ACSM2A

This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event. [provided by RefSeq, May 2017]

Description

Acyl-CoA synthetase medium chain family member 2A

Tissue specificity

Group enriched (kidney, liver)

Predicted location

Intracellular, Membrane

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

16 (20451461 - 20487669)

Ensembl ID

ENSG00000183747  (ver. 103.38)

Orthologs

-

UniProt

Q08AH3

neXtProt

NX_Q08AH3

Human splice variants

Protein structure