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Chromatin ImmunoprecipitationAntibody data
- Antibody Data
- Antigen structure
- References [20]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- NBP1-85823 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#NBP1-85823, RRID:AB_11003542
- Product name
- Rabbit Polyclonal SOX11 Antibody
- Antibody type
- Polyclonal
- Description
- Immunogen affinity purified. Specificity of human SOX11 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins.
- Reactivity
- Human
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 0.1 ml
- Storage
- Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Submitted references Reproducibility of SOX-11 detection in decalcified bone marrow tissue in mantle cell lymphoma patients.
Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.
High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma.
The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.
Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma.
The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases.
In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior.
Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index.
The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation.
Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis.
Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.
SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies.
Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms.
Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma.
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.
The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.
Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma.
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Righi S, Pileri S, Agostinelli C, Bacci F, Spagnolo S, Sabattini E
Human pathology 2017 Jan;59:94-101
Human pathology 2017 Jan;59:94-101
Plasma cell and terminal B-cell differentiation in mantle cell lymphoma mainly occur in the SOX11-negative subtype.
Ribera-Cortada I, Martinez D, Amador V, Royo C, Navarro A, Beà S, Gine E, de Leval L, Serrano S, Wotherspoon A, Colomer D, Martinez A, Campo E
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2015 Nov;28(11):1435-47
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2015 Nov;28(11):1435-47
High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma.
Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, Kahl BS, Verma AK, Gascoyne RD, Kimby E, Sander B, Ye BH, Melnick AM, Parekh S
Oncogene 2015 Mar 5;34(10):1231-40
Oncogene 2015 Mar 5;34(10):1231-40
The clinical role of epithelial-mesenchymal transition and stem cell markers in advanced-stage ovarian serous carcinoma effusions.
Davidson B, Holth A, Hellesylt E, Tan TZ, Huang RY, Tropé C, Nesland JM, Thiery JP
Human pathology 2015 Jan;46(1):1-8
Human pathology 2015 Jan;46(1):1-8
Prognostic role of SOX11 in a population-based cohort of mantle cell lymphoma.
Nygren L, Baumgartner Wennerholm S, Klimkowska M, Christensson B, Kimby E, Sander B
Blood 2012 May 3;119(18):4215-23
Blood 2012 May 3;119(18):4215-23
The expression of SOX11, cyclin D1, cyclin D2, and cyclin D3 in B-cell lymphocytic proliferative diseases.
Cao X, Fan L, Fang C, Zhu DX, Dong HJ, Wang DM, Wang YH, Xu W, Li JY
Medical oncology (Northwood, London, England) 2012 Jun;29(2):1190-6
Medical oncology (Northwood, London, England) 2012 Jun;29(2):1190-6
In situ mantle cell lymphoma: clinical implications of an incidental finding with indolent clinical behavior.
Carvajal-Cuenca A, Sua LF, Silva NM, Pittaluga S, Royo C, Song JY, Sargent RL, Espinet B, Climent F, Jacobs SA, Delabie J, Naresh KN, Bagg A, Brousset P, Warnke RA, Serrano S, Harris NL, Swerdlow SH, Jaffe ES, Campo E
Haematologica 2012 Feb;97(2):270-8
Haematologica 2012 Feb;97(2):270-8
Small cell variant of mantle cell lymphoma is an indolent lymphoma characterized by bone marrow involvement, splenomegaly, and a low Ki-67 index.
Kimura Y, Sato K, Imamura Y, Arakawa F, Kiyasu J, Takeuchi M, Miyoshi H, Yoshida M, Niino D, Sugita Y, Morito T, Yoshino T, Nakamura S, Ohshima K
Cancer science 2011 Sep;102(9):1734-41
Cancer science 2011 Sep;102(9):1734-41
The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation.
Sernbo S, Gustavsson E, Brennan DJ, Gallagher WM, Rexhepaj E, Rydnert F, Jirström K, Borrebaeck CA, Ek S
BMC cancer 2011 Sep 24;11:405
BMC cancer 2011 Sep 24;11:405
Indolent mantle cell leukemia: a clinicopathological variant characterized by isolated lymphocytosis, interstitial bone marrow involvement, kappa light chain restriction, and good prognosis.
