AF3628

antibody from Novus Biologicals

Targeting: PECAM1 CD31

Provider product page for AF3628

Western blot

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [90]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]
Flow cytometry [2]

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Product number: AF3628 - Provider product page
Provider: Novus Biologicals
Product name: Goat Polyclonal CD31/PECAM-1 Antibody
Antibody type: Polyclonal
Description: Antigen Affinity-purified. Detects mouse CD31/PECAM-1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human CD31 and recombinant porcine CD31 is observed. Detects mouse CD31 and rat CD31 in flow cytometry.
Reactivity: Mouse, Rat
Host: Goat
Conjugate: Unconjugated
Isotype: IgG
Vial size: 100 ug
Concentration: LYOPH
Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 6 months, -20 to -70 degreesC under sterile conditions after reconstitution.

PECAM1 protein structure - AF3628 shown in red.

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Molecular therapy : the journal of the American Society of Gene Therapy 2019 Dec 4;27(12):2134-2146

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Scientific reports 2019 Dec 20;9(1):19560

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Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier.

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Wnt/β-catenin signaling regulates VE-cadherin-mediated anastomosis of brain capillaries by counteracting S1pr1 signaling.

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A Bayesian Framework for Generalized Linear Mixed Modeling Identifies New Candidate Loci for Late-Onset Alzheimer's Disease.

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Mesenchymal stem cells attenuate blood-brain barrier leakage after cerebral ischemia in mice.

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cxcl12-engineered endothelial progenitor cells enhance neurogenesis and angiogenesis after ischemic brain injury in mice.

Li Y, Chang S, Li W, Tang G, Ma Y, Liu Y, Yuan F, Zhang Z, Yang GY, Wang Y
Stem cell research & therapy 2018 May 11;9(1):139

Gellan Gum-based luminal fillers for peripheral nerve regeneration: an in vivo study in the rat sciatic nerve repair model.

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KSHV-induced ligand mediated activation of PDGF receptor-alpha drives Kaposi's sarcomagenesis.

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Syndecan-1 induction in lung microenvironment supports the establishment of breast tumor metastases.

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Breast cancer research : BCR 2018 Jul 5;20(1):66

Characterization of multi-cellular dynamics of angiogenesis and vascular remodelling by intravital imaging of the wounded mouse cornea.

Wang Y, Jin Y, Laviña B, Jakobsson L
Scientific reports 2018 Jul 13;8(1):10672

Multicolor quantitative confocal imaging cytometry.

Coutu DL, Kokkaliaris KD, Kunz L, Schroeder T
Nature methods 2018 Jan;15(1):39-46

Type I interferons instigate fetal demise after Zika virus infection.

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Hindlimb Ischemia Impairs Endothelial Recovery and Increases Neointimal Proliferation in the Carotid Artery.

Sorrentino S, Iaconetti C, De Rosa S, Polimeni A, Sabatino J, Gareri C, Passafaro F, Mancuso T, Tammè L, Mignogna C, Camastra C, Esposito G, Curcio A, Torella D, Indolfi C
Scientific reports 2018 Jan 15;8(1):761

Bones in human CYP26B1 deficiency and rats with hypervitaminosis A phenocopy Vegfa overexpression.

Lind T, Lugano R, Gustafson AM, Norgård M, van Haeringen A, Dimberg A, Melhus H, Robertson SP, Andersson G
Bone reports 2018 Dec;9:27-36

Pancreatic Cell Fate Determination Relies on Notch Ligand Trafficking by NFIA.

Scavuzzo MA, Chmielowiec J, Yang D, Wamble K, Chaboub LS, Duraine L, Tepe B, Glasgow SM, Arenkiel BR, Brou C, Deneen B, Borowiak M
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SCL/TAL1 cooperates with Polycomb RYBP-PRC1 to suppress alternative lineages in blood-fated cells.

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Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy.

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The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.

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Nature communications 2018 Aug 14;9(1):3259

Resident Arterial Cells and Circulating Bone Marrow-Derived Cells both Contribute to Intimal Hyperplasia in a Rat Allograft Carotid Transplantation Model.

He Y, Xu X, Zhu T, Tang M, Mei J, Si Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;42(4):1303-1312

Excessive dietary intake of vitamin A reduces skull bone thickness in mice.

Lind T, Öhman C, Calounova G, Rasmusson A, Andersson G, Pejler G, Melhus H
PloS one 2017;12(4):e0176217

Clearance of Heparan Sulfate and Attenuation of CNS Pathology by Intracerebroventricular BMN 250 in Sanfilippo Type B Mice.

