SYK

This gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

Description

Spleen associated tyrosine kinase

Tissue specificity

Tissue enhanced (lymphoid tissue, parathyroid gland)

Subcell location

Vesicles, Plasma membrane, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (90801787 - 90898549)

Ensembl ID

ENSG00000165025  (ver. 103.38)

Orthologs

Mouse Syk: ENSMUSG00000021457

UniProt

P43405

neXtProt

NX_P43405

Human splice variants
Mouse splice variants

Protein structure