DUSP2

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1 and ERK2, is predominantly expressed in hematopoietic tissues, and is localized in the nucleus. [provided by RefSeq, Jul 2008]

Description

Dual specificity phosphatase 2

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm, Nuclear membrane

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

2 (96143169 - 96145440)

Ensembl ID

ENSG00000158050  (ver. 103.38)

Orthologs

Mouse Dusp2: ENSMUSG00000027368

UniProt

Q05923

neXtProt

NX_Q05923

Human splice variants
Mouse splice variants

Protein structure