CORT

This gene encodes a neuropeptide that is structurally similar to somatostatin. It binds to all known somatostatin receptors, and shares many pharmacological and functional properties with somatostatin, including the depression of neuronal activity. However, it also has many properties distinct from somatostatin, such as induction of slow-wave sleep, apparently by antagonism of the excitatory effects of acetylcholine on the cortex, reduction of locomotor activity, and activation of cation selective currents not responsive to somatostatin. The preproprotein undergoes further processing into multiple mature products. Read-through transcripts exist between this gene and the upstream APITD1 (apoptosis-inducing, TAF9-like domain 1) gene, as represented in GeneID:100526739. [provided by RefSeq, Nov 2010]

Description

Cortistatin

Tissue specificity

Tissue enriched (brain)

Predicted location

Secreted in brain

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins

Chromosome

1 (10450031 - 10451998)

Ensembl ID

ENSG00000241563  (ver. 103.38)

Orthologs

Mouse Cort: ENSMUSG00000028971

UniProt

O00230

neXtProt

NX_O00230

Human splice variants
Mouse splice variants

Protein structure