KCNU1

This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Description

Potassium calcium-activated channel subfamily U member 1

Tissue specificity

Tissue enriched (testis)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

8 (36784324 - 36936125)

Ensembl ID

ENSG00000215262  (ver. 103.38)

Orthologs

Mouse Kcnu1: ENSMUSG00000031576

UniProt

A8MYU2

neXtProt

NX_A8MYU2

Human splice variants
Mouse splice variants

Protein structure