PTPN6

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Description

Protein tyrosine phosphatase non-receptor type 6

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Nucleoplasm, Nucleoli

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (6946468 - 6961316)

Ensembl ID

ENSG00000111679  (ver. 103.38)

Orthologs

Mouse Ptpn6: ENSMUSG00000004266

UniProt

P29350

neXtProt

NX_P29350

Human splice variants
Mouse splice variants

Protein structure