SON

This gene encodes a protein that contains multiple simple repeats. The encoded protein binds RNA and promotes pre-mRNA splicing, particularly of transcripts with poor splice sites. The protein also recognizes a specific DNA sequence found in the human hepatitis B virus (HBV) and represses HBV core promoter activity. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Description

SON DNA and RNA binding protein

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Transporters

Chromosome

21 (33543038 - 33577481)

Ensembl ID

ENSG00000159140  (ver. 103.38)

Orthologs

Mouse Son: ENSMUSG00000022961

UniProt

P18583

neXtProt

NX_P18583

Human splice variants
Mouse splice variants

Protein structure