SLC46A3

The protein encoded by this gene is a member of a transmembrane protein family that transports small molecules across membranes. The encoded protein has been found in lysosomal membranes, where it can transport catabolites from the lysosomes to the cytoplasm. This protein has been shown to be an effective transporter of the cytotoxic drug maytansine, which is used in antibody-based targeting of cancer cells. [provided by RefSeq, Dec 2016]

Description

Solute carrier family 46 member 3

Tissue specificity

Tissue enhanced (intestine, liver)

Subcell location

Plasma membrane, Actin filaments, Cytosol

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

13 (28700064 - 28718970)

Ensembl ID

ENSG00000139508  (ver. 103.38)

Orthologs

Mouse Slc46a3: ENSMUSG00000029650

UniProt

Q7Z3Q1

neXtProt

NX_Q7Z3Q1

Human splice variants
Mouse splice variants

Protein structure