60110.1

IL3RA antibody from STEMCELL Technologies Inc
CD123
Immunocytochemistry
Recommended by provider
Immunohistochemistry
Recommended by provider
Flow cytometry
Recommended by provider

Antibody data

Product number
60110.1
Provider
STEMCELL Technologies Inc
Product name
Anti-Human CD123 (IL-3R?) Antibody, Clone 6H6
Provider product page
STEMCELL Technologies Inc - 60110.1
Antibody type
Monoclonal
Description
The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit ?), an ~70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily. CD123 constitutes the ligand-binding ? chain of the heterodimeric IL-3 receptor. CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing ? chain of the receptor), high-affinity binding of IL-3 is observed. CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells. CD123 is highly expressed in malignancies such as acute leukemia. The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor.
Reactivity
Human
Isotype
IgG
Vial size
25 µg
Storage
2 - 8°C
Provider Type Product Number
- No reagents -