TUBA3E

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. This gene encodes an alpha tubulin that highly conserved among species. A missense mutation in this gene has been potentially linked to microlissencephaly and global developmental delay. [provided by RefSeq, Jul 2016]

Description

Tubulin alpha 3e

Tissue specificity

Tissue enriched (testis)

Subcell location

Microtubules

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

2 (130191745 - 130198439)

Ensembl ID

ENSG00000152086  (ver. 103.38)

Orthologs

-

UniProt

Q6PEY2

neXtProt

NX_Q6PEY2

Human splice variants

Protein structure