Antibody data
- Antibody Data
- Antigen structure
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- Validations
- Western blot [1]
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- Product number
- BS8383 - Provider product page
- Provider
- Bioworld Technology, Inc
- Product name
- RGS7 polyclonal antibody
- Antibody type
- Polyclonal
- Antigen
- Recombinant full length Human RGS7.
- Description
- Heterotrimeric G proteins function to relay information from cell surface receptors to various intracellular effectors. G proteins comprise Ï«, ÉÇ and ÎÛ subunits, and following activation the Ï« subunit binds GTP and dissociates from the ÉÇÎÛ complex. A large group of proteins have been identified as GTPase-activating proteins (GAPs), including the RGS (regulator of G protein signaling) family, which serve to deactivate specific GÏ« isoforms by increasing the rate at which they convert GTP to GDP. A subfamily of RGS proteins expressed in the central nervous system contain, in addition to the highly conserved RGS domain, a characteristic GGL domain, or G protein ÎÛ subunit-like domain, which mediates binding to GÉÇ 5 subunits. This subfamily, which includes RGS6, RGS7, RGS9 and RGS11, associates with GÉÇ 5 to form active GAP complexes that are predominantly localized to the cytosol. RGS/ÉÇ5 complexes preferentially target GÏ«o subunit for hydrolysis and inhibit GÉÇ1ÎÛ2-mediated activation of phospholipase C.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100ul
- Concentration
- 1 mg/ml
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
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Supportive validation
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- Bioworld Technology, Inc (provider)
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- Experimental details
- WesternBlot (WB) analysis of RGS7 polyclonal antibody