted in increased levels of the active form of Ras (Ras-GTP), suggesting that this gene may play a role in negatively regulating the Ras signaling pathway. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]

Description

RAS protein activator like 3

Tissue specificity

Group enriched (bone marrow, intestine, lung, lymphoid tissue)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

19 (15451624 - 15464544)

Ensembl ID

ENSG00000105122  (ver. 103.38)

Orthologs

Mouse Rasal3: ENSMUSG00000052142

UniProt

Q86YV0

neXtProt

NX_Q86YV0

Human splice variants
Mouse splice variants

Protein structure