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LearnNBP1-77080
antibody from Novus Biologicals
Targeting: NLRP3
AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, DFNA34, FCAS, FCU, MWS, NALP3, PYPAF1
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [23]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- NBP1-77080 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-77080, RRID:AB_11031962
- Product name
- Rabbit Polyclonal NLRP3/NALP3 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified.
- Reactivity
- Human, Mouse
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 mg
- Concentration
- 1 mg/ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references High-intensity interval training and moderate-intensity continuous training alleviate β-amyloid deposition by inhibiting NLRP3 inflammasome activation in APPswe/PS1dE9 mice.
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice.
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.
Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury.
Mechanistic insight into the activity of a sulfone compound dapsone on Propionibacterium (Newly Reclassified as Cutibacterium) Acnes-mediated cytokine production.
miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis.
TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice.
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke.
Actin polymerization plays a significant role in asbestos-induced inflammasome activation in mesothelial cells in vitro.
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.
Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma.
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma.
Intermittent fasting attenuates inflammasome activity in ischemic stroke.
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke.
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.
Liang F, Huang T, Li B, Zhao Y, Zhang X, Xu B
Neuroreport 2020 Mar 25;31(5):425-432
Neuroreport 2020 Mar 25;31(5):425-432
AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice.
Kim H, Seo JS, Lee SY, Ha KT, Choi BT, Shin YI, Ju Yun Y, Shin HK
Brain, behavior, and immunity 2020 Jul;87:765-776
Brain, behavior, and immunity 2020 Jul;87:765-776
Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis.
Toyohara T, Roudnicky F, Florido MHC, Nakano T, Yu H, Katsuki S, Lee M, Meissner T, Friesen M, Davidow LS, Ptaszek L, Abe T, Rubin LL, Pereira AC, Aikawa M, Cowan CA
Cell stem cell 2020 Jul 2;27(1):147-157.e7
Cell stem cell 2020 Jul 2;27(1):147-157.e7
Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections.
Verma V, Gupta S, Kumar P, Yadav S, Dhanda RS, Gaind R, Arora R, Frimodt-Møller N, Yadav M
Frontiers in microbiology 2019;10:2020
Frontiers in microbiology 2019;10:2020
Disturbance of mitochondrial dynamics and mitophagy in sepsis-induced acute kidney injury.
Liu JX, Yang C, Zhang WH, Su HY, Liu ZJ, Pan Q, Liu HF
Life sciences 2019 Oct 15;235:116828
Life sciences 2019 Oct 15;235:116828
Mechanistic insight into the activity of a sulfone compound dapsone on Propionibacterium (Newly Reclassified as Cutibacterium) Acnes-mediated cytokine production.
Geyfman M, Debabov D, Poloso N, Alvandi N
Experimental dermatology 2019 Feb;28(2):190-197
Experimental dermatology 2019 Feb;28(2):190-197
miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis.
Pan Z, Shan Q, Gu P, Wang XM, Tai LW, Sun M, Luo X, Sun L, Cheung CW
Journal of neuroinflammation 2018 Jan 31;15(1):29
Journal of neuroinflammation 2018 Jan 31;15(1):29
TDP-43 upregulation mediated by the NLRP3 inflammasome induces cognitive impairment in 2 2',4,4'-tetrabromodiphenyl ether (BDE-47)-treated mice.
Zhuang J, Wen X, Zhang YQ, Shan Q, Zhang ZF, Zheng GH, Fan SH, Li MQ, Wu DM, Hu B, Lu J, Zheng YL
Brain, behavior, and immunity 2017 Oct;65:99-110
Brain, behavior, and immunity 2017 Oct;65:99-110
Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke.
Lee HI, Lee SW, Kim NG, Park KJ, Choi BT, Shin YI, Shin HK
Journal of biophotonics 2017 Nov;10(11):1502-1513
Journal of biophotonics 2017 Nov;10(11):1502-1513
Actin polymerization plays a significant role in asbestos-induced inflammasome activation in mesothelial cells in vitro.
