RIPPLY2

This gene encodes a nuclear protein that belongs to a novel family of proteins required for vertebrate somitogenesis. Members of this family have a tetrapeptide WRPW motif that is required for interaction with the transcriptional repressor Groucho and a carboxy-terminal Ripply homology domain/Bowline-DSCR-Ledgerline conserved region required for transcriptional repression. Null mutant mice die soon after birth and display defects in axial skeleton segmentation due to defective somitogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

Description

Ripply transcriptional repressor 2

Tissue specificity

Tissue enhanced (brain, choroid plexus, pituitary gland)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

6 (83853266 - 83857515)

Ensembl ID

ENSG00000203877  (ver. 103.38)

Orthologs

Mouse Ripply2: ENSMUSG00000047897

UniProt

Q5TAB7

neXtProt

NX_Q5TAB7

Human splice variants
Mouse splice variants

Protein structure