FGR

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to plasma membrane ruffles, and functions as a negative regulator of cell migration and adhesion triggered by the beta-2 integrin signal transduction pathway. Infection with Epstein-Barr virus results in the overexpression of this gene. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

Description

FGR proto-oncogene, Src family tyrosine kinase

Tissue specificity

Group enriched (bone marrow, lung, lymphoid tissue)

Subcell location

Plasma membrane, Aggresome

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (27612064 - 27635185)

Ensembl ID

ENSG00000000938  (ver. 103.38)

Orthologs

Mouse Fgr: ENSMUSG00000028874

UniProt

P09769

neXtProt

NX_P09769

Human splice variants
Mouse splice variants

Protein structure