GPIHBP1

This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Description

Glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1

Tissue specificity

Tissue enhanced (adipose tissue, brain, breast)

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins

Chromosome

8 (143213218 - 143217170)

Ensembl ID

ENSG00000277494  (ver. 103.38)

Orthologs

Mouse Gpihbp1: ENSMUSG00000022579

UniProt

Q8IV16

neXtProt

NX_Q8IV16

Human splice variants
Mouse splice variants

Protein structure