BS8687

antibody from Bioworld Technology, Inc
Targeting: SUB1 p14, p15, PC4
Provider product page for BS8687
Western blot
Immunocytochemistry
Immunohistochemistry

Antibody data

Product number
BS8687 - Provider product page
Provider
Bioworld Technology, Inc
Product name
SUB1 polyclonal antibody
Antibody type
Polyclonal
Antigen
Activated RNA polymerase II transcriptional coactivator p15; Positive cofactor 4; PC4; SUB1 homolog; p14; SUB1; PC4, RPO2TC1
Description
RNA polymerase II (RNAPII) holoenzyme contains numerous proteins that largely consist of RNA processing factors, RNA helicase, general transcription factors and SRB co-activating complexes. RNAPII mediated basal- and gene-specific transcriptional activation requires the association of various cofactors that includes PC4 (human Positive cofactor 4). Positive cofactor 4 interacts with the activation domain of transcription factor IIA (TFIIA) and TATA-binding protein (TBP)-associated factors (TAFs) to directly bind to double stranded DNA. Positive cofactor 4 induces both activation and repression of RNAPII basal transcription, depending on the presence or absence of these transcription factors and holoenzyme components. Addition-ally, Positive cofactor 4 is phosphorylated by TFIID and TFIIH, which releases Positive cofactor 4 from the DNA promoter region and thereby inhibits the assembly of Positive cofactor 4 into the transcriptional promoting complex and blocks transcription.
Reactivity
Human, Mouse
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
SUB1 protein structure - BS8687 shown in red.