60110.1

antibody from STEMCELL Technologies Inc

Targeting: IL3RA CD123

Immunocytochemistry (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Recommended by provider)

Antibody Data

Product number

60110.1

Provider

STEMCELL Technologies Inc

Product name

Anti-Human CD123 (IL-3R?) Antibody, Clone 6H6

Antibody type

Monoclonal

Description

The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit ?), an ~70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily. CD123 constitutes the ligand-binding ? chain of the heterodimeric IL-3 receptor. CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing ? chain of the receptor), high-affinity binding of IL-3 is observed. CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF). IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells. CD123 is highly expressed in malignancies such as acute leukemia. The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor.

Reactivity

Human

Isotype

IgG

Vial size

25 µg

Storage

2 - 8°C