MacPherson M, Westbom C, Kogan H, Shukla A
Histochemistry and cell biology 2017 May;147(5):595-604
Histochemistry and cell biology 2017 May;147(5):595-604
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S
Toxicological sciences : an official journal of the Society of Toxicology 2017 Feb;155(2):432-443
Toxicological sciences : an official journal of the Society of Toxicology 2017 Feb;155(2):432-443
NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide.
Zhu W, Cao FS, Feng J, Chen HW, Wan JR, Lu Q, Wang J
Neuroscience 2017 Feb 20;343:77-84
Neuroscience 2017 Feb 20;343:77-84
Inflammasome Modulation by Chemotherapeutics in Malignant Mesothelioma.
Westbom C, Thompson JK, Leggett A, MacPherson M, Beuschel S, Pass H, Vacek P, Shukla A
PloS one 2015;10(12):e0145404
PloS one 2015;10(12):e0145404
HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma.
Chi W, Chen H, Li F, Zhu Y, Yin W, Zhuo Y
Journal of neuroinflammation 2015 Jul 30;12:137
Journal of neuroinflammation 2015 Jul 30;12:137
Intermittent fasting attenuates inflammasome activity in ischemic stroke.
Fann DY, Santro T, Manzanero S, Widiapradja A, Cheng YL, Lee SY, Chunduri P, Jo DG, Stranahan AM, Mattson MP, Arumugam TV
Experimental neurology 2014 Jul;257:114-9
Experimental neurology 2014 Jul;257:114-9
Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke.
Fann DY, Lee SY, Manzanero S, Tang SC, Gelderblom M, Chunduri P, Bernreuther C, Glatzel M, Cheng YL, Thundyil J, Widiapradja A, Lok KZ, Foo SL, Wang YC, Li YI, Drummond GR, Basta M, Magnus T, Jo DG, Mattson MP, Sobey CG, Arumugam TV
Cell death & disease 2013 Sep 5;4:e790
Cell death & disease 2013 Sep 5;4:e790
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3.
Kanneganti TD, Ozören N, Body-Malapel M, Amer A, Park JH, Franchi L, Whitfield J, Barchet W, Colonna M, Vandenabeele P, Bertin J, Coyle A, Grant EP, Akira S, Núñez G
Nature 2006 Mar 9;440(7081):233-6
Nature 2006 Mar 9;440(7081):233-6
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J
Immunity 2004 Mar;20(3):319-25
Immunity 2004 Mar;20(3):319-25
NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder.
Agostini L, Martinon F, Burns K, McDermott MF, Hawkins PN, Tschopp J
Immunity 2004 Mar;20(3):319-25
Immunity 2004 Mar;20(3):319-25
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.
Chamaillard M, Girardin SE, Viala J, Philpott DJ
Cellular microbiology 2003 Sep;5(9):581-92
Cellular microbiology 2003 Sep;5(9):581-92
Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation.
Chamaillard M, Girardin SE, Viala J, Philpott DJ
Cellular microbiology 2003 Sep;5(9):581-92
Cellular microbiology 2003 Sep;5(9):581-92
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.
O'Connor W Jr, Harton JA, Zhu X, Linhoff MW, Ting JP
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6329-33
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6329-33
Cutting edge: CIAS1/cryopyrin/PYPAF1/NALP3/CATERPILLER 1.1 is an inducible inflammatory mediator with NF-kappa B suppressive properties.
O'Connor W Jr, Harton JA, Zhu X, Linhoff MW, Ting JP
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6329-33
Journal of immunology (Baltimore, Md. : 1950) 2003 Dec 15;171(12):6329-33
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: NLRP3/NALP3 Antibody [NBP1-77080] - Analysis of NALP3 in K562 cell lysate with NALP3 antibody at 1 ug/mL (A) in the absence and (B) in the presence of blocking peptide.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP1-77080] - Analysis of NALP3 in mouse lung tissue using anti-NALP3 antibody. Image from verified customer review.
