LCK

This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]

Description

LCK proto-oncogene, Src family tyrosine kinase

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Golgi apparatus

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (32251239 - 32286165)

Ensembl ID

ENSG00000182866  (ver. 103.38)

Orthologs

Mouse Lck: ENSMUSG00000000409

UniProt

P06239

neXtProt

NX_P06239

Human splice variants
Mouse splice variants

Protein structure