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Cell line expression
Protein structure
RBBP8
RB binding protein 8, endonucleaseCOM1, CtIP, RIM, SCKL2
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| GeneTex |  GTX70264 |
6 references | Monoclonal |
WB
ICC
IP
PLA
ChIP
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| Novus Biologicals | NBP1-41205 |
3 references | Monoclonal |
WB
ICC
IP
PLA
ChIP
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| Boster Biological Technology | A02076-1 |
Polyclonal |
WB
EL
ICC
IHC
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| Proteintech Group | 12624-1-AP |
2 references | Polyclonal |
WB
EL
|
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| antibodies-online | ABIN256682 |
4 references | Polyclonal |
WB
ICC
IP
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