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Molecular therapy. Methods & clinical development 2017 Sep 15;6:43-53

Pericyte-targeting prodrug overcomes tumor resistance to vascular disrupting agents.

Chen M, Lei X, Shi C, Huang M, Li X, Wu B, Li Z, Han W, Du B, Hu J, Nie Q, Mai W, Ma N, Xu N, Zhang X, Fan C, Hong A, Xia M, Luo L, Ma A, Li H, Yu Q, Chen H, Zhang D, Ye W
The Journal of clinical investigation 2017 Oct 2;127(10):3689-3701

Natural compound bavachalcone promotes the differentiation of endothelial progenitor cells and neovascularization through the RORα-erythropoietin-AMPK axis.

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Oncotarget 2017 Oct 17;8(49):86188-86205

Brachyury drives formation of a distinct vascular branchpoint critical for fetal-placental arterial union in the mouse gastrula.

Rodriguez AM, Jin DX, Wolfe AD, Mikedis MM, Wierenga L, Hashmi MP, Viebahn C, Downs KM
Developmental biology 2017 May 15;425(2):208-222

Impacts of femoral artery and vein excision versus femoral artery excision on the hindlimb ischemic model in CD-1 mice.

Chen M, Fan H, Ledford BT, Farah Z, Barron C, Liu Z, He JQ
Microvascular research 2017 Mar;110:48-55

Gene therapy for a mouse model of glucose transporter-1 deficiency syndrome.

Nakamura S, Osaka H, Muramatsu SI, Takino N, Ito M, Aoki S, Jimbo EF, Shimazaki K, Onaka T, Ohtsuki S, Terasaki T, Yamagata T
Molecular genetics and metabolism reports 2017 Mar;10:67-74

Immunofluorescence reveals unusual patterns of labelling for connexin43 localized to calbindin-D28K-positive interstitial cells in the pineal gland.

Tsao DD, Wang SG, Lynn BD, Nagy JI
The European journal of neuroscience 2017 Jun;45(12):1553-1569

Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF
Nature cell biology 2017 Jun;19(6):653-665

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling.

Jin Y, Muhl L, Burmakin M, Wang Y, Duchez AC, Betsholtz C, Arthur HM, Jakobsson L
Nature cell biology 2017 Jun;19(6):639-652

Silencing of galectin-1 inhibits retinal neovascularization and ameliorates retinal hypoxia in a murine model of oxygen-induced ischemic retinopathy.

Yang N, Zhang W, He T, Xing Y
Experimental eye research 2017 Jun;159:1-15

Coronary angiogenic effect of long-term administration of Nigella sativa.

Al Asoom LI
BMC complementary and alternative medicine 2017 Jun 13;17(1):308

Gli1(+) Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R
Cell stem cell 2017 Jun 1;20(6):785-800.e8

Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development.

Gerl K, Steppan D, Fuchs M, Wagner C, Willam C, Kurtz A, Kurt B
The American journal of pathology 2017 Jul;187(7):1496-1511

Murine liver-resident group 1 innate lymphoid cells regulate optimal priming of anti-viral CD8+ T cells.

Krueger PD, Narayanan S, Surette FA, Brown MG, Sung SJ, Hahn YS
Journal of leukocyte biology 2017 Jan;101(1):329-338

TLR2-mediated leukocyte trafficking to the developing brain.

Mottahedin A, Smith PL, Hagberg H, Ek CJ, Mallard C
Journal of leukocyte biology 2017 Jan;101(1):297-305

Integrin β1 controls VE-cadherin localization and blood vessel stability.

Yamamoto H, Ehling M, Kato K, Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH
Nature communications 2015 Mar 10;6:6429

The formyl peptide receptor 1 exerts a tumor suppressor function in human gastric cancer by inhibiting angiogenesis.

Prevete N, Liotti F, Visciano C, Marone G, Melillo RM, de Paulis A
Oncogene 2015 Jul;34(29):3826-38

The transcription factor Mesp1 interacts with cAMP-responsive element binding protein 1 (Creb1) and coactivates Ets variant 2 (Etv2) gene expression.

Shi X, Zirbes KM, Rasmussen TL, Ferdous A, Garry MG, Koyano-Nakagawa N, Garry DJ
The Journal of biological chemistry 2015 Apr 10;290(15):9614-25

Periadventitial application of rapamycin-loaded nanoparticles produces sustained inhibition of vascular restenosis.

Shi X, Chen G, Guo LW, Si Y, Zhu M, Pilla S, Liu B, Gong S, Kent KC
PloS one 2014;9(2):e89227

Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage.

