M00300
antibody from Boster Biological Technology
Targeting: SQSTM1
A170, OSIL, p60, p62, p62B, PDB3
Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations [0]
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- Product number
- M00300 - Provider product page
- Provider
- Boster Biological Technology
- Product name
- Anti-p62/SQSTM1 Rabbit Monoclonal Antibody
- Antibody type
- Monoclonal
- Description
- Monoclonal antibody for p62/SQSTM1 detection. Host: Rabbit.Size: 100ug/vial. Tested applications: Flow Cytometry, IF, ICC, WB. Reactive species: Human, Mouse, Rat p62/SQSTM1 information: Molecular Weight: 47687 MW; Subcellular Localization: Cytoplasm. Late endosome. Lysosome. Cytoplasmic vesicle, autophagosome. Nucleus. Endoplasmic reticulum. Cytoplasm, P-body. Sarcomere (By similarity). In cardiac muscles localizes to the sarcomeric band (By similarity). Commonly found in inclusion bodies containing polyubiquitinated protein aggregates. In neurodegenerative diseases, detected in Lewy bodies in Parkinson disease, neurofibrillary tangles in Alzheimer disease, and HTT aggregates in Huntington disease. In protein aggregate diseases of the liver, found in large amounts in Mallory bodies of alcoholic and nonalcoholic steatohepatitis, hyaline bodies in hepatocellular carcinoma, and in SERPINA1 aggregates. Enriched in Rosenthal fibers of pilocytic astrocytoma. In the cytoplasm, observed in both membrane-free ubiquitin- containing protein aggregates (sequestosomes) and membrane- surrounded autophagosomes. Colocalizes with TRIM13 in the perinuclear endop
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Antibody clone number
- EBB-19
- Vial size
- 100ug/vial
- Concentration
- 0.5-1mg/ml, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.
- Storage
- At -20°C for one year. Avoid repeated freezing and thawing.
Submitted references Cantharidin-induced toxic injury, oxidative stress, and autophagy attenuated by Astragalus polysaccharides in mouse testis.
Study on the neuroprotective effect of Zhimu-Huangbo extract on mitochondrial dysfunction in HT22 cells induced by D-galactose by promoting mitochondrial autophagy.
Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis.
Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy.
Prevention of UVB Induced Metabolic Changes in Epidermal Cells by Lipid Extract from Microalgae Nannochloropsis oceanica.
Regulation of the autophagy plays an important role in acute kidney injury induced acute lung injury.
Integrated metabolomics and mechanism to reveal the protective effect of kaempferol on pulmonary arterial hypertension.
Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy.
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Xiao Y, Liu R, Tang W, Yang C
Reproductive toxicology (Elmsford, N.Y.) 2024 Jan;123:108520
Reproductive toxicology (Elmsford, N.Y.) 2024 Jan;123:108520
Study on the neuroprotective effect of Zhimu-Huangbo extract on mitochondrial dysfunction in HT22 cells induced by D-galactose by promoting mitochondrial autophagy.
Xue A, Zhao D, Zhao C, Li X, Yang M, Zhao H, Zhao C, Lei X, Wu J, Zhang N
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117012
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117012
Lower dose of metformin combined with artesunate induced autophagy-dependent apoptosis of glioblastoma by activating ROS-AMPK-mTOR axis.
Ding W, Liao L, Liu J, Zhao J, Tang Q, Liao Y
Experimental cell research 2023 Sep 1;430(1):113691
Experimental cell research 2023 Sep 1;430(1):113691
Strontium Ranelate Inhibits Osteoclastogenesis through NF-κB-Pathway-Dependent Autophagy.
Wu D, Sun X, Zhao Y, Liu Y, Gan Z, Zhang Z, Chen X, Cao Y
Bioengineering (Basel, Switzerland) 2023 Mar 16;10(3)
Bioengineering (Basel, Switzerland) 2023 Mar 16;10(3)
Prevention of UVB Induced Metabolic Changes in Epidermal Cells by Lipid Extract from Microalgae Nannochloropsis oceanica.
Stasiewicz A, Conde T, Gęgotek A, Domingues MR, Domingues P, Skrzydlewska E
International journal of molecular sciences 2023 Jul 11;24(14)
International journal of molecular sciences 2023 Jul 11;24(14)
Regulation of the autophagy plays an important role in acute kidney injury induced acute lung injury.
Wang R, Shen S, Jian L, Liu S, Yuan Q, Guo H, Huang J, Chen P, Huang R
Renal failure 2022 Dec;44(1):1754-1768
Renal failure 2022 Dec;44(1):1754-1768
Integrated metabolomics and mechanism to reveal the protective effect of kaempferol on pulmonary arterial hypertension.
Yi J, Wang X, Song K, Ren J, Che H, Yu H, Li Q
Journal of pharmaceutical and biomedical analysis 2022 Apr 1;212:114662
Journal of pharmaceutical and biomedical analysis 2022 Apr 1;212:114662
Transient Receptor Potential Melastatin 8 (TRPM8) Channel Regulates Proliferation and Migration of Breast Cancer Cells by Activating the AMPK-ULK1 Pathway to Enhance Basal Autophagy.
Huang Y, Li S, Jia Z, Zhao W, Zhou C, Zhang R, Ali DW, Michalak M, Chen XZ, Tang J
Frontiers in oncology 2020;10:573127
Frontiers in oncology 2020;10:573127
Integral membrane protein 2A inhibits cell growth in human breast cancer via enhancing autophagy induction.
Zhou C, Wang M, Yang J, Xiong H, Wang Y, Tang J
Cell communication and signaling : CCS 2019 Aug 22;17(1):105
Cell communication and signaling : CCS 2019 Aug 22;17(1):105
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