BS8383

antibody from Bioworld Technology, Inc
Targeting: RGS7
Provider product page for BS8383
Western blot
Immunohistochemistry

Antibody data

Product number
BS8383 - Provider product page
Provider
Bioworld Technology, Inc
Product name
RGS7 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human RGS7.
Description
Heterotrimeric G proteins function to relay information from cell surface receptors to various intracellular effectors. G proteins comprise Ï«, ÉÇ and ÎÛ subunits, and following activation the Ï« subunit binds GTP and dissociates from the ÉÇÎÛ complex. A large group of proteins have been identified as GTPase-activating proteins (GAPs), including the RGS (regulator of G protein signaling) family, which serve to deactivate specific GÏ« isoforms by increasing the rate at which they convert GTP to GDP. A subfamily of RGS proteins expressed in the central nervous system contain, in addition to the highly conserved RGS domain, a characteristic GGL domain, or G protein ÎÛ subunit-like domain, which mediates binding to GÉÇ 5 subunits. This subfamily, which includes RGS6, RGS7, RGS9 and RGS11, associates with GÉÇ 5 to form active GAP complexes that are predominantly localized to the cytosol. RGS/ÉÇ5 complexes preferentially target GÏ«o subunit for hydrolysis and inhibit GÉÇ1ÎÛ2-mediated activation of phospholipase C.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
RGS7 protein structure - BS8383 shown in red.