ULK4

This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]

Description

Unc-51 like kinase 4

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Mitochondria, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

3 (41246599 - 41962130)

Ensembl ID

ENSG00000168038  (ver. 103.38)

Orthologs

Mouse Ulk4: ENSMUSG00000040936

UniProt

Q96C45

neXtProt

NX_Q96C45

Human splice variants
Mouse splice variants

Protein structure