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APEX1
Apurinic/apyrimidinic endodeoxyribonuclease 1APE, APE-1, APEN, APEX, APX, HAP1, REF-1, REF1
The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases. [provided by RefSeq, Dec 2019]
Top validated antibodies |
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| Novus Biologicals |  NB100-116 |
94 references | Monoclonal |
WB
EL
ICC
IP
IHC
GS
PLA
ChIP
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| Invitrogen Antibodies | MA1-440 |
5 references | Monoclonal |
WB
ICC
IHC
FC
ChIP
OA
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| Proteintech Group | 10203-1-AP |
11 references | Polyclonal |
WB
EL
ICC
IP
IHC
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| GeneTex | GTX110558 |
Polyclonal |
WB
ICC
IP
IHC
ChIP
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| NSJ Bioreagents | V7287 |
Monoclonal |
WB
ICC
IHC
FC
PA
OA
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