Ondrejka SL, Lai R, Smith SD, Hsi ED
Haematologica 2011 Aug;96(8):1121-7
Haematologica 2011 Aug;96(8):1121-7
Gene expression profiling and chromatin immunoprecipitation identify DBN1, SETMAR and HIG2 as direct targets of SOX11 in mantle cell lymphoma.
Wang X, Björklund S, Wasik AM, Grandien A, Andersson P, Kimby E, Dahlman-Wright K, Zhao C, Christensson B, Sander B
PloS one 2010 Nov 22;5(11):e14085
PloS one 2010 Nov 22;5(11):e14085
Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network.
Aiden AP, Rivera MN, Rheinbay E, Ku M, Coffman EJ, Truong TT, Vargas SO, Lander ES, Haber DA, Bernstein BE
Cell stem cell 2010 Jun 4;6(6):591-602
Cell stem cell 2010 Jun 4;6(6):591-602
SOX11 expression correlates to promoter methylation and regulates tumor growth in hematopoietic malignancies.
Gustavsson E, Sernbo S, Andersson E, Brennan DJ, Dictor M, Jerkeman M, Borrebaeck CA, Ek S
Molecular cancer 2010 Jul 12;9:187
Molecular cancer 2010 Jul 12;9:187
Nuclear expression of sox11 is highly associated with mantle cell lymphoma but is independent of t(11;14)(q13;q32) in non-mantle cell B-cell neoplasms.
Chen YH, Gao J, Fan G, Peterson LC
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 Jan;23(1):105-12
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2010 Jan;23(1):105-12
Genomic and gene expression profiling defines indolent forms of mantle cell lymphoma.
Fernàndez V, Salamero O, Espinet B, Solé F, Royo C, Navarro A, Camacho F, Beà S, Hartmann E, Amador V, Hernández L, Agostinelli C, Sargent RL, Rozman M, Aymerich M, Colomer D, Villamor N, Swerdlow SH, Pileri SA, Bosch F, Piris MA, Montserrat E, Ott G, Rosenwald A, López-Guillermo A, Jares P, Serrano S, Campo E
Cancer research 2010 Feb 15;70(4):1408-18
Cancer research 2010 Feb 15;70(4):1408-18
Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.
Dictor M, Ek S, Sundberg M, Warenholt J, György C, Sernbo S, Gustavsson E, Abu-Alsoud W, Wadström T, Borrebaeck C
Haematologica 2009 Nov;94(11):1563-8
Haematologica 2009 Nov;94(11):1563-8
SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype.
Mozos A, Royo C, Hartmann E, De Jong D, Baró C, Valera A, Fu K, Weisenburger DD, Delabie J, Chuang SS, Jaffe ES, Ruiz-Marcellan C, Dave S, Rimsza L, Braziel R, Gascoyne RD, Solé F, López-Guillermo A, Colomer D, Staudt LM, Rosenwald A, Ott G, Jares P, Campo E
Haematologica 2009 Nov;94(11):1555-62
Haematologica 2009 Nov;94(11):1555-62
The subcellular Sox11 distribution pattern identifies subsets of mantle cell lymphoma: correlation to overall survival.
Wang X, Asplund AC, Porwit A, Flygare J, Smith CI, Christensson B, Sander B
British journal of haematology 2008 Oct;143(2):248-52
British journal of haematology 2008 Oct;143(2):248-52
Nuclear expression of the non B-cell lineage Sox11 transcription factor identifies mantle cell lymphoma.
Ek S, Dictor M, Jerkeman M, Jirström K, Borrebaeck CA
Blood 2008 Jan 15;111(2):800-5
Blood 2008 Jan 15;111(2):800-5
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Ek S, Andréasson U, Hober S, Kampf C, Pontén F, Uhlén M, Merz H, Borrebaeck CA
Molecular & cellular proteomics : MCP 2006 Jun;5(6):1072-81
Molecular & cellular proteomics : MCP 2006 Jun;5(6):1072-81
No comments: Submit comment
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: SOX11 Antibody [NBP1-85823] - Analysis in human cell line SH-SY5Y.
Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SOX11 Antibody [NBP1-85823] - Staining of human chronic lymphocytic leukemia shows no nuclear positivity in tumor cells as expected.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Immunohistochemistry-Paraffin: SOX11 Antibody [NBP1-85823] - Staining of human mantle cell lymphoma shows moderate to strong nuclear positivity in tumor cells.