Herrnberger L, Hennig R, Kremer W, Hellerbrand C, Goepferich A, Kalbitzer HR, Tamm ER
PloS one 2014;9(12):e115005

ITE and TCDD differentially regulate the vascular remodeling of rat placenta via the activation of AhR.

Wu Y, Chen X, Zhou Q, He Q, Kang J, Zheng J, Wang K, Duan T
PloS one 2014;9(1):e86549

Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.

Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX
The American journal of pathology 2014 Oct;184(10):2709-20

Anticancer effects of gemcitabine are enhanced by co-administered iRGD peptide in murine pancreatic cancer models that overexpressed neuropilin-1.

Akashi Y, Oda T, Ohara Y, Miyamoto R, Kurokawa T, Hashimoto S, Enomoto T, Yamada K, Satake M, Ohkohchi N
British journal of cancer 2014 Mar 18;110(6):1481-7

MicroRNA-210 overexpression induces angiogenesis and neurogenesis in the normal adult mouse brain.

Zeng L, He X, Wang Y, Tang Y, Zheng C, Cai H, Liu J, Wang Y, Fu Y, Yang GY
Gene therapy 2014 Jan;21(1):37-43

Melanocyte-secreted fibromodulin promotes an angiogenic microenvironment.

Adini I, Ghosh K, Adini A, Chi ZL, Yoshimura T, Benny O, Connor KM, Rogers MS, Bazinet L, Birsner AE, Bielenberg DR, D'Amato RJ
The Journal of clinical investigation 2014 Jan;124(1):425-36

Characterization of the adverse effects of nicotine on placental development: in vivo and in vitro studies.

Holloway AC, Salomon A, Soares MJ, Garnier V, Raha S, Sergent F, Nicholson CJ, Feige JJ, Benharouga M, Alfaidy N
American journal of physiology. Endocrinology and metabolism 2014 Feb 15;306(4):E443-56

Endoglin regulates the activation and quiescence of endothelium by participating in canonical and non-canonical TGF-β signaling pathways.

Park S, Dimaio TA, Liu W, Wang S, Sorenson CM, Sheibani N
Journal of cell science 2013 Mar 15;126(Pt 6):1392-405

TGF-β mediates homing of bone marrow-derived human mesenchymal stem cells to glioma stem cells.

Shinojima N, Hossain A, Takezaki T, Fueyo J, Gumin J, Gao F, Nwajei F, Marini FC, Andreeff M, Kuratsu J, Lang FF
Cancer research 2013 Apr 1;73(7):2333-44

The critical role of agrin in the hematopoietic stem cell niche.

Mazzon C, Anselmo A, Cibella J, Soldani C, Destro A, Kim N, Roncalli M, Burden SJ, Dustin ML, Sarukhan A, Viola A
Blood 2011 Sep 8;118(10):2733-42

Dysfunctional microvasculature as a consequence of shb gene inactivation causes impaired tumor growth.

Funa NS, Kriz V, Zang G, Calounova G, Akerblom B, Mares J, Larsson E, Sun Y, Betsholtz C, Welsh M
Cancer research 2009 Mar 1;69(5):2141-8

Crosstalk between keratinocytes and adaptive immune cells in an IkappaBalpha protein-mediated inflammatory disease of the skin.

Rebholz B, Haase I, Eckelt B, Paxian S, Flaig MJ, Ghoreschi K, Nedospasov SA, Mailhammer R, Debey-Pascher S, Schultze JL, Weindl G, Förster I, Huss R, Stratis A, Ruzicka T, Röcken M, Pfeffer K, Schmid RM, Rupec RA
Immunity 2007 Aug;27(2):296-307

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Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Detection of Mouse CD31/PECAM-1 by Western Blot. Detection of Mouse CD31/PECAM-1 by Western Blot.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: CD31/PECAM-1 in Mouse Embryo. CD31/PECAM-1 in Mouse Embryo.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: CD31/PECAM-1 in Mouse Embryo. CD31/PECAM-1 in Mouse Embryo.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Detection of CD31/PECAM-1 in Rat Splenocytes by Flow Cytometry. Detection of CD31/PECAM-1 in Rat Splenocytes by Flow Cytometry.

Supportive validation

Submitted by: Novus Biologicals (provider)
Main image
Experimental details: Detection of CD31/PECAM-1 in Mouse Splenocytes by Flow Cytometry. Detection of CD31/PECAM-1 in Mouse Splenocytes by Flow Cytometry.