PRB4

This gene encodes a member of the heterogeneous family of basic, proline-rich, human salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature peptides before secretion from the parotid glands. Multiple alleles of this gene exhibiting variations in the length of the tandem repeats have been identified. The reference genome encodes the ""Small"" allele. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Nov 2015]

Description

Proline rich protein BstNI subfamily 4

Tissue specificity

Tissue enriched (salivary gland)

Predicted location

Secreted to digestive system

Protein family

Predicted secreted proteins

Chromosome

12 (11307077 - 11310436)

Ensembl ID

ENSG00000230657  (ver. 103.38)

Orthologs

-

UniProt

 

neXtProt

 

Human splice variants

Protein structure