CXCL17

The protein encoded by this gene is a mucosal chemokine that attracts immature dendritic cells and blood monocytes to the lungs. The encoded protein also promotes tumorigenesis through an angiogenic activity. Finally, this protein exhibits strong antimicrobial activity against E. coli, S. aureus, Salmonella, P. aeruginosa, and C. albicans. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]

Description

C-X-C motif chemokine ligand 17

Tissue specificity

Group enriched (esophagus, lung, salivary gland, stomach)

Predicted location

Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (42428278 - 42442946)

Ensembl ID

ENSG00000189377  (ver. 103.38)

Orthologs

Mouse Cxcl17: ENSMUSG00000060188

UniProt

Q6UXB2

neXtProt

NX_Q6UXB2

Human splice variants
Mouse splice variants

Protein structure